Fecal Lactoferrin Is A Sensitive and Specific Marker in Identifying Intestinal Inflammation

Kane, Sunanda V.; Sandborn, William J.; Rufo, Paul A.; Zholudev, Anna; Boone, James H.; Lyerly, David M.; Camilleri, Michael; Hanauer, Stephen B.

doi:10.1111/j.1572-0241.2003.07458.x

Cited by 317 publications

(206 citation statements)

References 13 publications

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“…21,22 Interestingly, stool lactoferrin has been shown to be a sensitive marker of intestinal inflammation in patients with intestinal tract symptoms and is being used in clinical practice to identify patients with intestinal tract inflammation. 23 Our results suggest that the detection of lactoferrin protein levels in the stool might also be a practical noninvasive screening test for pancreatic inflammation or cancer invasion among patients with suspected pancreatic disease. However, since stool lactoferrin is a feature of many other luminal gastrointestinal diseases, stool lactoferrin measurement may be too nonspecific for diagnostic use, even among patients with suspected pancreatic disease.…”

Section: Discussionmentioning

confidence: 69%

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma

et al. 2005

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The non-neoplastic pancreatic parenchyma adjacent to infiltrating ductal adenocarcinoma demonstrates inflammation, fibrosis, acinar cell loss and small duct-like metaplasia of acinar cells. Similar morphologic changes are also observed in the setting of chronic pancreatitis. In addition, peritumoral acini have been shown to have alterations in gene expression even in the absence of morphological changes. To better understand the pancreatic acinar responses to infiltrating pancreatic ductal adenocarcinoma, we characterized gene expression patterns of pancreatic acinar tissue adjacent to infiltrating pancreatic ductal adenocarcinomas and compared them to gene expression patterns of acinar tissue affected by chronic pancreatitis as well as to those of normal pancreatic acini. Fresh-frozen pancreatic acinar tissue was microdissected from nine patients (three with pancreatic cancer, three with chronic pancreatitis, three with normal pancreata) using laser capture microdissection, and extracted RNA from each microdissection was subjected to two rounds of linear amplification and hybridized to oligonucleotide microarrays. Gene expression patterns were confirmed using quantitative RT-PCR and/or immunohistochemistry. A total of 20 genes was found to be overexpressed in peritumoral acinar tissue compared to normal acinar tissue and to acini affected by chronic pancreatitis. These 20 genes included pancreatitis-associated protein (HIP/PAP), a gene known to be overexpressed in acini adjacent to infiltrating pancreatic cancer, and the gene cartilage glycoprotein-39 (HC gp-39 or TKL-40). Serum HC gp-39 protein levels were significantly higher in patients with pancreatic cancer and in those with chronic pancreatitis than in controls without pancreatic disease. There was no significant difference in the levels of serum HC gp-39 in patients with pancreatic cancer and those with chronic pancreatitis. Our results demonstrate some of the molecular alterations in acinar cells that occur in response to adjacent infiltrating pancreatic ductal adenocarcinoma and reveal that such alterations can provide a rich source of markers of pancreatic cancer.

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Section: Discussionmentioning

confidence: 69%

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma

et al. 2005

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“…[49][50][51][52] However, most studies found no difference in the faecal levels of calprotectin and lactoferrin between IBS patients and healthy controls. 43,44,49,50,[52][53][54][55][56][57][58][59] Only one publication reported that increased levels of faecal calprotectin were correlated with pain severity; however, this result was observed in children displaying both functional abdominal pain and IBS. 60 Key point: (i) Typically, no changes in the levels of the faecal inflammatory markers calprotectin and lactoferrin are reported in IBS patients.…”

Section: Key Pointsmentioning

confidence: 99%

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Matricon

Méleine

Gelot

et al. 2012

Aliment Pharmacol Ther

185

180

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This uncommissioned review article was subject to full peer-review. SUMMARY BackgroundIrritable bowel syndrome (IBS), one of the most common gastrointestinal disorders, markedly impairing patients' quality of life. Drug development for IBS treatment has been hampered by the lack of understanding of IBS aetiology. In recent years, numerous data have emerged that suggest the involvement of immune activation in IBS, at least in a subset of patients. AimTo determine whether immune activation and intestinal permeabilisation are more frequently observed in IBS patients compared with healthy controls. MethodsThe scientific bibliography was searched using the following keywords: irritable bowel syndrome, inflammation, immune activation, permeabilisation, intestine, assay, histology and human. The retrieved studies, including blood, faecal and histological studies, were analysed to provide a comprehensive and structured overview of the available data including the type of assay, type of inflammatory marker investigated or intestinal segment studied. ResultsImmune activation was more frequently observed in IBS patients than in healthy controls. An increase in the number of mast cells and lymphocytes, an alteration in cytokine levels and intestinal permeabilisation were reported in IBS patients. No consistent changes in the numbers of B cells or enterochromaffin cells or in mucosal serotonin production were demonstrated. ConclusionsThe changes observed were modest and often heterogeneous among the studied population. Only appropriate interventions improving irritable bowel syndrome symptoms could highlight and confirm the role of immune activation in this pathophysiology.

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“…In the present study we confirm the significant increase in lactoferrin but not calprotectin in stool samples. The patients and RT in the two studies are comparable, thus an explanation might be the relatively modest inflammation during RT, compared to the more extensive and pronounced inflammation present in inflammatory bowel diseases, where the two proteins are recognized as markers of intestinal inflammation [36,37].…”

Section: Inflammatory Markersmentioning

confidence: 99%

Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

Larsen

Bjørge²,

Klementsen³

et al. 2007

Acta Oncologica

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Fecal Lactoferrin Is A Sensitive and Specific Marker in Identifying Intestinal Inflammation

Abstract: Fecal lactoferrin is sensitive and specific for detecting inflammation in chronic IBD. This noninvasive test may prove useful in screening for inflammation in patients presenting with abdominal pain and diarrhea.

Cited by 317 publications

References 13 publications

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

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