Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition

Yu, Xiaoli; Luo, Qihui; Huang, Chao; Shi, Lei; Jahangir, Asad; Pan, Ting; Wei, Xiaoli; He, Junbo; Li, Wentao; Shi, Riyi; Geng, Yi; Fang, Jing; Tang, Li; Guo, Hongrui; Ouyang, Ping; Chen, Zhengli

doi:10.1016/j.ecoenv.2022.114364

Cited by 7 publications

(2 citation statements)

References 61 publications

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“…It has been reported that excess dietary iron could induce intestinal inflammation. However, unlike the decreased bacterial diversity in colitis mice model, a much higher diversity was observed in the HFeD-treated group, which has also been reported previously 56 . We speculate that the high-iron diet may have altered the symbiotic environment in the gut, leading to a significant imbalance in the original ecological niche.…”

Section: Discussionsupporting

confidence: 86%

Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis

et al. 2023

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Dietary iron intake is closely related to the incidence of colorectal cancer. However, the interactions among dietary iron, gut microbiota, and epithelial cells in promoting tumorigenesis have rarely been discussed. Here, we report that gut microbiota plays a crucial role in promoting colorectal tumorigenesis in multiple mice models under excessive dietary iron intake. Gut microbiota modulated by excessive dietary iron are pathogenic, irritating the permeability of the gut barrier and causing leakage of lumen bacteria. Mechanistically, epithelial cells released more secretory leukocyte protease inhibitor (SLPI) to combat the leaked bacteria and limit inflammation. The upregulated SLPI acted as a pro-tumorigenic factor and promoted colorectal tumorigenesis by activating the MAPK signaling pathway. Moreover, excessive dietary iron significantly depleted Akkermansiaceae in the gut microbiota; while supplementation with Akkermansia muciniphila could successfully attenuate the tumorigenic effect from excessive dietary iron. Overall, excessive dietary iron perturbs diet – microbiome–epithelium interactions, which contributes to intestinal tumor initiation.

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Section: Discussionsupporting

confidence: 86%

Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis

et al. 2023

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“…The intestine has a high bacterial abundance, having a diverse range of biochemical and metabolic activities, which interact with the host's physiology. These bacteria aid in breaking down the indigestible polysaccharides and producing vitamins essential for health and are also involved in the development and differentiation of the intestinal epithelium and the host's immune system [78].…”

Section: Effects Of Iron Homeostasis On the Remodeling Of Gut Microbiotamentioning

confidence: 99%

Mechanism of Iron Ion Homeostasis in Intestinal Immunity and Gut Microbiota Remodeling

Bao,

Wang,

Xiong

et al. 2024

IJMS

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Iron is a vital trace element that plays an important role in humans and other organisms. It plays an active role in the growth, development, and reproduction of bacteria, such as Bifidobacteria. Iron deficiency or excess can negatively affect bacterial hosts. Studies have reported a major role of iron in the human intestine, which is necessary for maintaining body homeostasis and intestinal barrier function. Organisms can maintain their normal activities and regulate some cancer cells in the body by regulating iron excretion and iron-dependent ferroptosis. In addition, iron can modify the interaction between hosts and microorganisms by altering their growth and virulence or by affecting the immune system of the host. Lactic acid bacteria such as Lactobacillus acidophilus (L. acidophilus), Lactobacillus rhamnosus (L. rhamnosus), and Lactobacillus casei (L. casei) were reported to increase trace elements, protect the host intestinal barrier, mitigate intestinal inflammation, and regulate immune function. This review article focuses on the two aspects of the iron and gut and generally summarizes the mechanistic role of iron ions in intestinal immunity and the remodeling of gut microbiota.

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Investigation the mechanism of iron overload-induced colonic inflammation following ferric citrate exposure

Xia,

Chen,

Huang

et al. 2024

Ecotoxicology and Environmental Safety

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Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition

Cited by 7 publications

References 61 publications

Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis

Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis

Mechanism of Iron Ion Homeostasis in Intestinal Immunity and Gut Microbiota Remodeling

Investigation the mechanism of iron overload-induced colonic inflammation following ferric citrate exposure

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