Fecal Microbiota Transplant for Multidrug-Resistant Organism Decolonization Administered During Septic Shock

Gopalsamy, Srinivasa Nithin; Sherman, Amy C; Woodworth, Michael H.; Lutgring, Joseph D.; Kraft, Colleen S.

doi:10.1017/ice.2017.300

Cited by 11 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are five case reports of FMT for non-CDI sepsis [43,[80][81][82] (Table 2). These reports vary in quality, as some do not specify the suspected cause of sepsis [43,80,82].…”

Section: Fecal Microbiota Transplantmentioning

confidence: 99%

The gut microbiome’s role in the development, maintenance, and outcomes of sepsis

et al. 2020

Self Cite

View full text Add to dashboard Cite

The gut microbiome regulates a number of homeostatic mechanisms in the healthy host including immune function and gut barrier protection. Loss of normal gut microbial structure and function has been associated with diseases as diverse as Clostridioides difficile infection, asthma, and epilepsy. Recent evidence has also demonstrated a link between the gut microbiome and sepsis. In this review, we focus on three key areas of the interaction between the gut microbiome and sepsis. First, prior to sepsis onset, gut microbiome alteration increases sepsis susceptibility through several mechanisms, including (a) allowing for expansion of pathogenic intestinal bacteria, (b) priming the immune system for a robust pro-inflammatory response, and (c) decreasing production of beneficial microbial products such as short-chain fatty acids. Second, once sepsis is established, gut microbiome disruption worsens and increases susceptibility to end-organ dysfunction. Third, there is limited evidence that microbiome-based therapeutics, including probiotics and selective digestive decontamination, may decrease sepsis risk and improve sepsis outcomes in select patient populations, but concerns about safety have limited uptake. Case reports of a different microbiome-based therapy, fecal microbiota transplantation, have shown correlation with gut microbial structure restoration and decreased inflammatory response, but these results require further validation. While much of the evidence linking the gut microbiome and sepsis has been established in pre-clinical studies, clinical evidence is lacking in many areas. To address this, we outline a potential research agenda for further investigating the interaction between the gut microbiome and sepsis.

show abstract

“…There are five case reports of FMT for non-CDI sepsis [43,[80][81][82] (Table 2). These reports vary in quality, as some do not specify the suspected cause of sepsis [43,80,82].…”

Section: Fecal Microbiota Transplantmentioning

confidence: 99%

The gut microbiome’s role in the development, maintenance, and outcomes of sepsis

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies based on fecal microbiota transplantation offer promising results to eradicate multidrug-resistant organisms from the gut (1247). Phage therapy can be useful for eliminating particular drug-resistant clones from the microbiota (1248,1249).…”

Section: Targeting Restoration Of Susceptibilitymentioning

confidence: 99%

Evolutionary Pathways and Trajectories in Antibiotic Resistance

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition, several case reports indicate that non-CDI sepsis patients with prolonged ICU stay and complications including bacteremia, MDR bacterial infection, respiratory failure, and organ dysfunction significantly benefitted from FMT. A total of 5 patients received FMT, of which 4 showed clinical improvement and 1 died from non-FMT-related causes [ 65 – 68 ].…”

Section: Other System-related Neurological Diseasesmentioning

confidence: 99%

Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Huang

Zhou

et al. 2021

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that the gut microbiota plays an important role in the pathophysiology of neurological and psychiatric disorders through the microbiota-gut-brain axis. Therefore, reconstruction of the healthy gut microbiota is a promising new strategy for treating cerebral diseases. We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.).

show abstract

Fecal Microbiota Transplant for Multidrug-Resistant Organism Decolonization Administered During Septic Shock

Cited by 11 publications

References 10 publications

The gut microbiome’s role in the development, maintenance, and outcomes of sepsis

The gut microbiome’s role in the development, maintenance, and outcomes of sepsis

Evolutionary Pathways and Trajectories in Antibiotic Resistance

Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Contact Info

Product

Resources

About