Femtosecond-Laser-Induced Nanocavitation in Water: Implications for Optical Breakdown Threshold and Cell Surgery

Vogel, Alfred; Linz, Norbert; Freidank, Sebastian; Paltauf, Guenther

doi:10.1103/physrevlett.100.038102

Cited by 281 publications

(263 citation statements)

References 14 publications

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“…Relation (2.5) together with (2.4) allows for a precise determination of R max with just a hydrophone (Hentschel & Lauterborn 1982;Vogel et al 1986;Vogel & Lauterborn 1988;Venugopalan et al 2002;Hutson & Ma 2007), without the need for high-speed photography, through the determination of T osc from the shock waves emitted at generation (time t g ) and at collapse (time t c ). Alternatively, T osc can be determined by detecting the deflection of a probe laser beam (Vogel et al 2008). This method works even for very small bubbles, for which acoustic transients cannot be detected.…”

Section: B Han and Othersmentioning

confidence: 99%

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Dynamics of laser-induced bubble pairs

et al. 2015

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The interaction of two laser-induced bubbles in bulk water is investigated. The strength and direction of the emerging liquid jets can be controlled by adjusting the relative bubble positions, the time difference between bubble generation, and the laser pulse energies determining the bubble sizes. Experimental and numerical studies are performed for millimetre-sized bubble pairs. Taking bubbles of equal energy, a maximum jet velocity is found for close anti-phase bubbles, i.e. when the second bubble is produced at the maximum volume of the first one and the bubble walls are almost touching and not merging. Under these conditions, one bubble produces a fast jet with a peak velocity of about 150 m s −1 that reaches a distance into the surrounding liquid of at least three times the maximum bubble radius. Collapse of the other bubble results in a slow jet of large mass that rapidly converts into a ring vortex. Correspondingly, the interaction with adjacent structures is dominated either by localized jet impact or by shear stresses extending over a larger area. Furthermore, interactions between micrometre-sized bubble pairs are investigated numerically to understand and predict how the effects of the physical parameters on bubble dynamics would change when the bubbles become smaller. The results are discussed with respect to micropumping and opto-injection.

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Section: B Han and Othersmentioning

confidence: 99%

“…Surface tension, σ , produces a pressure 2σ /R scaling inversely proportional to the bubble radius, R, which adds to the hydrostatic pressure. A correction factor is presented by Vogel et al (2008). The relative initiation bubble distance, γ , is defined as…”

Section: B Han and Othersmentioning

confidence: 99%

Dynamics of laser-induced bubble pairs

et al. 2015

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“…When a near-infrared femtosecond laser is tightly focused in an aqueous solution under a microscope, shock and stress waves are generated at the laser focal point (4)(5)(6). These waves localize in a micrometer-sized space around the laser focal point (4) and they act as an impulsive force on a micrometer-sized object, such as a single cell, which is located near the laser focal point (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Time-Course Statistical Evaluation of Intercellular Adhesion Maturation by Femtosecond Laser Impulse

Iino

Hagiyama

Furuno

et al. 2016

Biophysical Journal

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The maturation of intercellular adhesion is an essential process for establishing the signal transduction network in living cells. Although the maturation is naturally considered to enhance the signal transduction, the relationship between the signal transduction and the maturation process has not been revealed in detail using time-course data. Here, using a coculture of mast cells and neurites, differences in maturation between individual cells were estimated as a function of the adhesion strength by our original single-cell measurement method utilizing a laser-induced impulsive force. When an intense femtosecond laser is focused into a culture medium under a microscope, shock and stress waves are generated at the laser focal point that exert an impulsive force on individual cells. In our method, this impulse is used to break the adhesion between a mast cell and a neurite. The magnitude of the impulse is then quantified by a local force-measurement system utilizing an atomic force microscope, and the adhesion strength is estimated from the threshold of the impulse required to break the adhesion. The measurement is conducted within 1 min/cell, and thus, data on the individual differences of the adhesion strength can be obtained within only a few hours. Coculturing of neurites and mast cells for 4 h resulted in a specific adhesion that was stronger than the nonspecific adhesions between the substrate and mast cells. In the time-course investigation, we identified two distinct temporal patterns of adhesion: 1) the strength at 24 h was the same as the initial strength; and 2) the strength increased threefold from baseline and became saturated within 24 h. Based on these results, the distribution of CADM1 adhesion molecules in the neurites was suggested to be inhomogeneous, and the relationship between adhesion maturation and the signal-transduction process was considered.

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“…This oscillation transfers the kinetic energy associated with the bubble to intense shear, shock wave emissions, adiabatic heating and evaporation of the liquid at the focal volume. Experimentally upon the observation of the cavitation bubble it is predicted that the optical breakdown has occurred 14,15 . From the theoretical point of view, optical breakdown is achieved only when the free electron density number reaches the critical density number ~10 21 cm -3 .…”

Section: Figure 2 (A) Fsrs Signals At Different Input Energies (B) mentioning

confidence: 99%

Onset of ice VII phase during ps laser pulse propagation through liquid water

Kumar¹,

Kiran²

2017

AIP Conference Proceedings

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The behavior of iron under ultrafast shock loading driven by a femtosecond laser AIP Conference Proceedings 1793, 100035 (2017) Abstract. Water dominantly present in liquid state on earth gets transformed to crystalline polymorphs under different dynamic loading conditions. Out of different crystalline phases discovered till date, ice VII is observed to be stable over wide pressure (2-63 GPa) and temperature (>273 K) ranges. The formation of ice VII crystalline structure has been vastly reported during high pressure static compression using diamond anvil cell and propagation of high energy (>50 mJ/pulse) nanosecond laser pulse induced dynamic high pressures through liquid water. We present the onset of ice VII phase at low threshold of 2 mJ/pulse during 30 ps (532 nm, 10 Hz) laser pulse induced shock propagating through liquid water.Role of input pulse energy on the evolution of Stoke's and anti-Stoke's Raman shift of the dominant A 1g mode of ice VII, filamentation, free-electrons, plasma shielding is presented. The H-bond network rearrangement, electron ion energy transfer time coinciding with the excitation pulse duration supported by the filamentation and plasma shielding of the ps laser pulses reduced the threshold of ice VII structure formation. Filamentation and the plasma shielding have shown the localized creation and sustenance of ice VII structure in liquid water over 3 mm length and 50 m area of cross-section.

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Femtosecond-Laser-Induced Nanocavitation in Water: Implications for Optical Breakdown Threshold and Cell Surgery

Cited by 281 publications

References 14 publications

Dynamics of laser-induced bubble pairs

Dynamics of laser-induced bubble pairs

Time-Course Statistical Evaluation of Intercellular Adhesion Maturation by Femtosecond Laser Impulse

Onset of ice VII phase during ps laser pulse propagation through liquid water

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