Fecobionics characterization of female patients with fecal incontinence

Abstract

Defecatory disorders including fecal incontinence (FI) are diagnosed on the symptom pattern supplemented by anorectal manometry (ARM), the balloon expulsion test (BET), and endo-anal ultrasonography. In this study, we used a simulated stool named Fecobionics to study distinct defecation patterns in FI patients using preload-afterload diagrams and to provide comparative data on defecation indices (DIs) between passive and urge incontinent patients. All subjects had Fecobionics, endo-anal ultrasonography and ARM-BET done. The Fecobionics bag was distended in rectum until urge in 37 female patients (64.1 ± 1.5 yrs) and a group of normal subjects (NS, 12F, age 64.8 ± 2.8 yrs). Rear-front pressure (preload-afterload) diagrams and DIs were compared between groups. The FISI score in the patients was 8.6 ± 0.6. The NS did not report FI-related symptoms. All patients and NS defecated Fecobionics and ARM-BET within 2 min. The urge volume was 46.1 ± 3.6 and 35.3 ± 5.9 mL in the FI and normal groups (P > 0.1). The expulsion duration was 14.8 ± 2.4 and 19.8 ± 5.1 s for the two groups (P > 0.1). The preload-afterload diagrams demonstrated clockwise loops that clearly differed between the FI subtypes and NS. The DIs showed profound difference between patients and NS. Fecobionics data showed higher correlation with symptoms in FI patients than ARM-BET. Fecobionics obtained novel pressure signatures in subtypes of FI patients and NS. Fecobionics provides DI data that cannot be obtained with ARM-BET.

Consistency of Feces Affects Defecatory Function

“…Fecobionics represents a giant leap in the direction of improved physiological (bionics) studies of anorectal function and pathophysiology. [12][13][14][15][16][17][18][19][20][21][22][23][24][25]28 The novelty of this study is that it consistency of simulated feces to function.…”

“…Technological validation for Fecobionics was published 11,12 as well as physiological data, [13][14][15][16][17][18][19][20][21] and data on patients with FI and chronic constipation including obstructed defecators. [22][23][24][25] Furthermore, normal subject studies have been done recently with an upgraded wireless device that also A h e a d o f P r i n t captures the shape during evacuation. 12,17,20,21 Fecobionics made it possible to define several phenotypes in obstructed defecators.…”