Female infertility and herbal medicine: An overview of the new findings

Akbaribazm, Mohsen; Goodarzi, Nader; Rahimi, Mitra

doi:10.1002/fsn3.2523

Cited by 42 publications

(26 citation statements)

References 113 publications

(115 reference statements)

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“…CHM can increase the reproductive capacity of infertile patients in various ways, whose efficacy and safety in treatment have attracted growing attention and recognition [ 24 , 25 ]. A Korean researcher pointed out that a growing number of infertile couples would choose CHM to treat infertility [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Recently, with the development of the social economy, the incidence of infertility has increased year by year. With its complex etiology and diversified syndromes, infertility has become one of the most important diseases that plague the physical and mental health of women of childbearing age worldwide. Endometrial factors as an important part affecting female reproductive capacity, due to which induced repeated abortion and multiple uterine cavity operations occur, can destruct endometrium, failing to provide a normal implantation environment for zygote, thus resulting in infertility. Many patients failed to achieve expected results after receiving conventional treatments such as hormone therapy, assisted reproductive technology (ART), granulocyte colony-stimulating factor (G-CSF) therapy, and cell therapy, then turn to complementary and alternative medicine (CAM) therapies for help. Aiming at clarifying the effectiveness and mechanisms of CAM therapy in the treatment of infertility caused by endometrial factors, our paper systematically searched and studied present related literature on the PubMed, CNKI, and other databases, focusing on the aspects of clinical application and mechanism explorations and highlighting the therapeutic effects of Chinese herbal medicine (CHM), acupuncture, and moxibustion on such diseases. Moreover, this paper also introduces the CAM treatments of traditional Chinese medicine (TCM) retention enema, neuromuscular electrical stimulation (NMES), photobiomodulation therapy, dietary intervention, and other measures for infertility caused by endometrial factors, in order to provide a reference for subsequent basic research and clinical work.

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Section: Methodsmentioning

confidence: 99%

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The positive effects of antioxidants in female fertility have also been described [ 346 , 347 , 348 , 349 ]. OS has also been recognised as one of the main mediators of female infertility and has been associated with various reproductive pathologies, including endometriosis, preeclampsia, spontaneous abortion, and unexplained infertility [ 347 , 348 ].…”

Section: Health Effectsmentioning

confidence: 99%

“…Research on the polyphenols, flavonoids, and vitamins of tomatoes, including vitamin E, quercetin, and naringenin, indicates that these compounds may also play important roles in the enhancement of semen quality, including sperm concentration, motility, vitality, and structural integrity [ 139 , 341 , 342 , 345 , 349 , 351 , 357 ]. Although other findings are conflicting, according to Aitken et al, at high doses quercetin can have adverse effects on spermatozoa [ 341 , 358 ].…”

Section: Health Effectsmentioning

confidence: 99%

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

Collins

Bowyer

Tsouza

et al. 2022

Biology

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This review outlines the health benefits associated with the regular consumption of tomatoes and tomato products. The first section provides a detailed account of the horticultural techniques that can impact the quality of the fruit and its nutritional properties, including water availability, light intensity, temperature, and growing media. The next section provides information on the components of tomato that are likely to contribute to its health effects. The review then details some of the health benefits associated with tomato consumption, including anticancer properties, cardiovascular and neurodegenerative diseases and skin health. This review also discusses the impact tomatoes can have on the gut microbiome and associated health benefits, including reducing the risk of inflammatory bowel diseases. Other health benefits of eating tomatoes are also discussed in relation to effects on diabetes, the immune response, exercise recovery, and fertility. Finally, this review also addresses the negative effects that can occur as a result of overconsumption of tomato products and lycopene supplements.

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“…In addition, a nonpharmacological intervention with flavonoids should be considered in women suffering from PCOS because of their large anti-inflammatory and antioxidant activities [ 142 ]. In murine models, flavonoids extracted from Nervilia Fordii are able to positively balance FSH, LH, testosterone and insulin levels, preventing JAK2/STAT3 pathway activation and upregulating IL-6 expression [ 143 ].…”

Section: Dietary Modificationmentioning

confidence: 99%

Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome

et al. 2022

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Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder mainly characterized by a hormonal and metabolic disbalance that leads to oligo/anovulation, hyperandrogenism and the formation of ovarian cysts. Despite the progress that has been reached in its diagnosis and management, little is known about the molecular mechanisms and signaling pathways underlying the pathogenic mechanisms. In this sense, recent research has suggested that the influence of multiple factors, including age, environment, lifestyle and the disease state environment can change the clinical presentation of PCOS via epigenetic modifications. Variants in the genes encoding for proteins involved in steroidogenesis and glucose homeostasis play a crucial role in the development of the disease. Other genes involved in inflammation and cell proliferation seem to undergo an epigenetic control. Moreover, lifestyle factors influence the PCOS course and prognosis, including diet and physical activity, which are fundamental in reducing oxidative stress, inflammation and in improving metabolic and hormonal parameters. In the present review, literature evidence on molecular and epigenetic mechanisms related to PCOS etiology will be discussed, with a particular attention on the positive influence of diet and physical activity as nonpharmacological ways of intervention in the management of the disease.

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Female infertility and herbal medicine: An overview of the new findings

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 42 publications

References 113 publications

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome

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