Fermentative Production of Plant Benzylisoquinoline Alkaloids in Microbes

Minami, Hiromichi

doi:10.1271/bbb.130106

Cited by 20 publications

(18 citation statements)

References 40 publications

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“…Synthetic biology is often defined as the application of engineering design principles to biology [58]. Synthetic biology can be used to design organisms or systems to effectively produce biological compounds, including for use in food [59] and thus represents a promising platform for the development and synthesis of new antimicrobial compounds, including compounds that could be used in foods, such as bacteriocins. For example, synthetic biology could be used to facilitate synthesis of novel types of leaderless bacteriocins [60].…”

Section: Combination Of Synthetic Biology and Omics Approaches Providmentioning

confidence: 99%

Omics approaches in food safety: fulfilling the promise?

Bergholz

Switt

Wiedmann

2014

Trends in Microbiology

104

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Genomics, transcriptomics, and proteomics are rapidly transforming our approaches to detection, prevention and treatment of foodborne pathogens. Microbial genome sequencing in particular has evolved from a research tool into an approach that can be used to characterize foodborne pathogen isolates as part of routine surveillance systems. Genome sequencing efforts will not only improve outbreak detection and source tracking, but will also create large amounts of foodborne pathogen genome sequence data, which will be available for data mining efforts that could facilitate better source attribution and provide new insights into foodborne pathogen biology and transmission. While practical uses and application of metagenomics, transcriptomics, and proteomics data and associated tools are less prominent, these tools are also starting to yield practical food safety solutions.

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Section: Combination Of Synthetic Biology and Omics Approaches Providmentioning

confidence: 99%

Omics approaches in food safety: fulfilling the promise?

Bergholz

Switt

Wiedmann

2014

Trends in Microbiology

104

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“…It is probable that functional genomics for alkaloid production is in full swing due to the recent studies validating their high scale production in genetically modified microorganisms as E. coli and S. cerevisiae [62]. Role of cytochrome P450 enzymes in alkaloids biosynthesis are quite specific compared with those involved in the biosynthesis of flavonoids and terpenes.…”

Section: Resultsmentioning

confidence: 99%

Cytochrome P450 from Plants: Platforms for Valuable Phytopharmaceuticals

Villa‐Ruano¹,

Pacheco‐Hernández²,

Lozoya‐Gloria³

et al. 2015

Trop. J. Pharm Res

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“…Considering that Benzylisoquinoline alkaloids are plant metabolites that are present in plant cells [53], its presence in the palm wine may be from the palm tree from which the palm wine was obtained. More knowledge may be gained if an investigation is carried out to establish if Saccharomyces cerevisiae from palm wine can naturally synthesize the compound.…”

Section: -Methyl-67-benzylisoquinolinementioning

confidence: 99%

Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards

Nwaiwu

Itumoh²

2017

Beverages

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Recent analysis of palm wine, a traditional drink fermented mainly by yeasts, revealed the presence of several chemicals that were not products of yeast fermentation. The chemicals included styrene, benzene, trimethyldioxolane, dichloromethane, methylene fluoride, dichloroethanol, benzylisoquinoline and tetraacetyl-D-xylonic nitrile. A review of the concentrations of these compounds in palm wine found that the benzene concentrations in all samples reviewed ranged from 56-343 ppm and were within permissible limits, whereas the styrene values (1505-5614 ppm) in all the palm wine samples evaluated were well over the recommended concentration that is immediately dangerous to life or health. Other chemical compounds evaluated varied according to location or sample source. The concentrations obtained are estimates only and a quantitative study needs to be carried out before the impact of these chemicals on health is evaluated. A search on The PubChem Project, the open chemical database, showed the description, properties and uses of these chemicals. Further searches carried out within other databases like PubMed, Scopus and Google Scholar, using each chemical's name as a search term, showed possible hazards and adverse health conditions caused by these chemicals, especially styrene, benzene and dichloromethane. The point at which the chemicals are introduced into the drink is still not clear and requires further investigation. The chemicals can be hazardous to humans and there is need to establish and maintain a system that can guarantee permissible levels in the drink. This can be carried out using concentrations of the chemicals that are already known to be immediately dangerous to life or health as a reference point.

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Fermentative Production of Plant Benzylisoquinoline Alkaloids in Microbes

Cited by 20 publications

References 40 publications

Omics approaches in food safety: fulfilling the promise?

Omics approaches in food safety: fulfilling the promise?

Cytochrome P450 from Plants: Platforms for Valuable Phytopharmaceuticals

Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards

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