Feline parvovirus infection and associated diseases

Stuetzer, Bianca; Hartmann, Katrin

doi:10.1016/j.tvjl.2014.05.027

Cited by 114 publications

(166 citation statements)

References 55 publications

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“…Replication in the bone marrow and other lymphoid tissues commonly results in immunosuppression, as a result of decreased leukocyte numbers and impaired T‐cell responsiveness . Often, patients die because of complications, such as secondary bacteremia, dehydration, and disseminated intravascular coagulopathy . Severe illness is more common in young and unvaccinated kittens in which the mortality rate can approach 90% …”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia

Petini

Drigo

Zoia

2020

Veterinary Internal Medicne

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Background Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats. Objective To assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia. Animals Client‐owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both. Methods Retrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional‐hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis. Results Seventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668‐0.873; P < .0001). Conclusion and Clinical Relevance Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.

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Section: Introductionmentioning

confidence: 99%

“…Often, patients die because of complications, such as secondary bacteremia, dehydration, and disseminated intravascular coagulopathy . Severe illness is more common in young and unvaccinated kittens in which the mortality rate can approach 90% …”

Section: Introductionmentioning

confidence: 99%

Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia

Petini

Drigo

Zoia

2020

Veterinary Internal Medicne

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“…Viral diarrhea is common in cats, especially in young kittens, and it is also a major threat to their health. It is commonly recognized that feline panleukopenia virus (FPV) is the major virus that causes diarrhea in cats [21]. Over the past few years, more diarrhea-related viruses, such as feline bocavirus (FBoV) [10], feline astrovirus (FeAstV) [11] and feline kobuvirus (FeKoV) [4], have been described in cats, and new detection techniques have been developed and applied [17].…”

Section: Introductionmentioning

confidence: 99%

Development and application of a multiplex PCR method for the simultaneous detection and differentiation of feline panleukopenia virus, feline bocavirus, and feline astrovirus

Zhang

Niu

et al. 2019

Arch Virol

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A multiplex polymerase chain reaction (mPCR) assay was developed to detect and distinguish feline panleukopenia virus (FPV), feline bocavirus (FBoV) and feline astrovirus (FeAstV). Three pairs of primers were designed based on conserved regions in the genomic sequences of the three viruses and were used to specifically amplify targeted fragments of 237 bp from the VP2 gene of FPV, 465 bp from the NP1 gene of FBoV and 645 bp from the RdRp gene of FeAstV. The results showed that this mPCR assay was effective, because it could detect at least 2.25-4.04 × 10 4 copies of genomic DNA of the three viruses per μl, was highly specific, and had a good broad-spectrum ability to detect different genotypes of the targeted viruses. A total of 197 faecal samples that had been screened previously for FeAstV and FBoV were collected from domestic cats in northeast China and were tested for the three viruses using the newly developed mPCR assay. The total positive rate for these three viruses was 59.89% (118/197). From these samples, DNA from FPV, FBoV and FeAstV was detected in 73, 51 and 46 faecal samples, respectively. The mPCR testing results agreed with the routine PCR results with a coincidence rate of 100%. The results of this study show that this mPCR assay can simultaneously detect and differentiate FPV, FBoV and FeAstV and can be used as an easy, specific and efficient detection tool for clinical diagnosis and epidemiological investigation of these three viruses.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…Disease prophylaxis rather than treatment or management is a cardinal principle of modern veterinary medicine, and one of the most effective weapons we have in the war against feline viral diseases is still vaccination. This point is elegantly made in the review paper on feline parvoviruses (Stuetzer and Hartmann, 2014) and in the experimental study on the efficacy of intranasal and subcutaneous vaccination against feline herpesvirus (Reagan et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

Feline infectious diseases: Our curiosity could be their salvation

Litster

2014

The Veterinary Journal

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Feline parvovirus infection and associated diseases

Cited by 114 publications

References 55 publications

Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia

Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia

Development and application of a multiplex PCR method for the simultaneous detection and differentiation of feline panleukopenia virus, feline bocavirus, and feline astrovirus

Feline infectious diseases: Our curiosity could be their salvation

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