Fermentation, isolation, and biological activity of maduramycin: A new antibiotic from <i>Actinomadura rubra</i>

Fleck, W. F.; Strauss, D.; Meyer, J.; Porstendorfer, Gisela

doi:10.1002/jobm.19780180602

Cited by 14 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First evidence of antibacterial actinotiocin was found to be produced by the type species of the genus, N. pusilla IFO 14684 T [40]. Later on, Fleck et al [41] found a potent anti-Grampositive, maduramycin (Fig. 1a) produced by N. rubra DSM 43768 T [5].…”

Section: Antimicrobial Substancesmentioning

confidence: 99%

The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites

Sungthong

Nakaew

2014

J. Basic Microbiol.

View full text Add to dashboard Cite

The genus Nonomuraea is a rare actinomycete taxon with a long taxonomic history, while its generic description was recently emended. The genus is less known among the rare actinomycete genera as its taxonomic position was revised several times. It can be found in diverse ecological niches, while most of its member species were isolated from soil samples. However, new trends to discover the genus in other habitats are increasing. Generic abundance of the genus was found to be dependent on geographical changes. Novel sources together with selective and invented isolation techniques might increase a chance to explore the genus and its novel candidates. Interestingly, some of its members have been revealed as a valuable source of novel metabolites for medical and industrial purposes. Broad-range of potent bioactive compounds including antimicrobial, anticancer, and antipsychotic substances, broad-spectrum antibiotics and biocatalysts can be synthesized by the genus. In order to investigate biosynthetic pathways of the bioactive compounds and self-resistant mechanisms to these compounds, the links from genes to metabolites have yet been needed for further discovery and biotechnological development of the genus Nonomuraea.

show abstract

Section: Antimicrobial Substancesmentioning

confidence: 99%

The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites

Sungthong

Nakaew

2014

J. Basic Microbiol.

View full text Add to dashboard Cite

show abstract

“…Table 1 illustrates the spectrum of activity of ireiiiycin and doxorubicin against a range of 19 strains of microorganisms. Many of the strains listed have been studied in some detail in these laboratories and data on susceptibility against different antibiotics have been reported (FLECK et al 1978).…”

mentioning

confidence: 99%

New anthracycline antibiotics produced by interspecific recombinants of streptomycetes. IV. Antimicrobial activity of iremycin

Fleck¹,

Schlegel²,

Ihn³

1982

Z Allg Mikrobiol

Self Cite

View full text Add to dashboard Cite

The in vitro antimicrobial activity of iremycin (10-(alpha-L-rhodosaminyl)-gamma-rhodomycinone) was determined in comparison to that of doxorubicin, a 14-hydroxy-derivative of daunorubicin, which exhibited a strong antitumor activity and is useful in chemotherapy of human tumors. The MIC values determined by means of a standardized agar diffusion plate test indicated a lower antimicrobial activity of iremycin in vitro in comparison to that of doxorubicin. In contrast to doxorubicin, iremycin was highly active against Mycobacterium smegmatis, but five-fold less active than doxorubicin against Staphylococcus aureus, seven-fold less active against Bacillus subtilis, and twenty five-fold less active against Commamonas terrigena. Furthermore, iremycin was hundred-fold less active against a highly sensitive permeation mutant of Pseudomonas aeruginosa. No inducing activity on prophages in lysogenic E. coli cells was demonstrable for iremycin and no growth inhibition in the repair test was observable. In contrast, iremycin inhibited the multiplication of gamma-phages in the BIP test, but the MIC values of violamycin BI, doxorubicin and iremycin in this test system indicated that iremycin is two hundred fifty-fold less active than violamycin BI and ten-fold less active than doxorubicin. No serum binding was demonstrable for iremycin.

show abstract

“…

Es werden derzeit 21 Arten der noch jungen Gattung Aetinomadura unterschieden (PREOBRAZSHENSKAYA et al 1977), von denen erst in 6 Fallen die Bildung eines Antibioticums bekannt ist (FLECK et al 1978). Maduramycin ist eines dieser Antibiotica, das von Actinomadura rubra (SVESHNIKOVA et al) J .

…”

unclassified

“…MEYER et SVESHNIKOVA 1974 gebildet wird. Seine Fermentation, Isolierung und Eigenschaften wurden bereits beschrieben (STRAWS et al 1976, 1978). Das rote Pigment-Antibioticum Maduramycin hemmt bevorzugt das Wachstum von grampositiven Bakterien.…”

unclassified

See 1 more Smart Citation

Wirkungsweise von Maduramycin auf die T3‐Phagen‐spezifische RNA‐Synthese in vitro

Brux

Michel

Mann

et al. 1978

J of Basic Microbiology

Self Cite

View full text Add to dashboard Cite

show abstract

Fermentation, isolation, and biological activity of maduramycin: A new antibiotic from Actinomadura rubra

Cited by 14 publications

References 16 publications

The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites

The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites

New anthracycline antibiotics produced by interspecific recombinants of streptomycetes. IV. Antimicrobial activity of iremycin

Wirkungsweise von Maduramycin auf die T3‐Phagen‐spezifische RNA‐Synthese in vitro

Contact Info

Product

Resources

About