Fecapentaene excretion and fecal mutagenicity in relation to nutrient intake and fecal parameters in humans on omnivorous and vegetarian diets

Kok, Jamie Mei-Lin; Faassen, A. van; Bausch-Goldbohm, R.A.; Hoor, F. ten; Kleinjans, Jos

doi:10.1016/0304-3835(92)90193-y

Cited by 18 publications

(2 citation statements)

References 47 publications

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“…Although fecapentaenes occur in faeces of the majority of Western populations, more detailed epidemiological studies have revealed some anomalies. For example, lower fecapentaene levels have been found in faeces from colorectal patients than in controls (Schiffman et al 1989) and faecal excretion of fecapentaenes is higher in vegetarians, who are at lower risk from colon cancer (de Kok et al 1992). These and other studies suggest that the more fecapentaene excreted the lower the risk of CRC.…”

Section: Fecapentaenesmentioning

confidence: 96%

Diet and cancer: assessing the risk

2002

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Globally, colorectal cancer (CRC) is a leading cause of mortality from malignant disease. Case–control and cohort studies provide strong support for a role of diet in the aetiology of CRC. However to establish causal relationships and to identify more precisely the dietary components involved, intervention studies in human subjects are required. Cancer is an impractical endpoint in terms of numbers, cost, study duration and ethical considerations. Consequently, intermediate biomarkers of the disease are required. This review aims to provide an overview of the intermediate endpoints available for the study of CRC, particularly non-invasive faecal biomarkers. Examples of their use in dietary intervention studies are given.

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Section: Fecapentaenesmentioning

confidence: 96%

Diet and cancer: assessing the risk

2002

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“…• Fecapentaenes are mutagenic products of intestinal bacterial metabolism [115,116]. The origin of their precursor is uncertain, but it seems that vegetarians excrete more fecapentaenes than omnivores [117]. A survey of 718 faecal samples indicated that 50% of samples that were mutagenic contained higher concentrations of fecapentaenes [118].…”

Section: Impact Of High Protein Intakes Upon Gut Metabolismmentioning

confidence: 99%

Obesity and Colorectal Cancer Risk: Impact of the Gut Microbiota and Weight-Loss Diets~!2009-09-07~!2009-09-23~!2010-07-13~!

Flint¹,

Wallace²

2010

TOOBESJ

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The link between obesity and colorectal cancer risk in man is well established. This review investigates the role that the intestinal microbial population plays in this link and the impact of weight-loss diets on colorectal cancer risk. Changes in the composition of the intestinal bacterial community have been implicated in contributing to obesity. The robustness of these claims is analysed here, along with the role of bacterial metabolism in colon cancer risk. Weight-loss diets, low in carbohydrate and high in protein and fat, present an additional hazard to individuals struggling with obesity. Intestinal bacteria ferment carbohydrates to products that are generally regarded as being beneficial to health and protective against cancer. Some commensal species also appear to suppress inflammation. On the other hand, when carbohydrate limits the growth of intestinal bacteria, protein is broken down and the amino acids released are fermented to products that are inflammatory and possibly carcinogenic. We advocate the inclusion of non-digestible but fermentable carbohydrate in weight-loss diets to avoid these problems. High-fat diets enhance the escape of fats to reach the intestine, the implications of which are not fully understood. Even more fat reaches the intestine when dietary lipase inhibitors or fat-absorbing non-digestible dietary additives are used. Consequences for gut health of the increased fat concentration in the intestine seem to vary between individuals, the possible reasons for which are discussed here.

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Nutritional and Microbial Modulation of Carcinogenesis

Huges¹,

Rowland²

2003

Gut Flora, Nutrition, Immunity and Health

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Fecapentaene excretion and fecal mutagenicity in relation to nutrient intake and fecal parameters in humans on omnivorous and vegetarian diets

Cited by 18 publications

References 47 publications

Diet and cancer: assessing the risk

Diet and cancer: assessing the risk

Obesity and Colorectal Cancer Risk: Impact of the Gut Microbiota and Weight-Loss Diets~!2009-09-07~!2009-09-23~!2010-07-13~!

Nutritional and Microbial Modulation of Carcinogenesis

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