Felis catus papillomavirus types 1 and 4 are rarely present in neoplastic and inflammatory oral lesions of cats

Munday, John S.; French, Adrienne F.

doi:10.1016/j.rvsc.2015.03.002

Cited by 30 publications

(44 citation statements)

References 11 publications

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“…FcaPV was only detected in 1 of 20 FOSCC samples. These results are consistent with all published literature that includes > 1 FOSCC patient, where PV infection was detected in only 0-6.9% of patients (Munday and French, 2015;Munday et al, 2019Munday et al, , 2009Munday et al, 2011b;O'Neill et al, 2011;Supsavhad et al, 2016;Yamashita-Kawanishi et al, 2018). It is possible that PV was not detected but causes FOSCC via a 'hit and run' mechanism, where E6 and E7 contribute to tumor initiation, the virus is lost in overt neoplasms, and it is not required to maintain the transformed phenotype.…”

Section: Discussionsupporting

confidence: 92%

“…None of the PV-positive FOSCC lesions from previous studies were classified as oropharyngeal ( Supplementary Table 2). To the author's knowledge PV status of oropharyngeal FOSCC has been evaluated in only 15 cats to date (Munday and French, 2015;Munday et al, 2019Munday et al, , 2009Munday et al, 2011b;O'Neill et al, 2011). Tonsillar FOSCC lesions have been associated with a better prognosis, than FOSCC lesions located in the oral cavity, when treated with an accelerated radiation therapy and carboplatin protocol (Fidel et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Chu

Wylie

et al. 2020

Veterinary Microbiology

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Feline oral squamous cell carcinoma (FOSCC) may be the best naturally-occurring model of human head and neck squamous cell carcinoma (HNSCC). HNSCC can be broadly divided into human papillomavirus (HPV)negative cancers and HPV-positive cancers where HPV is the causative agent. Previous studies in FOSCC have used both species-specific and species-nonspecific PCR primers that may be insensitive to the detection of PVs and other viruses that may be divergent from known sequences. ViroCap is a targeted capture and next generation sequencing tool that was designed to identify all known vertebrate DNA and RNA viruses. In this study we used a metagenomic approach using ViroCap for DNA viruses in 20 FOSCC, 9 normal feline oral mucosal, and 8 suspected PV positive control samples. We tested the hypothesis that viruses would be enriched in FOSCC compared to normal oral mucosa. The virome of the FOSCC and normal feline oral mucosa consisted of feline foamy virus in 7/20 and 2/9 (35% and 22%), feline torque teno virus in 2/20 and 0/9 (10% and 0%), alphaherpesvirus in 2/10 and 0/9 (10% and 0%), FIV (0% and 22%), Epstein-Barr virus in 1/20 and 0/9 (5% and 0%) and feline papillomavirus in 1/20 and 0/9 samples (5% and 0% respectively). Felis catus papillomavirus-3 was found in 1 of 20 FOSCC samples. A virus was not associated consistently with FOSCC. If PVs have a role in FOSCC it is at most a supplementary or uncommon role. FOSCC appears most closely related to HPV-negative HNSCC. Future research on FOSCC should focus on identifying genetic and environmental causes. (S. Chu). Veterinary Microbiology 240 (2020) 108491 0378-1135/ Published by Elsevier B.V.T

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Chu

Wylie

et al. 2020

Veterinary Microbiology

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“…On the other hand, we did not detect FcaPV‐1 DNA in any blood sample. Actually, FcaPV‐1 has been reported in limited geographical areas and appears to be very rare (Munday & French, ; Tachezy et al., ). This might explain, at least in part, our results, suggesting a low prevalence of these viral type in the geographical region analysed here.…”

Section: Discussionmentioning

confidence: 99%

“…DNA samples (100–150 ng) were subjected to PCR for detection of FcaPV‐1 and FcaPV‐2 DNA using the AmpliTaq Gold DNA Polymerase kit (Applied Biosystems, Waltham, Massachusetts, USA). To this aim, FPV‐1F/R and JMPF/R primers were selected as the most validated in the literature and employed to amplify a fragment of FcaPV‐1 E1 (175 bp) and FcaPV‐2 L1 genes (177 bp), respectively (Munday & French, ; Munday, Kiupel, French, & Howe, ). PCR was conducted under the following conditions: 95°C for 5 min (denaturation) followed by 40 amplification cycles of 95°C for 30 s (denaturation), 50°C for 30 s (annealing) and 72°C for 30 s (extension).…”

Section: Methodsmentioning

confidence: 99%

“…FcaPV-1 was first isolated from cutaneous viral plaques (VP) and papillomas, but later an association with feline oral papillomas was reported (Munday, Fairley, Mills, Kiupel, & Vaatstra, 2015;Tachezy et al, 2002). A few reports suggest an association of FcaPV-3 with Bowenoid in situ carcinoma (BISC) and FcaPV-5 with atypical VP, while FcaPV-4 has been found in the oral cavity but not in any neoplastic lesion so far (Munday, Fairley, & Atkinson, 2016;Munday & French, 2015;Munday et al, 2017). Thus, the potential role of FcaPV-1, FcaPV-3, FcaPV-4 and FcaPV-5 in the development of feline cancer is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

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Felis catus papillomavirus type-2 but not type-1 is detectable and transcriptionally active in the blood of healthy cats

Altamura

Jebara

Cardeti

et al. 2017

Transbound Emerg Dis

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Papillomaviruses (PVs) are small DNA viruses that induce benign and/or malignant epithelial tumours in different species, including the domestic cat (Felis catus). To date, five F. catus papillomavirus genotypes have been identified (FcaPV-1 to FcaPV-5). FcaPV-1 is associated with skin and oral benign lesions, while FcaPV-2 infection is widely associated with feline squamous cell carcinomas. Several human and animal PVs have been found in body fluids such as peripheral blood; however, the presence of FcaPVs in non-epithelial tissues has not previously been investigated. The aim of this study was to assess the presence and gene expression of FcaPV-1 and FcaPV-2 in the blood of healthy cats. We detected FcaPV-2 DNA in 26 of 103 (25%) blood samples. Importantly, FcaPV-2 L1, E2, E6 and E7 genes were found to be expressed in 3 (25%), 11 (92%), 6 (50%) and 5 (42%) of the samples available for mRNA analysis, respectively. FcaPV-1 was not detected in any of the blood samples analysed here. The data obtained in this work suggest active and eventually productive infection of FcaPV-2 in the blood of healthy cats, implying a possible role in intra-individual spreading as well as in vertical and horizontal transmission.

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Alimentary Tumors

Breithaupt¹

2016

Veterinary Oncology

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Felis catus papillomavirus types 1 and 4 are rarely present in neoplastic and inflammatory oral lesions of cats

Cited by 30 publications

References 11 publications

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Felis catus papillomavirus type-2 but not type-1 is detectable and transcriptionally active in the blood of healthy cats

Alimentary Tumors

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