Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice

Cheng, Yuxin; Wu, Ting; Tang, Shuxin; Liang, Fuqiang; Fang, Yajing; Cao, Weiwei; Pan, Siyi; Xu, Xiaoyun

doi:10.1039/c9fo02517k

Cited by 34 publications

(43 citation statements)

References 65 publications

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“…Intake of high-fat foods has been reported to induce changes in the intestinal flora, thereby increasing intestinal permeability, a significant factor in the onset of Crohn’s disease [ 35 ]. NF-κB, a critical transcriptional regulator of the inflammatory response, is also a crucial factor in intestinal inflammation [ 36 ] and is activated by various stimuli, including inflammatory cytokines such as TNF and pathogen-derived molecules [ 37 ]. In the present study, we demonstrated that administration of Lactobacillus plantarum strains ATG-K2 and ATG-K6 reduced HFHF diet-induced small-intestine inflammation by regulating pro-inflammatory cytokines in animal models.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Park

Kim

et al. 2021

IJMS

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Obesity has become a worldwide health problem, and many significant inflammatory markers have been associated with the risk of side effects of obesity and obesity-related diseases. After a normal diet or high-fat diet with high-fructose water (HFHF) for 8 weeks, male Wistar rats were divided randomly into four experimental groups according to body weight. Next, for 8 weeks, a normal diet, HFHF diet, and HFHF diet with L. plantarum strains ATG-K2 or ATG-K6 were administered orally. Compared to the control group, the HFHF diet group showed significantly increased visceral fat, epididymal fat, and liver weight. The mRNA and protein expression levels of FAS and SREBP-1c were higher in the HFHF diet group than in the HFHF diet with L. plantarum strains ATG-K2 and ATG-K6. The HFHF diet with L. plantarum strain ATG-K2 showed significantly decreased inflammatory cytokine expression in the serum and small intestine compared to the HFHF diet group. Furthermore, histological morphology showed minor cell injury, less severe infiltration, and longer villi height in the small intestine ileum of the HFHF diet with L. plantarum strains groups than in the HFHF diet group. These results suggest that L. plantarum strains K2 and K6 may help reduce intestinal inflammation and could be used as treatment alternatives for intestinal inflammatory reactions and obesity.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Park

Kim

et al. 2021

IJMS

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“…Therefore, fermented blueberries increased sIgA level by improving gut microbiota and SCFAs production [ 85 ]. Moreover, this product has been shown to counteract intestinal inflammation by the reduction of TNF-α and myeloperoxidase and inducing interleukin (IL-10) production and improved gut barrier function and immunity by regulating NF-κB/myosin light-chain kinase (MLCK) signaling [ 87 ] and the overexpression of MLCK results in gut barrier permeability and dysfunction [ 87 , 88 ].…”

Section: Fermented Berriesmentioning

confidence: 99%

Anti-Inflammatory and Immunomodulatory Properties of Fermented Plant Foods

et al. 2021

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Fermented plant foods are gaining wide interest worldwide as healthy foods due to their unique sensory features and their health-promoting potentials, such as antiobesity, antidiabetic, antihypertensive, and anticarcinogenic activities. Many fermented foods are a rich source of nutrients, phytochemicals, bioactive compounds, and probiotic microbes. The excellent biological activities of these functional foods, such as anti-inflammatory and immunomodulatory functions, are widely attributable to their high antioxidant content and lactic acid-producing bacteria (LAB). LAB contribute to the maintenance of a healthy gut microbiota composition and improvement of local and systemic immunity. Besides, antioxidant compounds are involved in several functional properties of fermented plant products by neutralizing free radicals, regulating antioxidant enzyme activities, reducing oxidative stress, ameliorating inflammatory responses, and enhancing immune system performance. Therefore, these products may protect against chronic inflammatory diseases, which are known as the leading cause of mortality worldwide. Given that a large body of evidence supports the role of fermented plant foods in health promotion and disease prevention, we aim to discuss the potential anti-inflammatory and immunomodulatory properties of selected fermented plant foods, including berries, cabbage, and soybean products, and their effects on gut microbiota.

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“…The metabolic bacteria associated with SCFAs were Bifidobacterium and Akkermansia, among others, which could reduce the colon pH, inhibit the growth of intestinal pathogenic bacteria, participate in the synthesis of cholesterol, and provide energy for colonic epithelial cells. 32,33 This result shows that a certain dose of stachyose has the function of protecting colon tissues and promoting the growth of epithelial cells. Simultaneously, we found that the relative abundance of acetic acid-producing Blautia was significantly increased after stachyose intake.…”

Section: Discussionmentioning

confidence: 84%

Microbiome‐metabolomic analyses of the impacts of dietary stachyose on fecal microbiota and metabolites in infants intestinal microbiota‐associated mice

Tang

Zhang

et al. 2021

J Sci Food Agric

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BACKGROUND: The intestinal microbiota and metabolites play an important role in human health and immunity. However, few studies have investigated the long-term effects of stachyose on the human intestinal microbiota and metabolism. Therefore, in this study, the feces of infants were transplanted into germ-free mice, and the effect of long-term stachyose intake on intestinal metabolism was examined by comparing the results of microbiome and metabolome analyses. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used to study the effects of stachyose intake on the metabolites and metabolic pathways of the transplanted human intestinal microbiota. RESULTS:We observed that stachyose significantly altered the composition of the intestinal microbiota and metabolites, upregulated production of the metabolite taurocholic acid, down-regulated amino acid metabolism, and significantly regulated the metabolism of taurine and hydroxytaurine, pantothenate and coenzyme A (CoA) biosynthesis, and other signaling pathways.CONCLUSION: These findings may provide a basis for elucidating the mechanism by which stachyose promotes host health.

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Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice

Abstract: The barrier-improving functions of fermented blueberry pomace (FBP) and its potential mechanism were investigated in this study.

Cited by 34 publications

References 65 publications

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Lactobacillus plantarum ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation

Anti-Inflammatory and Immunomodulatory Properties of Fermented Plant Foods

Microbiome‐metabolomic analyses of the impacts of dietary stachyose on fecal microbiota and metabolites in infants intestinal microbiota‐associated mice

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