Feed Restriction Modifies Intestinal Microbiota-Host Mucosal Networking in Chickens Divergent in Residual Feed Intake

Metzler‐Zebeli, Barbara U.; Siegerstetter, Sina-Catherine; Magowan, Elizabeth; Lawlor, Peadar G.; Petri, Renée M.; ́Connell, Niamh E. O; Zebeli, Qendrim

doi:10.1128/msystems.00261-18

Cited by 33 publications

(40 citation statements)

References 37 publications

(61 reference statements)

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“…A recent study has shown that dietary supplementation with STE could alter the microflora distribution in the cecum of broiler chickens ( Wu et al., 2019 ). The gut microbiota plays an important role in producing short-chain fatty acids and neuropeptides, which could affect the feed intake of animals ( Cryan et al., 2019 , Metzler-Zebeli et al., 2019a , Metzler-Zebeli et al., 2019b ). Because chickens are insensitive to sweet taste, promoted feed intake induced by STE supplementation might be associated with orexigenic neuropeptides secreted by the gut microbiota or the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

et al. 2020

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The objective of this study was to investigate the effects of dietary 3 kinds of sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens for 21 D. A total of one hundred ninety-two 1-day-old male Ross 308 broiler chicks were randomly divided into 4 treatments with 6 replicates for each treatment. The treatments were basal diet ( CON ), a basal diet supplemented with 250 mg/kg stevioside ( STE ), a basal diet supplemented with 100 mg/kg sucralose ( SUC ), and a basal diet supplemented with 600 mg/kg saccharin sodium ( SAC ). All birds were housed in 3-level battery cages. The results showed that dietary STE supplementation increased ( P < 0.05) growth performance, serum total protein, serum albumin, and jejunal antioxidant capacity of broiler chickens. Both SUC and SAC supplementation decreased ( P < 0.05) serum total protein and albumin. Dietary SAC supplementation impaired the intestinal integrity, permeability, and mucus layer of the jejunum in broiler chickens. In addition, SAC supplementation elevated ( P < 0.05) the transcription expression level of jejunal bitter taste receptors and induced excessive jejunal apoptosis. Our data suggest that STE could be potentially applied as a growth-promoting and antioxidant feed additive in broiler chickens. Whereas, dietary supplementation with high level SAC has side-effects on the jejunal physiological functions of broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

et al. 2020

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“…Sequence data were analyzed with the Quantitative Insights Into Microbial Ecology (QIIME) package version 1.9.1 (Caporaso et al, 2010) as previously described (Metzler-Zebeli et al, 2019). The sequences for the eight FMT samples (Siegerstetter et al, 2018a) were re-analyzed together with the current dataset.…”

Section: Methodsmentioning

confidence: 99%

“…Primers for target genes and housekeeping genes (HKG) as well as amplification conditions used were recently published by our group (Metzler-Zebeli et al, 2019). Amplifications were performed on the CFX96 Touch Real-Time PCR Detection System (Bio-Rad Laboratories Ges.m.b.H, Wien, Austria) using the following conditions: 95°C for 5 min, followed by 95°C for 10 s, 60°C for 30 s, and 72°C for 30 s for 40 cycles, followed by the generation of dissociation curves.…”

Section: Methodsmentioning

confidence: 99%

Fecal Microbiota Transplant From Highly Feed Efficient Donors Affects Cecal Physiology and Microbiota in Low- and High-Feed Efficient Chickens

et al. 2019

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Fecal microbiota transplants (FMT) may be used to improve chicken’s feed efficiency (FE) via modulation of the intestinal microbiota and microbe-host signaling. This study investigated the effect of the administration of FMT from highly feed efficient donors early in life on the jejunal and cecal microbiota, visceral organ size, intestinal morphology, permeability, and expression of genes for nutrient transporters, barrier function and innate immune response in chickens of diverging residual feed intake (RFI; a metric for FE). Chicks ( n = 110) were inoculated with the FMT or control transplant (CT) on 1, 6, and 9 days posthatch (dph), from which 56 chickens were selected on 30 dph as the extremes in RFI, resulting in 15 low and 13 high RFI chickens receiving the FMT and 14 low and 14 high RFI chickens receiving the CT. RFI rank and FMT only caused tendencies for alterations in the jejunal microbiota and only one unclassified Lachnospiraceae genus in cecal digesta was indicative of high RFI. By contrast, the FMT caused clear differences in the short-chain fatty acid (SCFA) profile in the crop and cecal microbiota composition compared to the CT, which indicated alterations in amylolytic, pullulanolytic and hemicellulolytic bacteria such as Lactobacillus , Dorea , and Ruminococcus . Moreover, the FMT caused alterations in intestinal development as indicated by the longer duodenum and shallower crypts in the ceca. From the observed RFI-associated variation, energy-saving mechanisms and moderation of the mucosal immune response were indicated by higher jejunal permeability, shorter villi in the ileum, and enhanced cecal expression of the anti-inflammatory cytokine IL10 in low RFI chickens. Relationships obtained from supervised multigroup data integration support that certain bacteria, including Ruminococcocaceae-, Lactobacillus- , and unclassified Clostridiales -phylotypes, and SCFA in jejunal and cecal digesta modulated expression levels of cytokines, tight-junction protein OCLN and nutrient transporters for glucose and SCFA uptake. In conclusion, results suggest that the intestine only played a moderate role for the RFI-associated variation of the present low and high RFI phenotypes, whereas modulating the early microbial colonization resulted in long-lasting changes in bacterial taxonomic and metabolite composition as well as in host intestinal development.

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“…Lactobacillus species have been usually correlated with higher performance and better health [19]. In contrast, two studies have reported Lactobacillus species in the ileum to be associated with low productivity [20].…”

Section: Chicken Productivity and Its Relationship With The Gut Micromentioning

confidence: 99%

“…However, the relationship between the gut microbiota composition and productive performance of chickens has not yet been fully elucidated. Some authors have reported that high feed efficiency is associated with less diverse gut microbiota in chicken [20], while others have linked higher bacterial communities' complexity and richness with better feed efficiency [21].…”

Section: Chicken Productivity and Its Relationship With The Gut Micromentioning

confidence: 99%

Gut Microbiota-Polyphenol Interactions in Chicken: A Review

Iqbal

Cottrell

Suleria

et al. 2020

Animals

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The gastrointestinal tract of the chicken harbors very complex and diverse microbial communities including both beneficial and harmful bacteria. However, a dynamic balance is generally maintained in such a way that beneficial bacteria predominate over harmful ones. Environmental factors can negatively affect this balance, resulting in harmful effects on the gut, declining health, and productivity. This means modulating changes in the chicken gut microbiota is an effective strategy to improve gut health and productivity. One strategy is using modified diets to favor the growth of beneficial bacteria and a key candidate are polyphenols, which have strong antioxidant potential and established health benefits. The gut microbiota-polyphenol interactions are of vital importance in their effects on the gut microbiota modulation because it affects not only the composition of gut bacteria but also improves bioavailability of polyphenols through generation of more bioactive metabolites enhancing their health effects on morphology and composition of the gut microbiota. The object of this review is to improve the understanding of polyphenol interactions with the gut microbiota and highlights their potential role in modulation of the gut microbiota of chicken.

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Feed Restriction Modifies Intestinal Microbiota-Host Mucosal Networking in Chickens Divergent in Residual Feed Intake

Cited by 33 publications

References 37 publications

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

Fecal Microbiota Transplant From Highly Feed Efficient Donors Affects Cecal Physiology and Microbiota in Low- and High-Feed Efficient Chickens

Gut Microbiota-Polyphenol Interactions in Chicken: A Review

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