Fermentable fibres condition colon microbiota and promote diabetogenesis in NOD mice

Abstract

FFs condition microbiota, affect colon homeostasis and are important components of natural, diabetes-promoting diets in NOD mice.

On the role of gut bacteria and infant diet in the development of autoimmunity for type 1 diabetes

“…In terms of disease-promoting mechanisms, our findings alluded to a pathophysiological model [6] well aligned with the model recently discussed by Davis-Richardson and Triplett in Diabetologia [3]. The core idea is that, by displacing beneficial butyrate-producing taxa, Bacteroidetes have adverse effects on epithelial cells [3,6]. Our findings provided experimental evidence in support of this and indicated that at least some Bacteroides species play a role in diabetes-related autoimmunity.…”

“…Pectin and xylan dramatically increased colonisation of the intestine by Bacteroidetes, including B. dorei ( Fig. 1 and data in [6]), increased the expression of stress-related molecular transcripts and inflammatory cytokines in the gut, and altered the balance of T cell cytokines in pancreatic lymph nodes. In terms of disease-promoting mechanisms, our findings alluded to a pathophysiological model [6] well aligned with the model recently discussed by Davis-Richardson and Triplett in Diabetologia [3].…”

“…We have studied the effect of two common nutritional fibres, pectin and xylan, on microbial colonisation, gut homeostasis and diabetes development in NOD mice [6]. Pectin and xylan dramatically increased colonisation of the intestine by Bacteroidetes, including B. dorei ( Fig.…”

“…1 and data in [6]), increased the expression of stress-related molecular transcripts and inflammatory cytokines in the gut, and altered the balance of T cell cytokines in pancreatic lymph nodes. In terms of disease-promoting mechanisms, our findings alluded to a pathophysiological model [6] well aligned with the model recently discussed by Davis-Richardson and Triplett in Diabetologia [3]. The core idea is that, by displacing beneficial butyrate-producing taxa, Bacteroidetes have adverse effects on epithelial cells [3,6].…”

On the role of gut bacteria and infant diet in the development of autoimmunity for type 1 diabetes. Reply to Hänninen ALM and Toivonen RK [letter]

“…This is based on their recent study in the NOD mouse [4], the idea being that fibre in the diet may be an important component leading to type 1 diabetes and that this may be conferred by an increase in the Bacteroides population in the NOD mouse. It is not clear whether this work in mice is translatable to the human condition.…”