Feeding of Enterococcus faecium NCIMB 10415 Leads to Intestinal miRNA-423-5p-Induced Regulation of Immune-Relevant Genes

Kreuzer-Redmer, Susanne; Bekurtz, Jennifer C.; Arends, Danny; Bortfeldt, Ralf; Kutz-Lohroff, Barbara; Sharbati, Soroush; Einspanier, Ralf; Brockmann, Gudrun A.

doi:10.1128/aem.04044-15

Cited by 30 publications

(17 citation statements)

References 37 publications

(33 reference statements)

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“…The main datum reveals a 2.11-fold increase of miR 423-5p and the related downregulation of the immune-relevant immunoglobulin lambda light C region (IGLC) and immunoglobulin kappa constant (IGKC) target genes [85]. On the same direction, Veltman et al profiled miRs from T84 monolayers before and after co-incubation with E. coli Nissle 1917.…”

Section: Gut Microbiota and Mirs Modulation: From Association To Causmentioning

confidence: 99%

MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

Sérino¹

2016

J Diabetes Metab

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The identification of molecular factors bridging gut microbiota dysbiosis to alterations of host metabolism still remains a major goal in biomedical research. In fact, on one hand, there is a worldwide consensus about the systemic impact, from brain to liver, from heart to adipose tissue, of gut microbiota dysbiosis. On the other hand, beyond the microbial production of short chain fatty acids and their vast metabolic properties, little is known about the molecular mechanisms linking a change in the activity of gut microbes to a modification of host cell metabolism. In this context, microRNAs (also known as miRs) are promising molecules which could allow explaining how dysbiosis is converted into metabolic outcomes since: 1-miRs are pleiotropic regulators of gene expression, targeting multiple mRNAs at once; 2-miRs expression in specific organs such as the intestine has been demonstrated to be under the control of gut microbiota; 3-alterations in miRs expression have been found in the majority of tissues targeted by gut microbiota dysbiosis during metabolic diseases such as liver, adipose tissue, pancreas, skeletal muscle, intestine, heart and also the brain. In this review publications in the growing field of miRsbased metabolic control at a systemic level will be discussed together with a putative link with gut microbiota dysbiosis.

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Section: Gut Microbiota and Mirs Modulation: From Association To Causmentioning

confidence: 99%

MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

Sérino¹

2016

J Diabetes Metab

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“…Heat-treated L. paracasei NCC 2461 downregulated miR-27a in peripheral blood mononuclear cells [32]. Enterococcus faecium NCIMB 10415 upregulated miR-423-5p and downregulated its target gene IGLC (immunoglobulin lambda light C region) in the intestine of piglets [33]. These studies show that different probiotics elicit different miRNA responses.…”

Section: Discussionmentioning

confidence: 79%

Time‐ and strain‐specific downregulation of intestinal EPAS1 via miR‐148a by Bifidobacterium bifidum

Taïbi

Singh

Chen

et al. 2017

Molecular Nutrition Food Res

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“…They found that feeding E. faecium affected the expression of miR-423-5p as well as regulating its target gene IGLC. Therefore, E. faecium bene ts the immune cells in the small intestine probably by affecting the expression of miR-423-5p [175].…”

Section: Modulation Of Microrna By Probioticsmentioning

confidence: 99%

Effects of Therapeutic Probiotics on Modulation of microRNAs

Davoodvandi

Marzban

Goleij

et al. 2020

Preprint

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Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential beneficial impact on human health. Probiotics compete with pathogenic microorganisms for adhesion sites within the gut, to antagonize them or to regulate the host immune response resulting in preventive and therapeutic effects. Therefore, dysbiosis, defined as an impairment in the gut microbiota, could play a role in various pathological conditions, such as lactose intolerance, gastrointestinal and urogenital infections, various cancers, cystic fibrosis, allergies, inflammatory bowel disease, and can also be caused by antibiotic side effects. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate gene expression in a post-transcriptional manner. miRNAs are biochemical biomarkers that play an important role in almost all cellular signaling pathways in many healthy and disease states. For the first time, the present review summarizes current evidence suggesting that the beneficial properties of probiotics could be explained based on the pivotal role of miRNAs.

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Feeding of Enterococcus faecium NCIMB 10415 Leads to Intestinal miRNA-423-5p-Induced Regulation of Immune-Relevant Genes

Cited by 30 publications

References 37 publications

MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

Time‐ and strain‐specific downregulation of intestinal EPAS1 via miR‐148a by Bifidobacterium bifidum

Effects of Therapeutic Probiotics on Modulation of microRNAs

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