Femoral artery flow and pain during lumbar aortography: Comparison of ionic and non-ionic contrast media

Padayachee, T.S.; Reidy, John F.; King, D. H.; Reeves, Michael A.; Gosling, R. G.

doi:10.1016/s0009-9260(83)80389-4

Cited by 20 publications

(11 citation statements)

References 13 publications

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“…The effects of iodixanol are qualitatively similar to the other non-ionic LOCM, but the magnitude of the change in femoral arterial blood flow appears to be less pronounced. Several studies have shown a correlation between increased femoral arterial blood flow and osmolality of the CM, but factors other than hyper-osmolality also contribute to the effect of CM on the vascular resistance, like viscosity, pH and chemotoxicity (2,12,13).…”

Section: Discussionmentioning

confidence: 99%

Pain in femoral arteriography: A double-blind, randomized, clinical study comparing safety and efficacy of the iso-osmolar iodixanol 270mgI/ml and the low-osmolar iomeprol 300 mgI/ml in 9 European centers

et al. 2003

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Section: Discussionmentioning

confidence: 99%

Pain in femoral arteriography: A double-blind, randomized, clinical study comparing safety and efficacy of the iso-osmolar iodixanol 270mgI/ml and the low-osmolar iomeprol 300 mgI/ml in 9 European centers

et al. 2003

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“…A decrease in osmolality within this range will occur if a ratio 1.5 contrast medium with an osmolality of 1.5-2.0 mol/kg is diluted by adding 10 volume per cent of an anesthetic solution almost isotonic to blood. Therefore the results of several of the reviewed investigations (15,16,21,28,30,38) may be influenced by an unfair comparison between an undiluted and a diluted contrast medium.…”

Section: Discussionmentioning

confidence: 99%

“…According to several reports ratio 3 contrast media induce less pain and heat during angiography than ratio 1.5 compounds without local anesthetics (3, 12, 13, 17, 22, 25, 27-29, 38, 41). Five of the seven reviewed investigations in Table 4 (17,19,32,36,38) showed that ratio 3 contrast media also induce less pain and discomfort than ratio 1.5 media diluted with local anesthetics, while two investigations showed no difference (28,31). These two investigations were not completely performed in an intra-individually randomized and double-blind fashion.…”

Section: Rate Of Least Discomforting Injection Contrast Solutionmentioning

confidence: 99%

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Addition of Local Anesthetics to Contrast Media

Nilsson¹,

Almén²,

Golman³

et al. 1987

Acta Radiol

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Effects of equiosmolar solutions (osmolality 1.35 mol/kg) of the ratio 1.5 contrast medium metrizoate (250 mg l/ml) containing either the local anesthetic mepivacaine or saline were evaluated on subjective discomfort, aortic blood pressure and heart rate in 17patients referred for aortofemoral angiography due to intermittent claudication. Each patient was injected with 30 ml (15 mils) of each solution in random double-blind order. Each patient was then injected with 45 ml (12 ml/s) of the ratio 3 medium ioxaglate (320mg l/ml, osmolality 0.58 mIlkg). loxaglate caused significantly less total discomfort, pain, heat, vocal reactions, involuntary movements and hemodynamic effects than metrizoate-mepivacaine and metrizoate-saline. The effects of the two metrizoate solutions did not differ significantly. Previous contradictory reports on the effects of anesthetics in contrast media were reviewed with regard to experimental design, different osmolality of the test and control solutions, premedication, and pH dependence of local anesthetics. Ratio 3 media are recommended because they produce a more reliable relief of patient discomfort and fewer hemodynamic changes than the addition of loc'al anesthetics to ratio 1.5 media.

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“…ratio 3 compounds such as the non-ionic monomeric iopamidol and iohexol or the ionic dimeric ioxaglate. They produce significantly less pain than the ratio 1.5 media at peripheral angiography (3, 6, 13, 17, 22, 25, 27-29, 37, 38, 43) and significantly less hemodynamic changes due to a smaller vasodilatory effect (3,20,22,27,28,35,42).…”

mentioning

confidence: 94%