Female age affects the utility of sperm DNA fragmentation in predicting IVF and ICSI outcomes

Liang, Xiaolei; Mao, Yifang; Wang, Yiqing; Liu, Shan; Yan, Jiexi

doi:10.1016/j.rbmo.2019.09.013

Cited by 17 publications

(13 citation statements)

References 37 publications

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“…Our findings are comparable with previous studies. We found that females who achieved pregnancy were younger and these results are similar to the results of Liang et al (21), who reported that female age is a predictor for successful pregnancy after IVF. In 2018 Pacey et al (22) concluded, after reviewing nine meta-analyses that evaluated DFI and pregnancy, that there remains little consensus about the use of DFI and whether it adds clinical value.…”

Section: Characteristicsupporting

confidence: 91%

Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection

et al. 2020

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Objective: To evaluate the ability of sperm DNA fragmentation index (DFI) and high DNA stainability (HDS) to influence the chance of achieving pregnancy in couples undergoing intracytoplasmic sperm injection (ICSI) cycles. Design: A retrospective study evaluating couples who underwent an ICSI cycle between 2009 and 2018. Setting: Reproductive center. Patient(s): Consecutive couples who underwent an ICSI cycle and had a semen analysis with subsequent DFI and HDS testing, evaluated using Sperm Chromatin Structure Assay. Intervention(s): Measurement of DFI and HDS prior to ICSI cycle. Main Outcome Measure(s): To determine whether DFI or HDS of sperm was predictive of the number of ICSI cycles until the first clinical intrauterine pregnancy. Result(s): A total of 550 couples who underwent 1,050 ICSI cycles were analyzed. Of those, a total of 330 couples achieved pregnancy.As expected, in couples who achieved pregnancy, females were younger and underwent fewer cycles. Importantly, the DFI and HDS were similar between couples who achieved pregnancy (DFI% 12.9; HDS% 9.3) and couples who did not (DFI% 12.2; HDS% 9.1). A multivariable-adjusted analysis evaluating female age at the first cycle was associated negatively with pregnancy. Conclusion(s):Neither DFI nor HDS at baseline influenced the chances of a couple to achieve pregnancy after ICSI. Increased female age and couples who underwent more ICSI cycles were associated with lower chances of achieving pregnancy. (Fertil Steril Rep Ò 2020;1: 233-8. Ó2020 by American Society for Reproductive Medicine.

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Section: Characteristicsupporting

confidence: 91%

Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection

et al. 2020

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“… 29 Similarly, the study by Liang et al revealed that when female age was older than 30 years, women with DFI >30% had lower clinical pregnancy rates and fewer good-quality embryos than women with DFI ≤30%. 41 In our study, the multivariate analysis indicated that female age and female abnormal BMI increased the risk of EPL in IVF cycles by 5.87 times (p=0.005) and 4.18 times (p=0.004), respectively.…”

Section: Discussionsupporting

confidence: 50%

Predictive Significance of Sperm DNA Fragmentation Testing in Early Pregnancy Loss in Infertile Couples Undergoing Intracytoplasmic Sperm Injection

Lê

Nguyen

et al. 2021

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Objective This study aimed to determine the role of sperm DNA fragmentation as a marker that could predict early pregnancy loss (EPL), either independently or in combination with another marker or markers, after intracytoplasmic sperm injection (ICSI) cycles. Methods This prospective descriptive cohort study retrieved data from 162 couples who underwent their first ICSI cycles at the Center for Reproductive Endocrinology and Infertility of Hue University Hospital in Vietnam from May 2018 to December 2019. General characteristics, semen parameters, sperm DNA fragmentation index (DFI), fertilization, embryo development, pregnancy rates, and EPL were assessed. The receiver-operating characteristic (ROC) method was performed to identify the threshold of DFI in EPL. Multivariate analysis was used to demonstrate the relationship between the sperm DNA fragmentation level and EPL. Results Of 162 ICSI cycles, 23 (14.2%) involved EPL. There was no significant difference between the sperm DNA fragmentation rate and the overall rate of pregnancy loss, although the negative pregnancy outcome group had a median DFI that was higher than that of the positive pregnancy outcome group (20% vs 17.8%). The ROC analysis indicated that a sperm DNA fragmentation rate of 16.6% was the priority cut-off that could be used to distinguish EPL with a sensitivity of 73.9% (95% confidence interval [CI], 67.15–80.67) and specificity of 47.48% (95% CI, 39.79–55.17). The multivariate analysis confirmed that in female factors such as age, body mass index (BMI), and sperm DNA fragmentation level affected the EPL rate. However, a combination of the sperm DNA fragmentation level and female age or female BMI could not sufficiently predict EPL. Conclusion EPL can be affected by multiple factors including sperm DNA fragmentation; however, there is no sufficient evidence indicating that sperm DNA fragmentation, both as a single marker and combined with other markers, is a good predictor of EPL.

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“…sensitivity and specificity, positive and negative predictive value;Zini & Sigman, 2009). The predictive power of SDF tests is influenced by type (SS-DB or DS-DB), site (intron or exons) and amount of damage in each cell, as well as the number of affected cells and the oocyte′s ability to repair SDF after fertilisation(Esteves, 2020;Jin et al, 2015;Liang et al, 2019;Sakkas & Alvarez, 2010). It seems plausible that different assays might be complementing each other in different clinical settings.…”

mentioning

confidence: 99%

Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

et al. 2020

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Female age affects the utility of sperm DNA fragmentation in predicting IVF and ICSI outcomes

Cited by 17 publications

References 37 publications

Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection

Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection

Predictive Significance of Sperm DNA Fragmentation Testing in Early Pregnancy Loss in Infertile Couples Undergoing Intracytoplasmic Sperm Injection

Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

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