Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in the human gut. However, there is limited information on the immune regulatory effects of this bacterium. We confirmed that the administration of green tea increases the abundance of FP in the gut microbiota and investigated the effect of FP in a mouse colitis model. Mice were orally administered FP for 10 consecutive days; colonic inflammation was evaluated daily on the basis of stool consistency, gross rectal bleeding, and body weight. In the dextran sodium sulfate model, FP-exposed animals exhibited lower levels of inflammation and strong inhibition of interleukin (IL)-17 signaling. Moreover, lipoteichoic acid from FP was identified as the active component mediating IL-17 suppression. Thus, oral administration of FP appears to modulate gut inflammation and represents a viable and inexpensive oral microbial therapeutic.

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“…Fecal samples were prepared as previously reported ( 24 ). Feces were collected and stored −80°C until analysis.…”

Section: Methodsmentioning

confidence: 99%

Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17

et al. 2021

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“…MetS affects the course of the UC by alleviating the clinical presentation and severity of the disease (Jovanovic et al 2019). Milder form of UC in patients with MetS was accompanied by higher level of Gal-3 and interleukin-10 and less pronounced lymphocytes infiltration in affected tissue (Jovanovic et al 2019). Still, MetS is complex disease that goes through multiple stages and it is not known how individual stages affect the course of the UC.…”

Section: Discussionmentioning

confidence: 99%

“…As described in our previous study, the blood and feces were collected from UC patients with MetS at 8:00 a.m. (Jovanovic et al 2019). Sera and liquid feces fraction were separated and stored at −80°C before use.…”

Section: Measurement Of Cytokines Levels In Serum and Fecesmentioning

confidence: 99%

“…As described previously, immune cells of the colon were isolated from all patients included in the study (Rogler et al 1998;Acovic et al 2018;Jovanovic et al 2019). After the biopsy, tissue samples were washed and incubated for 10 minutes in medium with 1 mM EDTA at 37°C.…”

Section: Analysis Of Colon Infiltrating Cells By Flow Cytometrymentioning

confidence: 99%

“…Recently, we revealed that patients with MetS have milder form of UC (Jovanovic et al 2019). It appears that MetS attenuates colon inflammation that is diagnosed as clinically and endoscopically milder disease.…”

Section: Introductionmentioning

confidence: 99%

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Increased Severity of Ulcerative Colitis in the Terminal Phase of the Metabolic Syndrome

Jovanović

Jurišević

Gajovic

et al. 2021

Tohoku J. Exp. Med.

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Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that different stages of metabolic syndrome alter the course of the ulcerative colitis. The aim of this study was to dissect out how progression of the metabolic syndrome impacted the biology of ulcerative colitis and severity of clinical presentation. Seventy-two patients (41 men and 31 women, 22-81 years old) were enrolled in this observational cross-sectional study. Concentrations of proand anti-inflammatory cytokines in serum and feces samples were measured and phenotype of colon infiltrating cells was analyzed. Patients in the terminal phase of the metabolic syndrome have clinically and pathohistologically more severe form of ulcerative colitis, which is followed by decreased concentrations of systemic galectin-1, increased values of systemic pro-inflammatory mediators and increased influx of lymphocytes in affected colon tissue. Our data suggest that reduced concentrations of galectin-1 and predomination of the pro-inflammatory mediators in patients with terminal stage of the metabolic syndrome enhance local chronic inflammatory response and subsequent tissue damage, and together point on important role of galectin-1 in immune response in ulcerative colitis patients with the metabolic syndrome.

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Impact of pectin with various esterification degrees on the profiles of gut microbiota and serum metabolites

Fan

Tan

et al. 2022

Appl Microbiol Biotechnol

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Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Cited by 25 publications

References 40 publications

Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17

Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17

Increased Severity of Ulcerative Colitis in the Terminal Phase of the Metabolic Syndrome

Impact of pectin with various esterification degrees on the profiles of gut microbiota and serum metabolites

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