FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

Xu, Chen; Yuan, Zhiquan; Kohler, Nathan; Kim, Jaemin; Chung, Maureen A.; Sun, Shouheng

doi:10.1021/ja905938a

Cited by 187 publications

(168 citation statements)

References 41 publications

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“…35,[38][39][40][41] Furthermore, in the area of medical imaging, FePt NPs are considered to have great potential in MRI and MRI/CT dual-model imaging as a regenerative medicine. 31,33 However, we confirm that there is still a paucity of research on FePt NPs in the radiotherapy field, in which the NPs may hold potential.…”

Section: Discussionmentioning

confidence: 99%

“…The results displayed in Figures 2 and 3 indicate that the FePt NPs show significant cytotoxicity on HeLa cells, while not significantly suppressing the proliferation of Vero cells at a concentration below 250 μg/mL. Previously, Xu et al 38 suggested that FePt NPs showed the controlled release in a low pH solution, while there was little degradation of FePt NPs in a solution of pH 7.4. Gao et al 29 indicated that, in HeLa cells, the FePt cores of FePt@CoS 2 were oxidized and degraded in secondary lysosome with a low-pH environment.…”

mentioning

confidence: 85%

“…The ROS, such as the hydroxyl radical (•OH) and carboxyl radical (•OOH), are powerful agents for damaging various matter in cells, leading to cell death. 27,38 Therefore, FePt NPs may have potential to act as chemotherapy agents to kill tumor cells. As demonstrated in the current study, FePt NPs combined with X-ray beams suppressed the proliferation of HeLa cells more efficiently as a radiosensitizer (Figure 4).…”

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confidence: 99%

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FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

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Nanomaterials have an advantage in “personalized” therapy, which is the ultimate goal of tumor treatment. In order to investigate the potential ability of FePt nanoparticles (NPs) in the diagnosis and chemoradiotherapy treatment of malignant tumors, superparamagnetic, monodispersed FePt (~3 nm) alloy NPs were synthesized, using cysteamine as a capping agent. The NPs were characterized by means of X-ray diffraction; transmission electron microscopy, Physical Property Measurement System, and Fourier transform infrared spectroscopy. The cytotoxicity of FePt NPs on Vero cells was assessed using an MTT assay, and tumor cell proliferation inhibited by individual FePt NPs and FePt NPs combined with X-ray beams were also collected using MTT assays; HeLa human cancer cell lines were used as in vitro models. Further confirmation of the combined effect of FePt NPs and X-rays was verified using HeLa cells, after which, the cellular uptake of FePt NPs was captured by transmission electron microscopy. The results indicated that the growth of HeLa cells was significantly inhibited by FePt NPs in a concentration-dependent manner, and the growth was significantly more inhibited by FePt NPs combined with a series of X-ray beam doses; the individual NPs did not display any remarkable cytotoxicity on Vero cells at a concentration <250 μg/mL. Meanwhile, the FePt NPs showed negative/positive contrast enhancement for MRI/CT molecule imaging at the end of the study. Therefore, the combined results implied that FePt NPs might potentially serve as a promising nanoprobe for the integration of tumor diagnosis and chemoradiotherapy.

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Section: Discussionmentioning

confidence: 99%

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confidence: 85%

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confidence: 99%

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FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

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“…[1][2][3][4][5][6][7][8][9][10] Recent studies indicate that NdFeB, 11 and hexagonal SmCo 12 -based alloy NPs are ideal building blocks for fabricating nanostructured permanent magnet due to strong ferromagnetism observed within their unique structure. However, rare-earth metal-based alloy NPs of SmCo and NdFeB are extremely difficult to prepare and stabilize due to the easy oxidation of Sm(0) and Nd(0) in the alloy structures.…”

Section: Introductionmentioning

confidence: 99%

Direct chemical synthesis of L1₀-FePtAu nanoparticles with high coercivity

Mukherjee

Tian

et al. 2014

Nanoscale

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We report a facile synthesis of hard magnetic L10-FePtAu nanoparticles by coreduction of Fe(acac)3, Pt(acac)2 (acac = acetylacetonate), and gold acetate in oleylamine. In the current reaction condition, NP sizes are controlled to be 5.5 to 11.0 nm by changing the amount of Au doping. When the Au composition in the NPs is higher than 14%, the hard magnetic NPs are directly obtained without any annealing. The highest coercivity of 12.15 kOe at room temperature could be achieved for the NPs with 32% Au doping, which is much higher than the coercivities reported by the previous studies on solution-synthesized FePt nanoparticles. The reported one-pot synthesis of L10-FePtAu NPs may help to build superstrong magnets for magnetic or data-storage applications.

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“…19,23 Additionally, FePt NPs significantly suppress the proliferation of various tumor cells, such as human ovarian cancer cells (A2780), human epithelial carcinoma cells (A431), human breast cancer cells (Sk-Br3), and human embryonic kidney cells (HEK-293). 24 Thus, superparamagnetic FePt NPs could be considered good candidates for developing multi-functional nanomedicines for the diagnosis and therapy of malignant gliomas.…”

Section: Introductionmentioning

confidence: 99%

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

Sun¹,

Chen²,

Chen³

et al. 2012

IJN

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Malignant gliomas are primary brain tumors with high rates of morbidity and mortality; they are the fourth most common cause of cancer death. Novel diagnostic and therapeutic techniques based on nanomaterials provide promising options in the treatment of malignant gliomas. In order to evaluate the potential of FePt nanoparticles (NPs) for malignant glioma therapy, FePt NPs with different surface coatings and components were tunably synthesized using oleic acid/oleylamine (OA/OA) and cysteines (Cys) as the capping agents, respectively. The samples were characterized using X-ray diffraction, transmission electron microscopy (TEM), X-ray photon spectroscopy, Fourier transform infrared spectroscopy, atomic absorption spectrum, and zeta potential. The influence of the surface coatings and components of the FePt NPs on the proliferation of glioma cells was assessed through MTT assay and TEM observation using three typical glioma cell lines (glioma U251 cells, astrocytoma U87 cells, and neuroglioma H4 cells) as in vitro models. The results showed that the proliferation of glioma cells was significantly suppressed by lipophilic FePt-OA/OA NPs in a time-and/or dose-dependent manner, while no or low cytotoxic effects were detected in the case of hydrophilic FePt-Cys NPs. The IC 50 value of FePt-OA/OA NPs on the three glioma cell lines was approximately 5-10 µg mL −1 after 24 hours' incubation. Although the cellular uptake of FePt NPs was confirmed regardless of the surface coatings and components of the FePt NPs, the suppression of FePt NPs on glioma cell proliferation was dominantly determined by their surface coatings rather than their components.Therefore, these results demonstrate that, through engineering of the surface coating, FePt NPs can potentially be developed as novel therapeutic agents for malignant gliomas.

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FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

Cited by 187 publications

References 41 publications

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Direct chemical synthesis of L1₀-FePtAu nanoparticles with high coercivity

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

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FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

Cited by 187 publications

References 41 publications

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Direct chemical synthesis of L10-FePtAu nanoparticles with high coercivity

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

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Direct chemical synthesis of L1₀-FePtAu nanoparticles with high coercivity