Feline Systemic Hypertension

Stepien, Rebecca L.

doi:10.1016/j.jfms.2010.11.008

Cited by 51 publications

(59 citation statements)

References 34 publications

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“…Female cats were approximately 4 times less likely than males to have a menace response at the end of this study. Although this predilection is not highlighted in recent reviews, a similar gender distribution was present in a previous study describing the ocular lesions associated with hypertension in cats . There were 43 (62.3%) female and 26 male cats in the study reported by Maggio et al Although this study also evaluated the NCSU‐VTH patient population, it covered a different time period (1985‐1998 vs 2005‐2015).…”

Section: Discussionsupporting

confidence: 62%

“…There are a number of studies assessing the effect of blood pressure on cardiac and renal disease, and survival time of cats with systemic hypertension, but there is very little information available on the rate of retinal reattachment, return of vision, or long‐term visual outcome in cats with hypertensive chorioretinopathy . Thus, the goal of this study was to investigate the factors associated with long‐term visual outcome in cats with retinal disease attributable to systemic hypertension presenting to specialty ophthalmology practices.…”

Section: Introductionmentioning

confidence: 99%

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Visual outcome in cats with hypertensive chorioretinopathy

Young

Zheng

Davidson

et al. 2018

Veterinary Ophthalmology

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Visual outcome in cats with hypertensive chorioretinopathy

Young

Zheng

Davidson

et al. 2018

Veterinary Ophthalmology

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“…Complete blood hematology, chemistry, and urinalysis were unremarkable, and plasma taurine levels were within normal reference intervals in both cats. Indirect blood pressure measurements obtained under general anesthesia in both cats were found to be within normal reference ranges for domestic felids474849.…”

Section: Resultsmentioning

confidence: 65%

Early-Onset Progressive Retinal Atrophy Associated with an IQCB1 Variant in African Black-Footed Cats (Felis nigripes)

Pearce

Gandolfi

et al. 2017

Sci Rep

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African black-footed cats (Felis nigripes) are endangered wild felids. One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age. The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduced direct and consensual pupillary light reflexes, phenotypic presence of retinal degeneration, and a non-recordable electroretinogram with negligible amplitudes in both eyes. Whole genome sequencing, conducted on two unaffected parents and one affected offspring was compared to a variant database from 51 domestic cats and a Pallas cat, revealed 50 candidate variants that segregated concordantly with the PRA phenotype. Testing in additional affected cats confirmed that cats homozygous for a 2 base pair (bp) deletion within IQ calmodulin-binding motif-containing protein-1 (IQCB1), the gene that encodes for nephrocystin-5 (NPHP5), had vision loss. The variant segregated concordantly in other related individuals within the pedigree supporting the identification of a recessively inherited early-onset feline PRA. Analysis of the black-footed cat studbook suggests additional captive cats are at risk. Genetic testing for IQCB1 and avoidance of matings between carriers should be added to the species survival plan for captive management.

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“…( [4]) showed a prevalence of hypertension of 13% in a population of 303 untreated hyperthyroid cats, and an incidence of 23% when initially normotensive cats from the same population were treated medically and/or surgically for hyperthyroidism. Blood pressure should be measured at diagnosis and monitored during the first 6 months after restoration of euthyroidism and then biannually as recommended by Stepien ( [3a]). If present, hypertension should be treated [OEG D].…”

Section: Monitoring Antithyroid Drug Treatmentmentioning

confidence: 99%

Best practice for the pharmacological management of hyperthyroid cats with antithyroid drugs

Daminet

Kooistra

Fracassi

et al. 2013

J of Small Animal Practice

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Pha rmacological management of feline hyperthyroidism offers a practical treatment option for many hyperthyroid cats. Two drugs have been licensed for cats in the last decade: methimazole and its pro-drug carbimazole. On the basis o f current evidence and available tablet sizes, starting doses of 2·5 mg methimazole twice a day and 10 to 1 5 mg once a day for the sustained release formulation of carbimazole are recommended. These doses should then be titrated to effect in order to obtain circulating total thyroxine (TT4) concentrations in the lower half of the reference interval. Treated cases should be monitored for side-effects, especially during the first months of treatment. Some side-effects may require discontinuation of treatment. At eac h monitoring visit, clinical condition and quality of life should also be evaluated, with special attention to possible development of azotaemia, hypertension and iatrogenic hypothyroidism. When euthyroidism has been achieved, monitoring visits are recommended after 1 month, 3 months and biannually thereafter. Cats with pre-existing azotaemia have shorter survi val times. However, development of mild azotaemia during the initial course of treatment, unless associated with hypothyroidism, does not appear to decrease survival time. The long-term effects of chronic medic al management require further study.

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Feline Systemic Hypertension

Abstract: numerous well-designed clinical studies have greatly advanced our understanding of the most appropriate methods of diagnosis and therapy of feline hypertension.

Cited by 51 publications

References 34 publications

Visual outcome in cats with hypertensive chorioretinopathy

Visual outcome in cats with hypertensive chorioretinopathy

Early-Onset Progressive Retinal Atrophy Associated with an IQCB1 Variant in African Black-Footed Cats (Felis nigripes)

Best practice for the pharmacological management of hyperthyroid cats with antithyroid drugs

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