Ferroptosis: a new strategy for Chinese herbal medicine treatment of diabetic nephropathy

Wei, Miaomiao; Liu, Xingxing; Tan, Zhao-Ming; Tian, Xiaofeng; Li, Mingdi; Wei, Junping

doi:10.3389/fendo.2023.1188003

Cited by 4 publications

(2 citation statements)

References 249 publications

(112 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 89 Mounting studies suggest that ferroptosis plays an important role in kidney cells injury and is one of the key mechanisms to induce DN, supporting that ferroptosis could be a potential therapeutic target for DN. 90 , 91 The marker of ferroptosis, GPX4, is decreased in db/db mice and T2D patients, which means ferroptosis plays a pathophysiologic role in DN, 68 which means ferroptosis might serve as a target for treating DN. In this section, we mainly separately discuss the role of ferroptosis in podocytes, GECs, GMCs and TECs.…”

Section: Ferroptosis and Dnmentioning

confidence: 99%

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

Li,

Gao,

et al. 2024

DMSO

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes and can potentially develop into end-stage renal disease. Its pathogenesis is complex and not fully understood. Podocytes, glomerular endothelial cells (GECs), glomerular mesangial cells (GMCs) and renal tubular epithelial cells (TECs) play important roles in the normal function of glomerulus and renal tubules, and their injury is involved in the progression of DN. Although our understanding of the mechanisms leading to DN has substantially improved, we still need to find more effective therapeutic targets. Autophagy, pyroptosis and ferroptosis are programmed cell death processes that are associated with inflammation and are closely related to a variety of diseases. Recently, a growing number of studies have reported that autophagy, pyroptosis and ferroptosis regulate the function of podocytes, GECs, GMCs and TECs. This review highlights the contributions of autophagy, pyroptosis, and ferroptosis to DN injury in these cells, offering potential therapeutic targets for DN treatment.

show abstract

Section: Ferroptosis and Dnmentioning

confidence: 99%

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

Li,

Gao,

et al. 2024

DMSO

View full text Add to dashboard Cite

show abstract

“…Over the past few decades, the way people with diabetic nephropathy are treated has changed dramatically (Sawaf et al, 2022), with many patients with refractory disease benefitting from new treatments but a large proportion of patients still progress to advanced disease stages. The pathogenesis of diabetic nephropathy is complex, involving oxidative stress, an inflammatory response, autophagy, programmed cell death and other mechanisms (Duan et al, 2021;Wan et al, 2022;Han et al, 2023;Wei et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Identification and validation of disulfidptosis-related gene signatures and their subtype in diabetic nephropathy

Xu,

Jiang,

Xiao

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

Background: Diabetic nephropathy (DN) is the most common complication of diabetes, and its pathogenesis is complex involving a variety of programmed cell death, inflammatory responses, and autophagy mechanisms. Disulfidptosis is a newly discovered mechanism of cell death. There are little studies about the role of disulfidptosis on DN.Methods: First, we obtained the data required for this study from the GeneCards database, the Nephroseq v5 database, and the GEO database. Through differential analysis, we obtained differential disulfidptosis-related genes. At the same time, through WGCNA analysis, we obtained key module genes in DN patients. The obtained intersecting genes were further screened by Lasso as well as SVM-RFE. By intersecting the results of the two, we ended up with a key gene for diabetic nephropathy. The diagnostic performance and expression of key genes were verified by the GSE30528, GSE30529, GSE96804, and Nephroseq v5 datasets. Using clinical information from the Nephroseq v5 database, we investigated the correlation between the expression of key genes and estimated glomerular filtration rate (eGFR) and serum creatinine content. Next, we constructed a nomogram and analyzed the immune microenvironment of patients with DN. The identification of subtypes facilitates individualized treatment of patients with DN.Results: We obtained 91 differential disulfidptosis-related genes. Through WGCNA analysis, we obtained 39 key module genes in DN patients. Taking the intersection of the two, we preliminarily screened 20 genes characteristic of DN. Through correlation analysis, we found that these 20 genes are positively correlated with each other. Further screening by Lasso and SVM-RFE algorithms and intersecting the results of the two, we identified CXCL6, CD48, C1QB, and COL6A3 as key genes in DN. Clinical correlation analysis found that the expression levels of key genes were closely related to eGFR. Immune cell infiltration is higher in samples from patients with DN than in normal samples.Conclusion: We identified and validated 4 DN key genes from disulfidptosis-related genes that CXCL6, CD48, C1QB, and COL6A3 may be key genes that promote the onset of DN and are closely related to the eGFR and immune cell infiltrated in the kidney tissue.

show abstract

Chicoric acid advanced PAQR3 ubiquitination to ameliorate ferroptosis in diabetes nephropathy through the relieving of the interaction between PAQR3 and P110α pathway

Zhang,

Liu,

Zhou

et al. 2024

Clinical and Experimental Hypertension

View full text Add to dashboard Cite

Ferroptosis: a new strategy for Chinese herbal medicine treatment of diabetic nephropathy

Cited by 4 publications

References 249 publications

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

Identification and validation of disulfidptosis-related gene signatures and their subtype in diabetic nephropathy

Chicoric acid advanced PAQR3 ubiquitination to ameliorate ferroptosis in diabetes nephropathy through the relieving of the interaction between PAQR3 and P110α pathway

Contact Info

Product

Resources

About