A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Chu, Shirley; Wylie, Todd; Wylie, Kristine M.; Johnson, Gayle C.; Skidmore, Zachary L.; Fleer, Maren; Griffith, Obi L.; Bryan, Jeffrey N.

doi:10.1016/j.vetmic.2019.108491

Cited by 27 publications

(38 citation statements)

References 38 publications

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“…Due to genetic and behavioral similarities between FcaPV3 and the canine PVs, this PV was classified as the first member of the species 3 Taupapillomaviruses [ 52 ]. This PV has subsequently been detected within hyperplastic and neoplastic skin and oral lesions in cats, suggesting the PV can alter cell regulation [ 53 , 54 , 55 ]. Additionally, lesions that contained FcaPV3 DNA had marked p16 immunostaining suggesting that the virus can degrade pRb [ 53 ].…”

Section: Papillomaviruses That Infect Domestic Catsmentioning

confidence: 99%

Papillomaviruses in Domestic Cats

Munday

2021

Viruses

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Papillomaviruses (PVs) are well established to cause hyperplastic papillomas (warts) in humans and animals. In addition, due to their ability to alter cell regulation, PVs are also recognized to cause approximately 5% of human cancers and these viruses have been associated with neoplasia in a number of animal species. In contrast to other domestic species, cats have traditionally been thought to less frequently develop disease due to PV infection. However, in the last 15 years, the number of viruses and the different lesions associated with PVs in cats have greatly expanded. In this review, the PV life cycle and the subsequent immune response is briefly discussed along with methods used to investigate a PV etiology of a lesion. The seven PV types that are currently known to infect cats are reviewed. The lesions that have been associated with PV infections in cats are then discussed and the review finishes with a brief discussion on the use of vaccines to prevent PV-induced disease in domestic cats.

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Section: Papillomaviruses That Infect Domestic Catsmentioning

confidence: 99%

Papillomaviruses in Domestic Cats

Munday

2021

Viruses

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“…Even if previous lines of evidence have hypothesized a role of viruses in canine lymphoma ( 56 ), we could not confirm this hypothesis. However, similarly to feline species ( 57 ), studies dedicated to identify viral integration sites in canine cancers are needed, and transmissible venereal tumor and squamous carcinoma represent excellent models to further test VirusFinder2.…”

Section: Discussionmentioning

confidence: 99%

A First NGS Investigation Suggests No Association Between Viruses and Canine Cancers

Giannuzzi

Aresu

2020

Front. Vet. Sci.

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Approximately 10-15% of worldwide human cancers are attributable to viral infection. When operating as carcinogenic elements, viruses may act with various mechanisms, but the most important is represented by viral integration into the host genome, causing chromosome instability, genomic mutations, and aberrations. In canine species, few reports have described an association between viral integration and canine cancers, but more comprehensive studies are needed. The advancement of next-generation sequencing and the cost reduction have resulted in a progressive increasing of sequencing data in veterinary oncology offering an opportunity to study virome in canine cancers. In this study, we have performed viral detection and integration analyses using VirusFinder2 software tool on available whole-genome and whole-exome sequencing data of different canine cancers. Several viral sequences were detected in lymphomas, hemangiosarcomas, melanomas, and osteosarcomas, but no reliable integration sites were identified. Even if with some limitations such as the depth and type of sequencing, a restricted number of available nonhuman genomes software, and a limited knowledge on endogenous retroviruses in the canine genome, results are compelling. However, further experiments are needed, and similarly to feline species, dedicated analysis tools for the identification of viral integration sites in canine cancers are required.

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“…Over the years, these initial observations were reinforced by multiple reports from different groups and oral infection with high-risk HPV, especially HPV16, was consistently associated with increased HNSCC risk (27)(28)(29). Studies on bovine (30), canine (31), feline (32) and murine (33) models showed the ability of papillomaviruses to infect and induce different types of lesions in the oral cavity, as previously reviewed (34)(35)(36). More recently, our group demonstrated the ability of HPV16 to specifically induce tongue base HNSCC in transgenic mice (37), providing experimental evidence to support the etiologic role of HPV16 in this type of cancer.…”

Section: Hpv-positive Versus Hpv-negative Hnsccmentioning

confidence: 98%

Is There a Role for Sex Hormone Receptors in Head-and-neck Cancer? Links with HPV Infection and Prognosis

et al. 2021

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Background/Aim: Head-and-neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in the world and human papillomavirus (HPV) is an important risk factor for this neoplasm. Recent studies showed an association between sex hormone receptors and pathogenesis and/or prognosis in patients with HNSCC. The aim of this study was to clarify the expression patterns of sex hormone receptors in HPV-positive and HPV-negative HNSCC and their associations with tumour biopathology and biological behaviour. Materials and Methods: Scientific literature indexed in PubMed about sex hormone receptors in HNSCC was retrieved and critically analyzed, to obtain an overview of expression patterns and their possible implications for tumour biopathology and prognosis. Results: Sex hormone receptors were more frequently detected in oropharyngeal tumours compared with HNSCC from other locations. ERα was associated with HPV-positive tumours. The androgen and progesterone receptors were associated with poor patient prognosis. Estrogen receptor alpha (ERα) is implicated in the biopathology of HNSCC in different ways, by promoting DNA hypermutation and facilitating HPV integration thus contributing to an immunogenic phenotype, but also by cooperating with the epithelial growth factor receptor (EGFR) to promote resistance to therapy. Conclusion: The expression of sex hormone receptors may be of prognostic value in specific tumour subgroups, but the use of hormonal therapies for HNSCC is still not in close sight.Head-and-neck cancer comprises a group of malignancies affecting multiple sites including the oral cavity, the oropharynx, nasopharynx, hypopharynx, larynx and the salivary glands. Histologically, these lesions are most commonly squamous cell carcinomas (HNSCC) (1). An estimated 650,000 new cases occur yearly worldwide, along with 330 000 deaths from HNSCC (2). In the USA, HNSCC corresponds to 3% of all cancers with approximately 53,000 new cases and 10,800 deaths yearly. Males seem to be at higher risk, with a male to female ratio varying between 2:1 and 4:1 (3). Classically, alcohol and tobacco consumption have been identified as major risk factors for developing HNSCC (4, 5). Recently, infection with high-risk human papillomavirus (HPV) has been recognized as a risk factor for developing HNSCC (6). HPVpositive HNSCC is preferentially located at oropharyngeal sites, especially the tonsils and the tongue base, and shows distinguishing clinico-pathological features (7). Other risk factors for developing HNSCC include dietary or workplace exposure to environmental toxicants and genetic predisposition (8-10). Between 2005 and 2014, the incidence of HPV-positive HNSCC increased by 3% while that of classical lesions decreased by 2% (11). The increasing incidence of HPVpositive HNSCC motivated a significant effort to understand the biopathology of these lesions and adapt the current therapeutic approaches (12). A number of markers is currently in use or under study for identifying these lesions (e.g., immunohistochemistry for p16 IN...

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A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

Cited by 27 publications

References 38 publications

Papillomaviruses in Domestic Cats

Papillomaviruses in Domestic Cats

A First NGS Investigation Suggests No Association Between Viruses and Canine Cancers

Is There a Role for Sex Hormone Receptors in Head-and-neck Cancer? Links with HPV Infection and Prognosis

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