On the role of gut bacteria and infant diet in the development of autoimmunity for type 1 diabetes. Reply to Hänninen ALM and Toivonen RK [letter]

Davis-Richardson, Austin G.; Triplett, Eric W.

doi:10.1007/s00125-015-3701-x

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…2 In recent years, several studies have found that these microorganisms play an important role in the health of the host. 3 Diseases related to the immune system, such as autoimmune diabetes (type 1), 4 some types of cancer, 5 kidney disease, 6 liver disease, 7 gastrointestinal disorder, 2 and obesity 8 have been related to the intestinal microbiota. It is well known that the relationship between the immune system and the host is bilateral and this relationship allows alterations in the intestinal microbiota to be associated with the pathogenesis that compromises health.…”

Section: Introductionmentioning

confidence: 99%

Overfeeding a High-Fat Diet Promotes Sex-Specific Alterations on the Gut Microbiota of the Zebrafish (Danio rerio)

et al. 2019

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Diet modulates the gut microbiota and is one of the main factors promoting obesity and overweight. In the present study, we investigated the effect of a high-fat diet (HFD) on the gut microbiota of the zebrafish (Danio rerio). Fish were separated into three groups and fed in different regimes: low fat, high fat, and high fat overfed; the experiments were performed on males and females separately. We analyzed more than 2.6 million sequences of variable region V3 of the 16S rRNA gene generated by the Illumina Miniseq platform, clustered to 97% similarity with vsearch and classified with the EzBioCloud database. The weight gain, condition factor (K), and body mass index were calculated as indicators of obesity. Multivariate analysis (PERMANOVA and ANOSIM) and diversity indices (Shannon and Dominance) revealed that overfeeding a HFD disturbs the gut microbiota differently in males and females suggesting that sex is a significant factor (p < 0.05) for the composition of the gut microbiota of zebrafish. The results also indicate that a HFD provided in a basal caloric regime does not promote obesity or alterations in the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Overfeeding a High-Fat Diet Promotes Sex-Specific Alterations on the Gut Microbiota of the Zebrafish (Danio rerio)

et al. 2019

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“…Accordingly, evidence obtained from both animal models and human studies suggests that the gut microbiota and the immune system interact closely, emphasizing the role of the intestinal microbiota in the maturation and development of immune functions 16 . Recently, mycobiomebacteriome interactions, as well as intestinal virome and islet autoimmunity, were hypothesized to be drivers of dysbiosis 17 . Several studies have specifically investigated microbiota composition in children with T1D [18][19][20] , but the results have not been consistent.…”

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confidence: 99%

Risk factors for type 1 diabetes, including environmental, behavioural and gut microbial factors: a case–control study

Traversi

Rabbone

Scaioli

et al. 2020

Sci Rep

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Type 1 diabetes (T1D) is a common autoimmune disease that is characterized by insufficient insulin production. The onset of T1D is the result of gene-environment interactions. Sociodemographic and behavioural factors may contribute to T1D, and the gut microbiota is proposed to be a driving factor of T1D. An integrated preventive strategy for T1D is not available at present. This case–control study attempted to estimate the exposure linked to T1D to identify significant risk factors for healthy children. Forty children with T1D and 56 healthy controls were included in this study. Anthropometric, socio-economic, nutritional, behavioural, and clinical data were collected. Faecal bacteria were investigated by molecular methods. The findings showed, in multivariable model, that the risk factors for T1D include higher Firmicutes levels (OR 7.30; IC 2.26–23.54) and higher carbohydrate intake (OR 1.03; IC 1.01–1.05), whereas having a greater amount of Bifidobacterium in the gut (OR 0.13; IC 0.05 – 0.34) was a protective factor for T1D. These findings may facilitate the development of preventive strategies for T1D, such as performing genetic screening, characterizing the gut microbiota, and managing nutritional and social factors.

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Vegetarian Diets and the Microbiome

Orlich

Segovia‐Siapco

Jung

2017

Vegetarian and Plant-Based Diets in Health and Disease Prevention

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On the role of gut bacteria and infant diet in the development of autoimmunity for type 1 diabetes. Reply to Hänninen ALM and Toivonen RK [letter]

Cited by 4 publications

References 9 publications

Overfeeding a High-Fat Diet Promotes Sex-Specific Alterations on the Gut Microbiota of the Zebrafish (Danio rerio)

Overfeeding a High-Fat Diet Promotes Sex-Specific Alterations on the Gut Microbiota of the Zebrafish (Danio rerio)

Risk factors for type 1 diabetes, including environmental, behavioural and gut microbial factors: a case–control study

Vegetarian Diets and the Microbiome

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