Febrile Morbilliform Rash as a Clinical Presentation of COVID-19 in a Pediatric Patient

Almutairi, Muneer; Azizalrahman, Amani

doi:10.14740/ijcp408

Cited by 3 publications

(1 citation statement)

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“…Some incidences of COVID-19 infection in children and adults have been accompanied by distinctive morbilliform rashes. 49,50 Spongiosis and minor cutaneous perivascular lymphocytic infiltrates have been seen in histologic investigations of such instances, indicating immune-mediated pathogenesis rather than a direct viral action. 51 Therefore, it is likely that the morbilliform rashes generated by the COVID-19 vaccination are similarly the consequence of immune activation, although the precise mechanism by which this occurs is yet unclear.…”

Section: Morbilliform Rashesmentioning

confidence: 99%

Dermatological Complications of COVID 19 Vaccines: An Updated Review

Alsadi

John

2023

Natl J Community Med

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Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the 2019 coronavirus disease (COVID-19) pandemic, have been rapidly developed and authorized. However, recent studies showed that COVID-19 vaccination is associated with a wide range of dermatological reactions. The most prevalent adverse dermatological reaction observed in observational studies was a delayed large local reaction (DLRs), which is characterized by the appearance of an erythematous and edematous patch at the injection site four days or more after vaccination. Most of these reactions are common in females and resolve spontaneously within a few days to a weak. The second dose of the vaccine was associated with a higher incidence of cutaneous reactions compared to the first dose but milder in intensity. It seems that the Moderna vaccine is associated with a higher incidence of these adverse events compared to the Pfizer vaccine. Furthermore, mRNA vaccines had a higher incidence than vector-based and inactivated vaccines. There is a lack of evidence regarding the side events of the Johnson & Janssen vaccine. Further long-term, multicenter studies are required to compare these vaccines and highlight the best practice in managing these reactions.

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Section: Morbilliform Rashesmentioning

confidence: 99%

Dermatological Complications of COVID 19 Vaccines: An Updated Review

Alsadi

John

2023

Natl J Community Med

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COVID-19 Vaccines and the Skin

Sun

Fathy

McMahon

et al. 2021

Dermatologic Clinics

104

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: In 2021, we entered a new phase of the COVID-19 pandemic. As mass vaccinations are underway and more vaccines are approved, it is increasingly important for dermatologists to recognize potential cutaneous adverse events. In this article we review the dermatologic manifestations of COVID-19 vaccines worldwide as reported in clinical trial data and summarize additional observational reports of skin reactions to COVID-19 vaccines. Early-onset local injection reactions were the most common cutaneous side effects observed in clinical trials, while delayed injection reactions were the most common cutaneous side effect reported outside of clinical trials. Understanding the landscape of cutaneous manifestations to COVID-19 vaccines is key to providing appropriate vaccine guidance.

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