Intestinaler Crosstalk

Druml, Wilfred

doi:10.1007/s00063-018-0475-1

Cited by 16 publications

(5 citation statements)

References 43 publications

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“…[ 5 – 7 ] However, simultaneous ligation of GL vessels or drainage of GLF in this model alleviated the conditions of ARDS. [ 8 ] Therefore, the gut is considered to be the origin of systemic inflammation responses [ 9 ] and the engine of MODS, [ 10 ] and plays an essential role in initiation of ARDS. This review attempts to unveil the potential mechanisms underlying how GL affects the lung and further gives rise to ARDS, as well as potential interventional targets under the condition of IRI.…”

Section: Introductionmentioning

confidence: 99%

Gut-lymph-lung pathway mediates sepsis-induced acute lung injury

Jin

Chen

et al. 2020

Chinese Medical Journal

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This review attempts to unveil the possible mechanisms underlying how gut lymph affects lung and further gives rise to acute respiratory distress syndrome, as well as potential interventional targets under the condition of ischemia-reperfusion injury. We searched electronic databases including PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, Google Scholar, Web of Science, and Embase to identify relevant literatures published up to December 2019. We enrolled the literatures including the Mesh Terms of “gut lymph or intestinal lymph and acute lung injury or acute respiratory distress syndrome.” Gut is considered to be the origin of systemic inflammation and the engine of multiple organ distress syndrome in the field of critical care medicine, whereas gut lymph plays a pivotal role in initiation of ischemia-reperfusion injury-induced acute respiratory distress syndrome. In fact, in the having been established pathologic model of sepsis leading to multiple organ dysfunction named by Gut Lymph theory, a variety of literatures showed the position and role of changes in gut lymph components in the initiation of systemic inflammatory response, which allows us to screen out potential intervention targets to pave the way for future clinic and basic research.

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Section: Introductionmentioning

confidence: 99%

Gut-lymph-lung pathway mediates sepsis-induced acute lung injury

Jin

Chen

et al. 2020

Chinese Medical Journal

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“…Moreover, they found that majority of patients had high intestinal inflammation (measured by the presence of metabolites such as LPS) [274]. Therefore, the use of prebiotic, probiotic, or metabolite treatments (for example, Prevotella spp., or changing butyrate metabolism) could be useful in the treatment of ALS [275].…”

Section: • Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review

Uceda,

Echeverry-Alzate,

Reiriz-Rojas

et al. 2023

IJMS

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The comprehensive narrative review conducted in this study delves into the mechanisms of communication and action at the molecular level in the human organism. The review addresses the complex mechanism involved in the microbiota–gut–brain axis as well as the implications of alterations in the microbial composition of patients with neurodegenerative diseases. The pathophysiology of neurodegenerative diseases with neuronal loss or death is analyzed, as well as the mechanisms of action of the main metabolites involved in the bidirectional communication through the microbiota–gut–brain axis. In addition, interventions targeting gut microbiota restructuring through fecal microbiota transplantation and the use of psychobiotics—pre- and pro-biotics—are evaluated as an opportunity to reduce the symptomatology associated with neurodegeneration in these pathologies. This review provides valuable information and facilitates a better understanding of the neurobiological mechanisms to be addressed in the treatment of neurodegenerative diseases.

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“… 1 Intestinal mucosal barrier is the first line of defense for non-specific infections. 2 The impair of intestinal mucosal barrier always makes the harmful substances of intestinal contents enter the body more easily, which is considered as one of the development factors of chronic low-grade inflammation. 3 Intestinal mucosal barrier, contact with a large number of intestinal microbiota directly, is closely related to the occurrence and development of hypertension and intestinal microbiota, 4 which plays an important role in the pathogenesis of hypertension.…”

Section: Introductionmentioning

confidence: 99%

An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration

Jiang

et al. 2021

Dose-Response

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It has been proven a close relationship between intestinal microbiota and hypertension. Valsartan is a widely used ARB antihypertensive drug; so far, the effect of valsartan on intestinal microbiota remains largely unexplored. Herein, we evaluated the composition, structure and metabolites of intestinal microbiota of spontaneously hypertensive rats (SHRs) after valsartan administration. In the present study, valsartan administration decreased intestinal microbiota diversity, altered gut microbiota composition, leading to 192 unique OTUs deficiency ( vs WKY rats) and 10 unique OTUs deficiency ( vs SHRs) and did not prove impaired intestinal mucosal barriers. Valsartan decreased the production of isobutyric acid and isovaleric acid in SCFAs. Our findings revealed valsartan administration induced far-reaching and robust changes to the intestinal microbiota of SHRs and provided a better understanding of the relationship between efficacy of valsartan and gastrointestinal tract reaction.

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Intestinaler Crosstalk

Cited by 16 publications

References 43 publications

Gut-lymph-lung pathway mediates sepsis-induced acute lung injury

Gut-lymph-lung pathway mediates sepsis-induced acute lung injury

Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review

An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration

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