Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Zuo, Ying-Bing; Zhang, Yinfeng; Zhang, Rui; Tian, Jiawei; Lv, Xiaobing; Li, Rong; Li, Shuping; Cheng, Meng-Die; Shan, Jing; Zhao, Zheng; Hui, Xin

doi:10.7150/ijbs.66917

Cited by 60 publications

(45 citation statements)

References 146 publications

(168 reference statements)

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“…35 Genetic variations of PRKAA1 associate with prognosis for patients with colorectal cancer [45]. Recently, studies have revealed that some noncoding RNAs (ncRNAs), particularly microRNAs, long noncoding RNAs, and circular RNAs, were involved in the regulation of ferroptosis and affect cancer growth [46]. Moreover, Katsaraki et al proposed that ncRNA plays an important role in CLL and summarizes the important discovery about their value as regulators, biomarkers, or therapeutic targets in B-CLL [47].…”

Section: Discussionmentioning

confidence: 99%

A Ferroptosis Molecular Subtype-Related Signature for Predicting Prognosis and Response to Chemotherapy in Patients with Chronic Lymphocytic Leukemia

Gong

Qin

et al. 2022

BioMed Research International

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Ferroptosis is a type of regulated cell death catalyzed by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Chronic lymphocytic leukemia (CLL) is a chronic lymphoproliferative disorder. However, the understanding of ferroptosis in CLL remains largely poor. In this study, we investigated the stratification and prognostic role of ferroptosis-related genes in CLL patients of ICGC cohort. We obtained fourteen genes with prognostic value by screening 110 ferroptosis-related genes (FRGs). Based on the expression profiles of these 14 genes, we classified CLL patients into two clusters. Most of the FRGs were highly expressed in cluster 1, and cluster 1 was associated with better overall survival (OS). Subsequently, we developed an eight-gene signature (TP63, STEAP3, NQO1, ELAVL1, PRKAA1, HELLS, FANCD2, and CDKN2A) by using LASSO analysis. This risk signature divided CLL patients into high- and low-risk groups. We used Cox regression analysis and ROC analysis demonstrated the risk signature was reliable and robust. And we validated the risk model in an external cohort (GSE22762). We also conducted enrichment analysis and genomic mutation analysis. Finally, we explored the potential effect of chemotherapy between the two risk groups. Our study contributed to understanding the role of ferroptosis in CLL and facilitated personalized and precision treatment.

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Section: Discussionmentioning

confidence: 99%

A Ferroptosis Molecular Subtype-Related Signature for Predicting Prognosis and Response to Chemotherapy in Patients with Chronic Lymphocytic Leukemia

Gong

Qin

et al. 2022

BioMed Research International

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Section: Biogenesis and Function Of Lncrnas And Lncrnas-mediated Prog...mentioning

confidence: 99%

“…Ferroptosis, an iron-dependent programmed cell death, can affect the prognosis of several tumors. A number of lncRNAs can alter the outcome of tumors by modulating the process of ferroptosis (237).In a study of Li et al (238), the OSCC prognostic model was established on the basis of 8 frlncRNAs which have a prognostic role and expressed simultaneously with 25 mRNAs. Their study supported a prognostic model in patients with OSCC comprised of 8 different frlncRNAs, including MIAT,AC099850.3, STARD4-AS1, AC090246.1, AC021087.4, HOTARM1,ALMS1-IT1and AL512274.1., which can be used as a prognostic indicator and immune evaluation in OSCC patients and can be subsequently be used as promising therapeutic targets in these patients (238).…”

Section: Inhibition Of Apoptosismentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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“…Ferroptosis has become a hot research topic in tumor; the pathway network between iron metabolism, Fenton reaction, Xc-system, and GPX4 has been initially established ( 183 , 184 ); and other important related pathways (including transsulfur pathway) and ferroptosis-related drugs need to be further investigated. Current chemotherapy regimens for OC are still dominated by platinum and paclitaxel drugs, but the prognosis of patients with advanced OC remains bleak.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Zhang

Liu

2022

Front. Immunol.

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Ovarian cancer (OC) is one of the most common malignancies that causes death in women and is a heterogeneous disease with complex molecular and genetic changes. Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring via a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.

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Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Cited by 60 publications

References 146 publications

A Ferroptosis Molecular Subtype-Related Signature for Predicting Prognosis and Response to Chemotherapy in Patients with Chronic Lymphocytic Leukemia

A Ferroptosis Molecular Subtype-Related Signature for Predicting Prognosis and Response to Chemotherapy in Patients with Chronic Lymphocytic Leukemia

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

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