Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma

Jovanovic, Milan; Gajovic, Nevena; Zdravković, Nataša; Jovanović, Marina; Jurišević, Milena; Vojvodić, Danilo; Maric, Veljko; Arsenijević, Aleksandar; Jovanović, Ivan

doi:10.1155/2018/8031328

Cited by 13 publications

(5 citation statements)

References 49 publications

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“…Our recent research has shown higher systemic concentration of Gal-3 in end stage renal disease patients infected with hepatitis C virus, suggesting on hepatoprotective role of Gal-3 from virus destruction[38]. Our other study revealed higher fecal concentration of Gal-3 and higher Gal-3/TNF-α ratio in patients with more severe form of colorectal cancer, thus suggesting immunosuppressive effect of Gal-3 on antitumor immune response[39]. Moreover, Tsai et al[40] showed that Gal-3 favors accumulation of regulatory T cells in the colon mucosa which suppresses inflammation and decreases the severity of dextran sulfate sodium-induced colitis.…”

Section: Discussionmentioning

confidence: 97%

Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Jovanović

Marković

Gajovic

et al. 2019

WJG

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BACKGROUNDUlcerative colitis (UC) is a chronic disease characterized by inflammation of intestinal epithelium, primarily of the colon. An increasing prevalence of metabolic syndrome (MetS) in patients with UC has been documented recently. Still, there is no evidence that MetS alters the course of the UC.AIMTo test the influence of the MetS on the severity of UC and the local and systemic immune status.METHODSEighty nine patients with de novo histologically confirmed UC were divided in two groups, according to ATP III criteria: Group without MetS (no MetS) and group with MetS.RESULTSClinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10 (IL-10) and fecal content of Galectin-3 (Gal-3) was observed in subjects with UC and MetS, compared to subjects suffering from UC only. This was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-17 (IL-17) in the sera as well as Gal-3 over TNF-α and IL-17 in feces of UC patients with MetS. Further, the patients with both conditions (UC and MetS) had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina propria.CONCLUSIONLocal dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC.

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Section: Discussionmentioning

confidence: 97%

Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Jovanović

Marković

Gajovic

et al. 2019

WJG

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“…A lot of studies have demonstrated pleiotropic biological functions of Gal-3. Our previous studies about Gal-3 revealed the hepatoprotective function of Gal-3 from hepatitis C virus damage, as well as the immunosuppressive role of Gal-3 on antitumor immunity [ 44 , 45 ]. Filer et al [ 46 ] showed that Gal-3 stimulates persistence of the inflammatory infiltrate in patients with rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study

Milošević

Jurišević

Grbovic

et al. 2022

IJERPH

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Background: Gonarthrosis and diabetes mellitus are two diseases that are increasingly being linked. The aim of this study was to quantify serum levels of Gal-3, pro- and anti-inflammatory cytokines (including their ratios and correlations), and participant’s condition (pain, stiffness, functional limitations) in gonarthrosis patients with and without diabetes mellitus. Methods: A between-subject, cross-sectional experimental design was adopted. Serum levels of TNF-α, IL-6, IL-12, IL-23, IFN-γ, IL-17, IL-10, Gal-3, and WOMAC score were measured. Results: Gonarthrosis patients with diabetes mellitus had significantly (p < 0.05) lower levels of TNF-α, IL-6, IL-12, IL-17, IFN-γ, and Gal-3 compared to gonarthrosis patients without diabetes mellitus. On the other hand, IL-10/TNF-α, IL-10/IL-6, IL-10/IL-12, Gal-3/TNF-α, Gal-3/IL-6, and Gal-3/IL-12 (p = 0.001) were significantly higher (p < 0.05) in gonarthrosis with diabetes mellitus. Moderate–large correlation (p < 0.05) was detected between the serum values of Gal-3 and pro- and anti-inflammatory cytokines, including IL-12 (r = 0.575), IL-10 (r = 0.535), TNF-α (r = 0.306), and IL-23 (r = 0.323). WOMAC index was significantly lower (p < 0.05) in gonarthrosis patients without diabetes mellitus compared to gonarthrosis patients with diabetes mellitus. Conclusions: Correlation between Gal-3 and proinflammatory cytokines and its dominance over proinflammatory cytokines implicate the potential role of Gal-3 in preventing cartilage destruction.

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“…Galectin-3 is also highly abundant in stool, and fecal galectin-3 levels were increased in colorectal carcinoma patients with advanced tumor node metastasis (TNM) score, higher nuclear grade, poor tumor tissue differentiation and metastatic disease ( Figure 4 ). Positive correlations between fecal galectin-3 concentrations and the cancer biomarkers alpha-fetoprotein and carcinoembryonic antigen were also observed [ 178 ]. Thus, the determination of not only urinary but also fecal galectin-3 levels might provide useful clinical information in advanced colorectal cancers.…”

Section: Adipokines In Urine and Fecesmentioning

confidence: 99%

Fecal and Urinary Adipokines as Disease Biomarkers

et al. 2023

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The use of biomarkers is of great clinical value for the diagnosis and prognosis of disease and the assessment of treatment efficacy. In this context, adipokines secreted from adipose tissue are of interest, as their elevated circulating levels are associated with a range of metabolic dysfunctions, inflammation, renal and hepatic diseases and cancers. In addition to serum, adipokines can also be detected in the urine and feces, and current experimental evidence on the analysis of fecal and urinary adipokine levels points to their potential as disease biomarkers. This includes increased urinary adiponectin, lipocalin-2, leptin and interleukin-6 (IL-6) levels in renal diseases and an association of elevated urinary chemerin as well as urinary and fecal lipocalin-2 levels with active inflammatory bowel diseases. Urinary IL-6 levels are also upregulated in rheumatoid arthritis and may become an early marker for kidney transplant rejection, while fecal IL-6 levels are increased in decompensated liver cirrhosis and acute gastroenteritis. In addition, galectin-3 levels in urine and stool may emerge as a biomarker for several cancers. With the analysis of urine and feces from patients being cost-efficient and non-invasive, the identification and utilization of adipokine levels as urinary and fecal biomarkers could become a great advantage for disease diagnosis and predicting treatment outcomes. This review article highlights data on the abundance of selected adipokines in urine and feces, underscoring their potential to serve as diagnostic and prognostic biomarkers.

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Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma

Cited by 13 publications

References 49 publications

Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study

Fecal and Urinary Adipokines as Disease Biomarkers

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