“…Although polymethylmethacrylate (PMMA) bone cement is biocompatible, adverse cardiopulmonary effects 57 58 59 60 61 62 have been widely documented during and after the cementation period. Modern cement techniques, 63 including pressurisation, which were developed to improve cement penetration and fixation can exacerbate these events. 64 During the reaming and pressurisation processes fat, marrow, air, particles of bone, cement, and aggregates of platelets and fibrin are driven into the systemic circulation 57 with the potential for intraoperative and postoperative embolic events and adult respiratory distress syndrome.…”