Feeding with dairy Propionibacterium acidipropionici CRL 1198 reduces the incidence of Concanavalin-A induced alterations in mouse small intestinal epithelium

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

“…Dairy propionibacteria have demonstrated to adhere to immobilized mucus [139]; to isolated mouse intestinal epithelial cells [140,141], to human intestinal cell lines [142][143][144] and in vivo to intestinal cells as was assessed by counting the adhering propionibacteria on the mucosa by a plate count method [124,125,137,145].…”

“…Other dairy species like P. acidipropionici strain Q4 was able to prevent the adhesion of Salmonella enteritidis and Escherichia coli to HT29 cells [144] whereas P. acidipropionici CRL 1198 regulates in vitro the growth of Bacteroides and Clostridium in cecal homogenates of mice supplemented with propionibacteria and/or inulin [33]. Mice consuming this strain delivered in water, milk or cheese showed a decrease in the number of anaerobes and coliforms in the caecal content one week after feeding [124,137,145]. P. acidipropionici CRL 1198 also prevented tissue colonization by Salmonella Typhimurium in mice [176].…”

“…Since the removal in vitro of Con A and AIL by dairy propionibacteria was an effective way to avoid the toxic effects against intestinal cells, we assessed in vivo the effects of Con A on some morphological and physiological parameters related to intestinal functionality such as small bowel architecture, main microflora components and disaccharidase activities of Balb/c mice after long term feeding with this lectin alone (8 mg/kg/day of Con A for 3 weeks) or with the simultaneous consumption of Propionibacterium acidipropionici CRL 1198 (5 x 10 8 CFU/mice/day) [145].…”

Selection of indigenous lactic acid bacteria to reinforce the intestinal microbiota of newly hatched chicken – relevance of in vitro and ex vivo methods for strains characterization

“…Other effects are related to the improvement of the mucosa maturation, which exert influence in nutrients absorption and weight gain. Probiotics also may contribute to xenobiotics metabolism or toxic compounds removal by binding them on the bacterial envelopes (Carasi et al, 2012;Peltonen et al, 2001;Zárate and Perez Chaia, 2012). Other potential mechanism of probiotic action, related to cell surface molecules interactions, is the co-aggregation with pathogens, which avoids their attachment to the host epithelium and further internalization (Keller et al, 2011).…”