Fertility After Uterine Artery Embolization: Investigation Using a Sheep Model

Abstract

Uterine artery embolization influenced reproductive ability in sheep and UAE with GP could lead to intrauterine growth retardation.

Reproductive Ability After Uterine Artery Embolization in a Sheep Model: Observation Over 2 Seasons

“…Considering results of the current study, together with those of previous experimental animal studies, 10,11 it can be concluded that UAE might cause a decrease in fertility with transient hypotrophy of the newborn; however, UAE would not have a critical impact on reproductive ability in the long term. Nevertheless, in women desiring future fertility, it is important to be aware of the possible relationship between complications associated with UAE and pregnancy.…”

“…There was a statistically significant decrease in the fertility rate and gestation rate in the PVA group versus controls but not in the TAGM group versus controls. In addition, in a more recent report 11 in which GP and TAGM were used as embolic agents instead of PVA and TAGM, as in the study of Laurent et al, 10 lambs born from ewes that had been embolized with GP were smaller than those born from controls and from ewes embolized with TAGM.…”

“…These results of previous studies suggest that UAE with some embolic agents such as PVA and GP might influence intrauterine growth. 10,11 Indeed, it might be highly suspected that usage of some embolic agents can influence intrauterine growth; however, the mid-term effect of UAE on fertility has not been clarified. Generally, the reproductive cycle of sheep is the delivery of 1 lamb each year.…”

“…[2][3][4] In animal experimentations using a sheep model, there was a tendency for lambs delivered from ewes that had undergone UAE with embolic agents to be small just after birth in comparison with control animals. 10,11 However, previous animal experiments have not investigated the mid-or longterm effect of UAE on fertility.…”

Conservative Management of Cervical Pregnancy with the Administration of Methotrexate and Potassium Chloride: A Case Report

“…However, there are scientific limitations due to the rarity of cases; the trend of modern clinical practice is more Case Reports in Obstetrics and Gynecology towards conservative nonoperative management [12,17]. Management of pregnancy depends on several factors including gestational age, fetal heart activity, patient stability, interest in maintaining fertility, and availability of medical and specialized facilities.…”