FeOOH@Metal–Organic Framework Core–Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers

Pei, Congcong; Liu, Chao; Wang, You; Cheng, Dan; Li, Rongxin; Shu, Weikang; Zhang, Chaoqi; Hu, Wenli; Jin, Aihua; Yang, Yannan; Wan, Jingjing

doi:10.1002/ange.202001135

Cited by 22 publications

(16 citation statements)

References 67 publications

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“…Efforts will be made in the future to provide deeper insight into the various scientific issues regarding food safety, such as the ADME of agrochemicals in food tissues. Beyond that, numerous possibilities remain for multifunctional nanocomposites with synergistic effects [ 50 , 51 ] for tissue imprinting imaging, especially in life science and environmental science.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

Qin

et al. 2021

Nanomaterials

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Food safety issues caused by pesticide residue have exerted far-reaching impacts on human daily life, yet the available detection methods normally focus on surface residue rather than pesticide penetration to the internal area of foods. Herein, we demonstrated gold nanoparticle (AuNP)-immersed paper imprinting mass spectrometry imaging (MSI) for monitoring pesticide migration behaviors in various fruits and vegetables (i.e., apple, cucumber, pepper, plum, carrot, and strawberry). By manually stamping food tissues onto AuNP-immersed paper, this method affords the spatiotemporal visualization of insecticides and fungicides within fruits and vegetables, avoiding tedious and time-consuming sample preparation. Using the established MSI platform, we can track the migration of insecticides and fungicides into the inner region of foods. The results revealed that both the octanol-water partition coefficient of pesticides and water content of garden stuffs could influence the discrepancy in the migration speed of pesticides into food kernels. Taken together, this nanopaper imprinting MSI is poised to be a powerful tool because of its simplicity, rapidity, and easy operation, offering the potential to facilitate further applications in food analysis. Moreover, new perspectives are given to provide guidelines for the rational design of novel pesticide candidates, reducing the risk of food safety issues caused by pesticide residue.

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Section: Discussionmentioning

confidence: 99%

Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

Qin

et al. 2021

Nanomaterials

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“…Very recently, Pei et al. fabricated FeOOH@ZIF-8 nanocomposites as LDI-MS matrix by encapsulating FeOOH nanorods with zeolitic imidazolate framework (ZIF-8) crystals [ 101 ] ( Fig. 7 A).…”

Section: Metabolitesmentioning

confidence: 99%

Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

Yang

Huang

Xiao

et al. 2022

Materials Today Bio

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“…Capturing, characterization, and enumeration of CTCs were considered as prognostic biomarkers in tumor metastasis and a promising method for early cancer diagnostics [ 4 , 5 ]. Compared with other early cancer diagnostic tools, such as genetic or metabolite omics analysis [ 6 – 8 ], captured CTCs could provide more information for further analysis. However, the limited sensitivity of commercially available approaches combined with the disease's complexity and heterogeneity had restricted the broad acceptance and dissemination of CTC-based diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Immunoengineered magnetic-quantum dot nanobead system for the isolation and detection of circulating tumor cells

et al. 2021

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Background Highly efficient capture and detection of circulating tumor cells (CTCs) remain elusive mainly because of their extremely low concentration in patients’ peripheral blood. Methods We present an approach for the simultaneous capturing, isolation, and detection of CTCs using an immuno-fluorescent magnetic nanobead system (iFMNS) coated with a monoclonal anti-EpCAM antibody. Results The developed antibody nanobead system allows magnetic isolation and fluorescent-based quantification of CTCs. The expression of EpCAM on the surface of captured CTCs could be directly visualized without additional immune-fluorescent labeling. Our approach is shown to result in a 70–95% capture efficiency of CTCs, and 95% of the captured cells remain viable. Using our approach, the isolated cells could be directly used for culture, reverse transcription-polymerase chain reaction (RT-PCR), and immunocytochemistry (ICC) identification. We applied iFMNS for testing CTCs in peripheral blood samples from a lung cancer patient. Conclusions It is suggested that our iFMNS approach would be a promising tool for CTCs enrichment and detection in one step. Graphic abstract

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FeOOH@Metal–Organic Framework Core–Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.

Cited by 22 publications

References 67 publications

Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

Immunoengineered magnetic-quantum dot nanobead system for the isolation and detection of circulating tumor cells

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