Femoral Neck Bone Mineral Density in Persons Over 50 Years Performing Shiftwork

Santhanam, Prasanna; Khthir, Rodhan; Dial, Larry; Driscoll, Henry K.; Gress, Todd

doi:10.1097/jom.0000000000000662

Cited by 12 publications

(3 citation statements)

References 12 publications

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“…These findings supported the correlation between sleep disturbance, circadian rhythm, and bone health. Studies have demonstrated that those who worked night shifts had lower bone density compared to those who worked day shifts [ 90 , 93 , 94 ]. It was speculated that the low bone density in night shift workers is due to an increase in cortisol and altered vitamin D status from sleep disturbances.…”

Section: Circadian Rhythm and Bone Healthmentioning

confidence: 99%

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

et al. 2023

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The circadian system in the human body responds to daily environmental changes to optimise behaviour according to the biological clock and also influences various physiological processes. The suprachiasmatic nuclei are located in the anterior hypothalamus of the brain, and they synchronise to the 24 h light/dark cycle. Human physiological functions are highly dependent on the regulation of the internal circadian clock. Skeletal muscles comprise the largest collection of peripheral clocks in the human body. Both central and peripheral clocks regulate the interaction between the musculoskeletal system and energy metabolism. The skeletal muscle circadian clock plays a vital role in lipid and glucose metabolism. The pathogenesis of osteoporosis is related to an alteration in the circadian rhythm. In the present review, we discuss the disturbance of the circadian rhythm and its resultant effect on the musculoskeletal system. We also discuss the nutritional strategies that are potentially effective in maintaining the system’s homeostasis. Active collaborations between nutritionists and physiologists in the field of chronobiological and chrononutrition will further clarify these interactions. This review may be necessary for successful interventions in reducing morbidity and mortality resulting from musculoskeletal disturbances.

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Section: Circadian Rhythm and Bone Healthmentioning

confidence: 99%

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

et al. 2023

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“…However, results from epidemiological human studies on the association between night shift work and BMD have been mixed. Two studies identified lower BMD in night shift workers [36,37] whereas two others found no difference in BMD according to shift worked [38,39 ▪▪ ]. Although human studies on the association between night shift work and BMD are mixed and human intervention studies have not been long enough to evaluate changes in BMD or bone microarchitecture, insight was gained from a study by Lucassen et al [40] in mice.…”

Section: Night Shift Work and Bone Healthmentioning

confidence: 99%

Sleep disruptions and bone health: what do we know so far?

Swanson¹

2021

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review This review briefly summarizes the growing body of literature addressing the skeletal consequences of sleep and circadian disruption. Recent findings The most recent data in the field suggest that the diurnal variation in bone turnover markers are because of endogenous circadian rhythmicity linked to clock genes in all bone cells; in a small human intervention study, cumulative sleep restriction with concurrent circadian disruption negatively alter bone turnover markers in a way that could explain the lower BMD and increased fracture risk identified in some prior night shift work studies; abnormal sleep duration and obstructive sleep apnea are associated with low BMD and increased fracture risk in some but not all studies. Summary Normal physiology and some animal and human intervention studies suggest that sleep and circadian disruptions, such as night shift work, abnormal sleep durations and obstructive sleep apnea are detrimental to skeletal health. However, additional research in this area is needed to determine which sleep/circadian disturbances are most detrimental to skeletal health, the reversibility of such impairments, and underlying mechanisms.

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“…A subsequent larger (N = 3,005) study of young (average age 36.4 years) Korean men and women also found lower BMD at the lumbar spine and total hip in people who worked shifts outside daytime hours, particularly in those who worked the night shift [63]. Conversely, there was no difference in BMD in middle-aged male and female shift workers (N = 225) in the NHANES cohort compared to regular workers (N = 738) [64].…”

Section: 0 Associations Among Shift Work the Associated Sleep/circmentioning

confidence: 99%

The importance of the circadian system & sleep for bone health

et al. 2018

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Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

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Femoral Neck Bone Mineral Density in Persons Over 50 Years Performing Shiftwork

Abstract: Shiftwork does not seem to affect bone mineral density in those performing moderate physical activity.

Cited by 12 publications

References 12 publications

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

Sleep disruptions and bone health: what do we know so far?

The importance of the circadian system & sleep for bone health

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