Mechanism of Iron Ion Homeostasis in Intestinal Immunity and Gut Microbiota Remodeling

Bao, Honghong; Wang, Yi; Xiong, Hanlin; Xia, Yaoyao; Cui, Zhifu; Liu, Lingbin

doi:10.3390/ijms25020727

Cited by 5 publications

(2 citation statements)

References 157 publications

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“…Anterior LRE cells also showed increased expression of slc40a1 and meltf ( Figure S5K ). Slc11a2 helps regulate the influx of iron into the cell, while ferroportin regulates the export of iron out of the cell ( Yilmaz and Li 2018 ; Bao et al 2024 ). Melanotransferrin has iron-binding properties and is predicted to localize to the plasma membrane, where it transports iron into the cell ( Sekyere et al 2006 ; Dunn, Rahmanto, and Richardson 2007 ).…”

Section: Resultsmentioning

confidence: 99%

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

Childers,

Park,

Wang

et al. 2024

Preprint

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Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has been shown to enhance absorption of nutrients, such as lipids, by intestinal epithelial cells. However, whether protein absorption is also affected by the gut microbiome is poorly understood. Here, we investigate connections between protein absorption and microbes in the zebrafish gut. Using live microscopy-based quantitative assays, we find that microbes slow the pace of protein uptake and degradation in LREs. While microbes do not affect the number of absorbing LRE cells, microbes lower the expression of endocytic and protein digestion machinery in LREs. Using transgene assisted cell isolation and single cell RNA-sequencing, we characterize all intestinal cells that take up dietary protein. We find that microbes affect expression of bacteria-sensing and metabolic pathways in LREs, and that some secretory cell types also take up protein and share components of protein uptake and digestion machinery with LREs. Using custom-formulated diets, we investigated the influence of diet and LRE activity on the gut microbiome. Impaired protein uptake activity in LREs, along with a protein-deficient diet, alters the microbial community and leads to increased abundance of bacterial genera that have the capacity to reduce protein uptake in LREs. Together, these results reveal that diet-dependent reciprocal interactions between LREs and the gut microbiome regulate protein absorption.

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Section: Resultsmentioning

confidence: 99%

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

Childers,

Park,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…However, due to the first-pass effect of hepatic portal circulation, iron exposure in the liver is much greater than in other tissues, resulting in liver damage and various complications. Thus, changes in iron metabolism, resulting in fluctuations in its serum level, can potentially influence the occurrence of ferroptosis [77,211,212].…”

Section: Ferroptosis and The Intestinal Microbiotamentioning

confidence: 99%

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

De Cól,

de Lima,

Pompeu

et al. 2024

IJMS

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Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and fatty liver dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, and metabolic syndrome are frequently present; these conditions are related to liver lipogenesis and systemic inflammation. This study aimed to review the connection between the brain–gut–liver axis and MAFLD. The inflammatory process, cellular alterations in hepatocytes and stellate cells, hypercaloric diet, and sedentarism aggravate the prognosis of patients with MAFLD. Thus, to understand the modulation of the physiopathology of MAFLD, it is necessary to include the organokines involved in this process (adipokines, myokines, osteokines, and hepatokines) and their clinical relevance to project future perspectives of this condition and bring to light new possibilities in therapeutic approaches. Adipokines are responsible for the activation of distinct cellular signaling in different tissues, such as insulin and pro-inflammatory cytokines, which is important for balancing substances to avoid MAFLD and its progression. Myokines improve the quantity and quality of adipose tissues, contributing to avoiding the development of MAFLD. Finally, hepatokines are decisive in improving or not improving the progression of this disease through the regulation of pro-inflammatory and anti-inflammatory organokines.

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Sialylation in the gut: From mucosal protection to disease pathogenesis

Ma,

Li,

Wang

et al. 2024

Carbohydrate Polymers

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Mechanism of Iron Ion Homeostasis in Intestinal Immunity and Gut Microbiota Remodeling

Cited by 5 publications

References 157 publications

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

Sialylation in the gut: From mucosal protection to disease pathogenesis

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