Ferritin, metabolic syndrome and its components: A systematic review and meta-analysis

Suárez‐Ortegón, Milton Fabian; Ensaldo-Carrasco, Eduardo; Shi, Ting; McLachlan, Stela; Fernández‐Real, José Manuel; Wild, Sarah H.

doi:10.1016/j.atherosclerosis.2018.05.043

Cited by 49 publications

(41 citation statements)

References 52 publications

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“…Our findings are consistent with previous observation, in which the researchers showed that serum concentration of ferritin is connected with insulin resistance in PCOS women (38). Other studies also reported an association between serum ferritin levels and components of insulin resistance (18,22). Additionally, an elevated level of serum ferritin, especially in more insulin-resistant subjects, has been shown (6).…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, elevated serum ferritin levels have been observed in PCOS women (14)(15)(16). In a recent meta-analysis, it has been shown that serum ferritin concentration is connected with fasting plasma glucose, serum insulin concentration (17), and plasma triglycerides (TG) level (18). Additionally, studies revealed that serum ferritin levels are connected with homeostasis model assessment of insulin resistance (HOMA-IR) in a non-diabetic population but not in patients with impaired glucose tolerance (19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

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The Association Between Serum Ferritin Concentration and Visceral Adiposity Estimated by Whole-Body DXA Scan in Women With Polycystic Ovary Syndrome

et al. 2020

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Objective: Women with polycystic ovary syndrome (PCOS) are characterized by insulin resistance and higher prevalence of obesity. Serum ferritin is increased in obesity and is associated with insulin resistance. The aim of the present study was to evaluate the relationships between serum ferritin concentration with insulin resistance and body composition estimated by dual-energy X-ray absorptiometry (DXA) in PCOS women in comparison to the control group. Patients and Methods: One hundred four women were enrolled to the study−65 women with PCOS and 39 women matched for age and BMI as a control group. Serum ferritin concentration and oral glucose tolerance test (OGTT) were performed. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. DXA was performed to estimate fat, fat-free mass, and visceral adipose tissue (VAT). Results: Women with PCOS have higher serum concentration of ferritin (p = 0.002), insulin at baseline (p = 0.03), at 60 min of OGTT (p = 0.01), at 120 min of OGTT (p = 0.004), HOMA-IR (p = 0.03), and VAT (p = 0.0001) in comparison to the control group. We observed a relationship of serum ferritin with insulin concentration at baseline (r = 0.25, p = 0.04) and at 120 min of OGTT (r = 0.31, p = 0.01) and with HOMA-IR (r = 0.30, p = 0.01) in the PCOS group. We noticed an association between serum ferritin concentration and VAT (r = 0.42, p = 0.001), trunk fat mass (r = 0.25, p = 0.04), and android fat mass (r = 0.25, p = 0.04) in the PCOS group. Multiple regression analysis revealed that ferritin (p = 0.02, β = 0.17), insulin at baseline (p = 0.001, β = 0.30), glucose at the 120 min of OGTT (p = 0.007, β = 0.26), and triglycerides (p = 0.001, β = 0.33) were independent predictors of VAT amount in PCOS women. Conclusions: Elevated serum ferritin concentration is connected with insulin resistance as well as with DXA-estimated VAT, android, and trunk fat mass in PCOS women, and could be a marker of metabolic dysfunction.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Association Between Serum Ferritin Concentration and Visceral Adiposity Estimated by Whole-Body DXA Scan in Women With Polycystic Ovary Syndrome

et al. 2020

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“…In other words, there were more CVD risk factors with more plasma ferritin. Furthermore, it has been proven that, of all the MetS components, triglycerides and hyperglycemia are the variables that correlate the most with high plasma ferritin levels [ 37 ]. C reactive protein (CRP) is a protein of the pentraxin family, synthesized and released by endothelial cells in atherosclerotic plaques, hepatocytes, lymphocytes and macrophages, mainly in response to the increase of interleukin 7 (IL 7).…”

Section: Resultsmentioning

confidence: 99%

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

et al. 2020

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Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL®), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy.

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“…In the present study, SF level was positively correlated with total cholesterol, TG, FBG, HOMA-IR, and hs-CRP after adjusting for age and BMI, but the association of MetS did not reach the level of significance after adjustment for BMI. A meta-analysis (Suarez-Ortegon et al, 2018) also found that the meta-regression for ferritin-MetS association identified weaker associations when the studies adjusted for BMI, but the role of adjustment for BMI in evaluating confounding factors should be considered. FAMHES (Tang et al, 2015) has not yet found an association between SF and (Kell & Pretorius, 2018).…”

Section: Discussionmentioning

confidence: 99%

Association of serum ferritin with metabolic syndrome in eight cities in China

Wang

Zhao

Szeto

et al. 2020

Food Science & Nutrition

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Objective This study aims to evaluate the cross‐sectional association of serum ferritin (SF) and the risk of metabolic syndrome (MetS) and its components among adults in eight cities in China. Methods Subjects were recruited using a combination of systematic cluster random sampling and purposive sampling in eight cities in China. The sociodemographic characteristics, data of lifestyle factors, self‐reported disease history, and 24‐hr dietary intake were obtained using a validated questionnaire. Anthropometry was performed, and fasting blood was collected to test the SF, fasting blood glucose (FBG), insulin, high‐sensitivity C‐reactive protein (hs‐CRP), triglycerides (TG), and cholesterols. Logistic and linear regression analyses were conducted to investigate the associations, adjusting for age, city level, smoking, drinking, weekly moderate‐to‐vigorous activity, dietary factors, hs‐CRP, and BMI. Results Serum ferritin level is positively correlated with total cholesterol, TG, FBG, HOMA‐IR, and hs‐CRP after adjusting for age and BMI. The odds ratio (OR) for MetS in the highest quartile of SF was 2.23 (1.32, 3.77) after adjusting for men, compared with the lowest quartile. An elevated ferritin concentration was significantly related to hypertriglyceridemia (p < .001) and elevated glucose (p = .013) among men, but not among women. Furthermore, compared with Q1, the OR for insulin resistance in the ferritin Q4 group was 3.08 (1.50, 6.32) among men and 1.96 (1.19, 3.24) among women. Conclusion A positive association between elevated SF and MetS and its components including hypertriglyceridemia and elevated glucose was found in multivariate analyses among men, and SF levels are independently associated with IR.

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Ferritin, metabolic syndrome and its components: A systematic review and meta-analysis

Abstract: High triglycerides and glucose are the components more strongly associated with ferritin. Hepatic injury and BMI appear to influence the ferritin-MetS association, and a threshold effect of high ferritin concentration on the ferritin-high triglycerides association was observed.

Cited by 49 publications

References 52 publications

The Association Between Serum Ferritin Concentration and Visceral Adiposity Estimated by Whole-Body DXA Scan in Women With Polycystic Ovary Syndrome

The Association Between Serum Ferritin Concentration and Visceral Adiposity Estimated by Whole-Body DXA Scan in Women With Polycystic Ovary Syndrome

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

Association of serum ferritin with metabolic syndrome in eight cities in China

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