Feline Trauma and Critical Care Medicine

Kitchell, Barbara E.; Haskins, Steve C.

doi:10.1016/s0195-5616(84)50161-2

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…It was diagnosed histologically as a malignant fibrous tumour, but resolved spontaneously in the koala. The formation of vaccination-site fibrosarcomas is a well-recognised phenomenon in cats (Kitchell, 2005). In most other cases observed in koalas, the tumour has arisen spontaneously or from an unknown trigger.…”

Section: Fibrosarcomamentioning

confidence: 99%

Untitled

Pye¹,

Johnson²,

Greenwood³

2014

Tech. Rep. Aust. Mus., Online

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Koalas in US zoos were screened for koala retroviruses in an effort to determine the viral mechanism for koala retrovirus induced malignant neoplasias. Although the previously characterized koala retrovirus (KoRV-A) was present in all US koalas, some koalas were also infected by a novel koala retrovirus, termed KoRV-B. The genome of KoRV-B is highly related to KoRV-A; however, certain regions within the viral genome, including the envelope gene, displayed diversity. These differences are sufficient to allow KoRV-B to employ a receptor (a thiamine transporter) that differs from that used by KoRV-A (a phosphate transporter). Of great interest was the strong correlation between the presence of KoRV-B and malignant disease (lymphomas) in koalas. All koalas that died from lymphoma were KoRV-B positive as were the dead joeys ejected from the pouch of KoRV-B positive dams. We found no evidence of KoRV-B transmission from sires to offspring but did from dam to offspring through de novo infection, rather than via genetic inheritance like KoRV-A. Detection of KoRV-B in native Australian koalas should provide a history, and a mode for remediation, of leukemia/lymphoma currently endemic in this population.Eiden, Maribeth V. 2014. A novel exogenous retrovirus isolated from koalas (Phascolarctos cinereus) with malignant neoplasias in a United States zoo. In The Koala and its Retroviruses: Implications for Sustainability and Survival, ed.

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Section: Fibrosarcomamentioning

confidence: 99%