Fertilising ability of testicular spermatozoa

Craft, Ian; Bennett, Valerie; Nicholson, Natasha

doi:10.1016/0140-6736(93)92722-6

Cited by 180 publications

(81 citation statements)

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“…Therefore, clinicians and scientists providing ICSI for infertile men must be aware of the genetic implications of male factor infertility. ICSI using surgically retrieved spermatozoa has achieved good fertilization and pregnancy rates that are comparable to those for ICSI with ejaculated spermatozoa (Craft et al, 1993;FIVNAT, 1993;Silber et al, 1994;Tournaye et al, 1994;Hovatta et al, 1995;Fahmy et al, 1996;Tarlatzis, 1996;Mansour et al, 1997a). Different researchers have studied fertilization and pregnancy rates after ICSI using epididymal versus testicular spermatozoa (Hovatta et al, 1995;Nagy et al, 1995b;Silber et al, 1995a;Mansour et al, 1997a;Tarlatzis, 1996).…”

Section: Potential Risks Of Icsimentioning

confidence: 99%

“…Until recently, the fertilizing capacity of testicular spermatozoa was unexplored. However, it was reported in 1993 that the use of testicular spermatozoa in ICSI for cases of obstructive azoospermia could achieve fertilization and pregnancy (Craft et al, 1993;Schoysman et al, 1993a,b). Following that, other different programmes reported the use of testicular spermatozoa with ICSI Bourne et al, 1995b;Nagy et al, 1995b;Silber et al, 1995a;Fahmy et al, 1996;Mansour et al, 1996a).…”

Section: Clinical Application Of Icsimentioning

confidence: 99%

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Intracytoplasmic sperm injection: a state of the art technique

Mansour

1998

Human Reproduction Update

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Section: Potential Risks Of Icsimentioning

confidence: 99%

Section: Clinical Application Of Icsimentioning

confidence: 99%

Intracytoplasmic sperm injection: a state of the art technique

Mansour

1998

Human Reproduction Update

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“…The only requirement for ICSI is to provide a living spermatozoon. In recent years, ICSI has been extended to azoospermic men by using spermatozoa extracted from the epididymis or the testis of patients with obstructive (OA) (Craft et al, 1993;Schoysman et al, 1993) or nonobstructive (NOA) azoospermia, respectively (Tournaye et al, 1995). Therefore, these patients, who were previously considered sterile, can today father their own child undergoing ICSI with the few spermatozoa retrieved from the epididymis or the testis.…”

confidence: 99%

Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype

Burrello¹,

Vicari²,

Calogero³

2005

Cytogenet Genome Res

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Since epididymal and testicular spermatozoa of azoospermic patients are frequently used for intracytoplasmic sperm injection (ICSI), many studies have been carried out to evaluate their karyotype. This article will review all published data on this topic. In most of the studies, spermatozoa have been retrieved from the testis or the epididymis of patients with nonobstructive (NOA) or obstructive (OA) azoospermia, respectively. Sperm aneuploidy has been evaluated by fluorescence in situ hybridization using probes for sex chromosomes and an array of autosomes. A significantly higher sperm aneuploidy rate has been reported in patients with NOA and OA compared to ejaculated spermatozoa, mainly for sex chromosomes. The magnitude of the increase varies between studies, probably because of the heterogeneity of case selection as well as of the methodology employed. The majority of the studies reported that patients with NOA have a greater sperm aneuploidy rate compared to OA. The greater frequency of sperm aneuploidy in azoospermic patients increases the risk of transmitting a karyotype abnormality to the offspring generated by ICSI.

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“…On another occassion, Dr. Tucker attempted to publish the term Sperm Head Injection Technique (i.e., SHIT) which aroused a good laugh by the editor of Human Reproduction, Dr. Bob Edwards, but it never made it into press [102]. "ICSI" it was, as still other early clinical efforts independently proved their injection procedures were efficacious for severe male factor sperm [103,104], and that alternative microinjection approaches and microtool-manufacturing equipment could be effectively used [101,105].…”

Section: Intracytoplasmic Sperm Injectionmentioning

confidence: 99%

The Historic Development and Incorporation of Four Assisted Reproductive Technologies Shaping Today′s IVF Industry

Schiewe¹

2016

JFIV Reprod Med Genet

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The concept of assisted reproductive technologies was most notably derived from the late 19th Century experiments of Sir Walter Heape who successfully transplanted rabbit embryos. Interestingly, it was not until the late 1940's and 1950's that renewed interests in rabbit embryo transfer and cryobiology occurred. The history behind developing effective procedures can be fascinating, though few could be more accidental than Dr. Chris Polge's discovery of glycerol (1948), from a mislabeled bottle of sugar solutions, being an effective cryoprotective agent for sperm freezing. The purpose of this review paper is to discuss four key scientific breakthrough technologies occurring between 1985 and 1995, which ultimately shaped the future of today's human in vitro fertilization (IVF) industry. More importantly, this paper highlights the foundation of underlying related discoveries and some unique stories involving their development and publication. In the end, this paper emphasizes the value of understanding scientific discovery timetables and the eventual re-discovery in the hands and minds of creative, determined and dedicated scientists, as history tends to repeat itself before its useful application is realized.

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Fertilising ability of testicular spermatozoa

Cited by 180 publications

References 1 publication

Intracytoplasmic sperm injection: a state of the art technique

Intracytoplasmic sperm injection: a state of the art technique

Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype

The Historic Development and Incorporation of Four Assisted Reproductive Technologies Shaping Today′s IVF Industry

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