Femtosecond laser treatment of 316L improves its surface nanoroughness and carbon content and promotes osseointegration: An in vitro evaluation

Kenar, Halime; Akman, Erhan; Kacar, E.; Demir, A.; Park, Hai-Woong; Abdul‐Khaliq, Hashim; Aktas, Cenk; Karaöz, Erdal

doi:10.1016/j.colsurfb.2013.02.039

Cited by 51 publications

(16 citation statements)

References 42 publications

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“…These studies generally correlate the improved osseointegration with superhydrophobic surface structures, which suggests that the wetting behaviour may be suitable to determine cell response on patterned surfaces [138]. While titanium is a popular material for biomedical implants, several other materials, such as stainless steel [139], titanium/niobium/zirconium alloys [140], nickel/titanium alloy [9], platinum [138], and silicon [141], have been investigated and shown to result in similarly beneficial properties for biocompatibility. Apart from osteoblasts and fibroblasts, selective proliferation of neurons was demonstrated on a silicon surface microstructured by a femtosecond laser [142].…”

Section: Applicationsmentioning

confidence: 90%

Fabrication of Micro/Nano Structures on Metals by Femtosecond Laser Micromachining

2014

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Abstract:Femtosecond laser micromachining has emerged in recent years as a new technique for micro/nano structure fabrication because of its applicability to virtually all kinds of materials in an easy one-step process that is scalable. In the past, much research on femtosecond laser micromachining was carried out to understand the complex ablation mechanism, whereas recent works are mostly concerned with the fabrication of surface structures because of their numerous possible applications. The state-of-the-art knowledge on the fabrication of these structures on metals with direct femtosecond laser micromachining is reviewed in this article. The effect of various parameters, such as fluence, number of pulses, laser beam polarization, wavelength, incident angle, scan velocity, number of scans, and environment, on the formation of different structures is discussed in detail wherever possible. Furthermore, a guideline for surface structures optimization is provided. The authors' experimental work on laser-inscribed regular pattern fabrication is presented to give a complete picture of micromachining processes. Finally, possible applications of laser-machined surface structures in different fields are briefly reviewed.

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Section: Applicationsmentioning

confidence: 90%

Fabrication of Micro/Nano Structures on Metals by Femtosecond Laser Micromachining

2014

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“…Several groups have studied the cell behavior in fs-structured surfaces and have obtained very promising results212223. Cunha et al 24.…”

mentioning

confidence: 99%

Surface micro- and nano-texturing of stainless steel by femtosecond laser for the control of cell migration

Martínez-Calderón

Manso‐Silván

Rodríguez

et al. 2016

Sci Rep

101

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The precise control over the interaction between cells and the surface of materials plays a crucial role in optimizing the integration of implanted biomaterials. In this regard, material surface with controlled topographic features at the micro- and nano-scales has been proved to affect the overall cell behavior and therefore the final osseointegration of implants. Within this context, femtosecond (fs) laser micro/nano machining technology was used in this work to modify the surface structure of stainless steel aiming at controlling cell adhesion and migration. The experimental results show that cells tend to attach and preferentially align to the laser-induced nanopatterns oriented in a specific direction. Accordingly, the laser-based fabrication method here described constitutes a simple, clean, and scalable technique which allows a precise control of the surface nano-patterning process and, subsequently, enables the control of cell adhesion, migration, and polarization. Moreover, since our surface-patterning approach does not involve any chemical treatments and is performed in a single step process, it could in principle be applied to most metallic materials.

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“…Cell adhesion and several cellular functions are strongly influenced by the surface properties of a material. It has been proved that surface chemistry, energy, topography and wettability are key factors that affect protein adsorption and blood coagulation, which may have an impact on the adhesion, migration and differentiation of osteogenic cells, playing an important role in implants' osteointegration [31,32]. In the studied cases, an increase in the protein adsorption and osteoblast differentiation parameters for laser-treated surfaces was observed, in spite of their lower wetting properties.…”

Section: Resultsmentioning

confidence: 86%

In Vitro Evaluation of Laser-Induced Periodic Surface Structures on New Zirconia/Tantalum Biocermet for Hard-Tissue Replacement

Jorge-Mora¹,

Imaz²,

Frutos³

et al. 2017

Laser Ablation - From Fundamentals to Applications

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This study investigates the biological response of zirconia/tantalum biocermet materials with laser-induced periodic surface structures (LIPSS) generated using a femtosecond laser working at 1030 nm wavelength. LIPSS were formed by laser radiation slightly above the applied threshold fluence. LIPSS features were characterized using techniques such as atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). LIPSS were generated in this study by applying femtosecond pulses with 500 fs pulse duration at a high-repetition rate to smooth-polished zirconia/tantalum biocermet surfaces, with an original roughness value of 3.8 AE 0.2 and 3.1 AE 0.2 nm, respectively. We have demonstrated in vitro that LIPSS are an efficient option to increase osteoblastic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) in ZrO 2 :Ta biocermets. LIPSS created increase cell metabolism statistically (best values in 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay) and decrease inflammatory response to the material (IL-6 and TNF-alpha values). Extracellular matrix production (ECM) is produced in more quantity and cells differentiate to osteoblast easily. These differences are seen from the beginning until the endpoint (day 20).

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Femtosecond laser treatment of 316L improves its surface nanoroughness and carbon content and promotes osseointegration: An in vitro evaluation

Cited by 51 publications

References 42 publications

Fabrication of Micro/Nano Structures on Metals by Femtosecond Laser Micromachining

Fabrication of Micro/Nano Structures on Metals by Femtosecond Laser Micromachining

Surface micro- and nano-texturing of stainless steel by femtosecond laser for the control of cell migration

In Vitro Evaluation of Laser-Induced Periodic Surface Structures on New Zirconia/Tantalum Biocermet for Hard-Tissue Replacement

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