Febrile Convulsions Induced by Microwaves and the Alteration in Behavior of Albino Mouse OF1

Carratalá, Francisco Antonio Martínez; Benavent, Manuel Moya

doi:10.1159/000243389

Cited by 4 publications

(2 citation statements)

References 20 publications

(31 reference statements)

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“…The suggestion that FSs are causally related to the development of TLE is in line with the longstanding notion that “seizures beget seizures.” A number of animal models for FSs have been developed to study whether FSs induce epileptogenesis. Most animal models for FSs aim to mimic fever by increasing the body temperature, which can be achieved by exposing the animals to a heat source such as a microwave (11,12), infrared irradiation (13), or warm water (14). In the present study, we used the immature rat model developed by Baram et al (15).…”

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Gender Differences in Febrile Seizure–induced Proliferation and Survival in the Rat Dentate Gyrus

et al. 2005

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Summary:Purpose: Febrile seizures are fever-associated early-life seizures that are thought play a role in the development of epilepsy. Seizure-induced proliferation of dentate granule cells has been demonstrated in several adult animal models and is thought to be an integral part of epileptogenesis. The aim of the present study was to investigate proliferation and survival of dentate gyrus (DG) cells born after early-life hyperthermia (HT)-induced seizures in male and female rats.Methods: At postnatal day (PN) 10, male and female rats were exposed to heated air to induce seizures. Littermates were used as normothermia controls. Convulsive behavior was observed by two researchers. From PN11 to PN16, rats were injected with bromodeoxyuridine (BrdU) to label dividing cells. The number of BrdU-immunoreactive cells in the DG was counted at PN17 and PN66.Results: At PN17, male as well as female HT rats had the same amount of BrdU-positive cells compared with controls. At PN66, significantly more BrdU-positive cells were left in HT females (53%) than in controls (44%, percentage of BrdU-positive cells at PN17), whereas no difference was found between HT males and male controls. The net result of proliferation and survival at PN66 was that female HT rats had the same number of BrdUimmunoreactive cells as controls, whereas male HT rats had 25% more BrdU-immunoreactive cells than did controls (p < 0.05).Conclusions: Early-life seizures cause a sexually dimorphic cytogenic response that results in an increased population of newborn DG cells in young adult males, while leaving that of young adult females unaltered.

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Gender Differences in Febrile Seizure–induced Proliferation and Survival in the Rat Dentate Gyrus

et al. 2005

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“…Whole body application of EMWs can eliminate the misinterpretation caused by regional applications. Carratala and Moya used microwaves as an indicator of febrile seizures in neonatal mice and concluded that they had no harmful effects [17]. Body temperature was not measured in the current study.…”

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confidence: 89%

What is the impact of electromagnetic waves on epileptic seizures?

Çınar

Sahin

Erdinç

2013

Med Sci Monit Basic Res

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BackgroundThe effects of electromagnetic waves (EMWs) on humans and their relationship with various disorders have been investigated. We aimed to investigate the effects of exposure to different frequencies of EMWs in various durations in a mouse epilepsy model induced by pentylenetetrazole (PTZ).Material/MethodsA total of 180 4-week-old male mice weighing 25–30 g were used in this study. Each experimental group consisted of 10 mice. They were exposed to 900, 700, 500, 300, and 100 MHz EMWs for 20 hours, 12 hours and 2 hours. Following electromagnetic radiation exposure, 60 mg/kg of PTZ was injected intraperitoneally to all mice. Each control was also injected with PTZ without any exposure to EMW. The latency of initial seizure and most severe seizure onset were compared with controls.ResultsThe shortest initial seizure latency was noted in the 12-hour group, followed by the 700 MHz. The mean initial seizure latencies in the 2-hour EMW exposed group was significantly shorter compared to that in the 12- and 20-hour groups. There was no significant difference between 12- and 20-hour EMW exposed groups. There was a significant difference between control and 2- and 10-hour EMW exposed groups. No statistically significant differences were noted in mean latencies of the most severe seizure latency, following 20-, 12-, and 2- hour EMW exposed groups and control groups.ConclusionsOur findings suggest that acute exposure to EMW may facilitate epileptic seizures, which may be independent of EMW exposure time. This information might be important for patients with epilepsy. Further studies are needed.

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