Fecal Microbiota Transplantation for Primary Clostridium difficile Infection

Gnotobiotics and the Microbiome

“…the availability of defined microbiota rodent models offers unique opportunities to study hostemicrobiota interactions well beyond what may have been envisioned by Schaedler in 1965. " In fact, the current use of fecal transplantation in the treatment of primary Clostridium difficile infection as a cause of pseudomembranous colitis in humans is just one example (Gustafsson et al, 1999;Juul et al, 2018).…”

Current applications of fecal microbiota transplantation in intestinal disorders

“…Conventionally, antibiotics with metronidazole or vancomycin is the first‐line treatment to eradicate gut CDI, but 15% to 30% of patients experience recurrence, largely attributed to the persistence of C difficile spores. FMT, attempting to restore normal gut microbiota, is a reasonable treatment for primary CDI, but still under a phase III trial . Recurrence CDI became a clinical challenge because of declining efficacy of conventional antibiotics treatment with 40% to 60% recurrence rate .…”

“…FMT, attempting to restore normal gut microbiota, is a reasonable treatment for primary CDI, but still under a phase III trial. 26 Recurrence CDI became a clinical challenge because of declining efficacy of conventional antibiotics treatment with 40% to 60% recurrence rate. 27 The first report of FMT in recurrence CDI was reported by Schwan et al in 1983 with retention enema.…”

Intestinaler Crosstalk

“…von in Kapseln eingebrachtem Spenderstuhl wird die Akzeptanz und Praktikabilität dieser im Prinzip nicht neuen, aber sicherlich zukunftsträchtigen therapeutischen Maßnahme wesentlich steigern [43]. …”