Female gender as a determinant of cough threshold to inhaled capsaicin

Fujimura, Masaki; Kondo, Kazuo; Kamio, Yumie; Naruse, Masaharu; Hashimoto, Takuma; Matsuda, Tamotsu

doi:10.1183/09031936.96.09081624

Cited by 157 publications

(132 citation statements)

References 19 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…WAGNER et al [28] also showed a strong correlation between increase in peripheral resistance and degree of bronchial hyperresponsiveness to methacholine. Interestingly, studies have shown a higher smoke-related bronchial hyperresponsiveness in females compared with males [3] and lower cough threshold in females than males when they were exposed to cough stimuli (capsaicin) [29]. Further measurements of bronchial hyperresponsiveness in population-based studies might clarify this.…”

Section: Tobacco Smoking and Respiratory Symptomsmentioning

confidence: 98%

Sex differences in lung vulnerability to tobacco smoking

Johnsen¹,

Gulsvik²,

Holmen³

et al. 2003

Eur Respir J

123

View full text Add to dashboard Cite

Studies have indicated that females are more vulnerable to the deleterious effect of tobacco smoking than males. The current study aimed to investigate the associations between tobacco smoking and reported respiratory symptoms, self-rated health, and lung function by sex.In 1995-1997 65,225 subjects aged o20 yrs (71% of invited) attended for screening within the Nord-Trøndelag Health Study. Among these, 10,941 subjects selected randomly or because they reported having asthma or asthma-related symptoms, participated in the Bronchial Obstruction in Nord-Trøndelag study consisting of spirometry and a personal interview.Tobacco smoking was associated with increased prevalence of respiratory symptoms, reduced lung function, and lower score on global self-rated health (SRH). Adjusted for smoking burden and lung function, females had a higher risk for reporting respiratory symptoms and lower SRH compared with males. Further, smoking burden was associated with a larger relative reduction in expiratory lung function in females than in males.Females reported more symptoms and lower self-rated health compared with males with similar smoking burden. Even if smoking in females was associated with a larger reduction in per cent predicted lung function compared with males, this does not fully explain the higher symptom prevalence in females.

show abstract

Section: Tobacco Smoking and Respiratory Symptomsmentioning

confidence: 98%

Sex differences in lung vulnerability to tobacco smoking

Johnsen¹,

Gulsvik²,

Holmen³

et al. 2003

Eur Respir J

123

View full text Add to dashboard Cite

show abstract

“…With this technique, capsaicin concentrations (or other tussives such as citric acid and distilled water) are doubled until two and five "cough events" (typically defined by the number of expulsive events, or "cough sounds") are achieved, representing the threshold and suprathreshold response, respectively. These studies have shown differences in the cough response between ages [13], genders [14][15][16] and diseases [4,5,13,17]. However, these data cannot infer changes in expiratory muscle activation, duration of expulsive phases and the airflow dynamics with increasing capsaicin concentration, all which are essential components in defining the cough response.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner

Vovk

Bolser

Hey³

et al. 2007

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

The airway defensive response to tussive agents, such as capsaicin, is frequently assessed by counting the number of cough sounds, or expulsive events. This method does not identify or differentiate important respiratory events that occur in the respiratory muscles and lungs, which are critical in assessing airway defensive responses. The purpose of this study was to characterize the airway defensive behaviours (cough and expiration reflex) to capsaicin exposure in humans. We observed complex motor behaviours in response to capsaicin exposure. These behaviours were defined as cough reacceleration (CRn) and expiration reflex (ERn), where n is the number of expulsive events with and without a preceding inspiratory phase, respectively. Airway defensive responses were defined in terms of frequency (number of expulsive events), strength (activation of abdominal muscles) and behaviour type (CRn vs. ERn). Thirty-six subjects (15 females, 24±4 yr) were instrumented with EMG electrodes placed over the rectus abdominis (RA), external abdominal oblique (EO) and the 8th intercostal space (IC8). A custom-designed mouth pneumotachograph was used to assess the airflow acceleration, plateau velocity and phase duration of the expulsive phase. Subjects inhaled seven concentrations of capsaicin (5-200 μM) in a randomized block order. The total number of expulsive events (frequency) and the sum of integrated EMG for the IC8, RA and EO (strength) increased in a curvilinear fashion. Differentiating the airway defense responses into type demonstrated predominately CR1 and CR2 (i.e. inspiration followed by one and two expulsive events, respectively) with very few ER's at <50 μM capsaicin. At higher concentrations (>50 μM) ER's with one or more expulsive events (≥ER1) appeared, and the number of CR's with three or more expulsive events (≥CR3) increased. The decrease in EMG activation and airflow measurements with each successive expulsive event suggests a decline in power and shear force as the number of expulsive events increased. Therefore, the airway defensive response to capsaicin is a complex motor pattern that functions to coordinate ER's and CR's with differing numbers of expulsive events possibly to prevent aspirations and keep air moving to promote clearance.

show abstract

“…Healthy women have a more sensitive cough reflex than do healthy men [8,9], and women with chronic cough demonstrate an enhanced cough reflex compared with their male counterparts [10]. In terms of health-related quality of life, women are significantly more adversely affected by chronic cough than are men [11].…”

mentioning

confidence: 99%

Thoughts on One Thousand Chronic Cough Patients

Dicpinigaitis

2012

Lung

View full text Add to dashboard Cite

Cough is the most common complaint for which patients seek medical attention. Although most cases of acute cough, due to viral upper respiratory tract infection, are transient and self-limited, chronic cough often poses a diagnostic and therapeutic challenge. A subgroup of patients suffering from chronic cough will elude a diagnosis despite appropriate evaluation, and will prove refractory to all therapeutic intervention. Having personally evaluated 1000 individuals presenting to a specialty cough center, the author shares insights regarding the demographic composition of this unique group of patients, as well as clinical observations and opinions on currently unmet needs requiring further research.

show abstract

Female gender as a determinant of cough threshold to inhaled capsaicin

Cited by 157 publications

References 19 publications

Sex differences in lung vulnerability to tobacco smoking

Sex differences in lung vulnerability to tobacco smoking

Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner

Thoughts on One Thousand Chronic Cough Patients

Contact Info

Product

Resources

About