Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

Yang, Yuqi; Huang, Qiong; Xiao, Zhu; Liu, Min; Zhu, Yan; Chen, Qiaohui; Li, Yumei; Ai, Kelong

doi:10.1016/j.mtbio.2022.100218

Cited by 31 publications

(25 citation statements)

References 144 publications

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“…Surface-Enhanced Raman Spectroscopy lateral flow immunoassays (SERS-based LFIAs) performed on properly functionalized membranes, which may themselves be considered as a type of optical immunosensor, have been described in a review article presenting Raman Scattering-based biosensors [ 51 ]. Optical immunosensors employing appropriate dendrimers [ 52 ] or various nanomaterials [ 53 ] as a means of improving sensing efficiency/sensitivity have been presented in recent reviews.…”

Section: Newest Developments In Optical Immunosensors: Bioanalytical ...mentioning

confidence: 99%

Recent Developments in the Field of Optical Immunosensors Focusing on a Label-Free, White Light Reflectance Spectroscopy-Based Immunosensing Platform

Karachaliou

Koukouvinos

Goustouridis

et al. 2022

Sensors

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Optical immunosensors represent a research field of continuously increasing interest due to their unique features, which can mainly be attributed to the high-affinity and specific antibodies they use as biorecognition elements, combined with the advantageous characteristics of the optical transducing systems these sensors employ. The present work describes new developments in the field, focusing on recent bioanalytical applications (2021–2022) of labeled and label-free optical immunosensors. Special attention is paid to a specific immunosensing platform based on White Light Reflectance Spectroscopy, in which our labs have gained specific expertise; this platform is presented in detail so as to include developments, improvements, and bioanalytical applications since the mid-2000s. Perspectives on the field are been briefly discussed as well, highlighting the potential of optical immunosensors to eventually reach the state of a reliable, highly versatile, and widely applicable analytical tool suitable for use at the Point-of-Care.

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Section: Newest Developments In Optical Immunosensors: Bioanalytical ...mentioning

confidence: 99%

Recent Developments in the Field of Optical Immunosensors Focusing on a Label-Free, White Light Reflectance Spectroscopy-Based Immunosensing Platform

Karachaliou

Koukouvinos

Goustouridis

et al. 2022

Sensors

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show abstract

“…All of them are applied in different fields and help to delivery drugs. Some NPs are used to diagnose cancer, like MoS2 nanomaterials used as a platform material in bladder cancer diagnosis (71);NPs as biomarker in the diagnosis of early ovarian cancer (72).And some NPs are used to treat diseases, like NPs based on ROS even can be used in the treatment of myocardial ischemia reperfusion injury (73):NPs based on rheumatoid arthritis microenvironment can be a new direction for rheumatoid arthritis treatment (74). Different NPs based on different physical properties can be used in different ways.…”

Section: Overview Of Nanotechnology In Cancermentioning

confidence: 99%

Nanoparticle-Based Combination Therapy for Melanoma

Chen

Hou

et al. 2022

Front. Oncol.

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Melanoma is a cutaneous carcinoma, and its incidence is rapidly increasing with every year. The treatment options for melanoma have been comprehensively studied. Conventional treatment methods (e.g., radiotherapy, chemotherapy and photodynamic therapy) with surgical removal inevitably cause serious complications; moreover, resistance is common. Nanoparticles (NPs) combined with conventional methods are new and promising options to treat melanoma, and many combinations have been achieving good success. Due to their physical and biological features, NPs can help target intended melanoma cells more efficiently with less damage. This creates new hope for a better treatment strategy for melanoma with minimum damage and maximum efficacy.

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“…Second, the enhanced permeability and retention effect (EPR effect) ( Kanamala et al, 2016 ) in tumors allows nanodrugs to achieve high tumor selectivity. In addition, modifying the nanodrugs with functional groups that specifically recognize cancer cells or respond to the tumor microenvironment increases their selectivity ( Wang et al, 2021 ; Yang et al, 2022 ). Finally, nanodrugs have flexible physicochemical properties, and those with reasonable components and specific functional design can cleave lysosomes more efficiently than small molecule drugs, yielding more potent anticancer effects ( Ai et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Nanodrugs Detonate Lysosome Bombs

Xiang

Liu

et al. 2022

Front. Pharmacol.

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Cancer cell lysosomes contain various hydrolases and non-degraded substrates that are corrosive enough to destroy cancer cells. However, many traditional small molecule drugs targeting lysosomes have strong side effects because they cannot effectively differentiate between normal and cancer cells. Most lysosome-based research has focused on inducing mild lysosomal membrane permeabilization (LMP) to release anticancer drugs from lysosomal traps into the cancer cell cytoplasm. In fact, lysosomes are particularly powerful “bombs”. Achieving cancer cell-selective LMP induction may yield high-efficiency anticancer effects and extremely low side effects. Nanodrugs have diverse and combinable properties and can be specifically designed to selectively induce LMP in cancer cells by taking advantage of the differences between cancer cells and normal cells. Although nanodrugs-induced LMP has made great progress recently, related reviews remain rare. Herein, we first comprehensively summarize the advances in nanodrugs-induced LMP. Next, we describe the different nanodrugs-induced LMP strategies, namely nanoparticles aggregation-induced LMP, chemodynamic therapy (CDT)-induced LMP, and magnetic field-induced LMP. Finally, we analyze the prospect of nanodrugs-induced LMP and the challenges to overcome. We believe this review provides a unique perspective and inspiration for designing lysosome-targeting drugs.

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Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

Cited by 31 publications

References 144 publications

Recent Developments in the Field of Optical Immunosensors Focusing on a Label-Free, White Light Reflectance Spectroscopy-Based Immunosensing Platform

Recent Developments in the Field of Optical Immunosensors Focusing on a Label-Free, White Light Reflectance Spectroscopy-Based Immunosensing Platform

Nanoparticle-Based Combination Therapy for Melanoma

Nanodrugs Detonate Lysosome Bombs

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