Fecal microbiota transplantation: Safe, simple, and effective

Smith, Ellyn; Duarte-Chavez, Rodrigo; Samia, Hoda; Knight, Patrick; Tolentino, Julia C.; Wojda, Thomas R; Cornejo, Kristine M.; Siciliano, Mary; Geme, Berhanu; Stawicki, Stanislaw P.

doi:10.4103/ijam.ijam_33_18

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Fecal transplant quickly restores balance in the gut microbiota. 51 Unfortunately, in autoimmune diseases such as ulcerative colitis and Crohn's disease, the success of FMT is not as spectacular and the effectiveness is measured as the period of the obtained remission. 52 Some role may be played by the compatibility of the donor and the recipient, dependent on genetic factors, innate immune responses or even their diets.…”

Section: Resultsmentioning

confidence: 99%

Gut microbiota modification as an option in multiple sclerosis management

et al. 2020

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Introduction: Multiple sclerosis (MS) is caused by the abnormal activity of the immune system. It is believed that the pathological immune response may be initiated in the intestines, the area of the largest antigen presentation. This is where autoreactive T and B cells are activated, which constitutes the pathomechanism of this disease. In a healthy organism, normal gut microbiota mediates the balance between pro- and anti-inflammatory activity of the immune system. Aim: This paper aims at describing the healthy gut microbiota, its changes in MS patients, factors that influence its composition and therapeutic corrective possibilities. Material and methods: The paper is based on available medical literature. Results and discussion: It has been evidenced that in MS patients the gut microbiota is dominated by pro-inflammatory species. This may be caused by environmental factors, for instance, the diet, antibiotics or stimulants. Methods of the microbiota correction involve dietary change, prebiotics and probiotics as well as fecal microbiota transplantation (FMT). FMT is a particularly safe and promising method that has proven its efficiency on an animal model of MS. Conclusions: Experimental research has revealed that the correction of the gut microbiota may lead to MS remission or alleviation. FMT utilized in inflammatory bowel disease seems to be presently the most comprehensive intervention. Since only incidental reports of its efficiency in humans are presently available, further clinical studies are necessary.

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Section: Resultsmentioning

confidence: 99%

Gut microbiota modification as an option in multiple sclerosis management

et al. 2020

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The History of the Intestinal Microbiota and the Gut-Brain Axis

Lewandowska-Pietruszka

Figlerowicz

Mazur‐Melewska

2022

Pathogens

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The gut-brain axis and the intestinal microbiota have been an area of an intensive research in the last few years. However, it is not a completely novel area of interest for physicians and scientists. From the earliest centuries, both professionals and patients turned their attention to the gastrointestinal system in order to find the root of physical and mental disturbances. The approach to the gut-brain axis and the therapeutic methods have changed alongside the development of different medical approaches to health and illness. They often reflected the social changes. The authors of this article aim to provide a brief history of the gut-brain axis and the intestinal microbiota in order to demonstrate how important the study of these systems is for both scientists and medical professionals, as well as for the general public. We analysed the publications accessible through PubMed regarding the microbiota and gut-brain axis history. If available, we accessed the original historical sources. We conclude that although the history of this science might be long, there are still many areas that need to be researched, analysed, and understood in future projects. The interest in the subject is not diminishing, but rather it has increased throughout the years.

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Fecal microbiota transplantation: Safe, simple, and effective

Cited by 2 publications

References 89 publications

Gut microbiota modification as an option in multiple sclerosis management

Gut microbiota modification as an option in multiple sclerosis management

The History of the Intestinal Microbiota and the Gut-Brain Axis

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