Features of Subpopulation Composition of Blood Lymphocytes in Recipients Within the First Month After Liver Transplantation

Shutko, A N; Герасимова, О. А.; Ekimova, Ludmila P.; Жеребцов, Ф. К.; Granov, A M

doi:10.15825/1995-1191-2015-1-68-73

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…angiogenic T-lymphocytes, and certain other "regulatory" cells [17] [28] [29]. As most such cells are more radiosensitive than mature cells, high doses of radiation or cytotoxic anticancer drugs may weaken stimulation by such cells of tumor growth.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Tissue Regenerative Status on Hormesis in Dogs Irradiated during Their Lifespan

Shoutko¹,

Ekimova²

2017

OJBIPHY

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The goal of this study was to evaluate the influence of natural variation in the regenerative status of dog tissues on the signs of hormesis, which are evident after total body exposure to low daily doses of external gamma radiation throughout the lifespan. Ninety beagle dogs of both sexes were irradiated with cobalt 60 at 0.003 Gy/day commencing 1 year after birth to death. Control (n = 169) and irradiated animals underwent whole-life clinical observation and autopsy, and were then retrospectively divided into two subgroups with (W) or without benign tumors or tumors of unknown nature (WO) that were clinically recorded on single days throughout the lifespan. Radiation hormesis was only detected in subgroup WO, which had life span (LS) of 10.7 years in the absence of radiation. The radiogenic prolongation of life to 11.8 years in the WO subgroup (p < 0.05) was similar to that in the W control and irradiated W subgroups (11.8 and 11.5 years, respectively). The number of solid malignancies found upon autopsy of the control WO subgroup was less (39.5%) than that evident in the control W subgroup (60%). Compared to the irradiated W subgroup, irradiation of the WO subgroup was accompanied by a slight increase (1.14-fold) in the number of solid malignancies evident at autopsy and in the clinical signs of tissue atrophy and body weight loss (2.4-fold and 2.4-fold, respectively), but was accompanied by strong reductions in the extent of anemia and hemoblastoses (>10-fold for both). The data exclude the notion that radiation is associated with healing, but suggest that certain pathologies (e.g., hemoblastoses) may be substituted with other less dangerous somatic diseases in weaker animals only.

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Section: Introductionmentioning

confidence: 99%

The Effects of Tissue Regenerative Status on Hormesis in Dogs Irradiated during Their Lifespan

Shoutko¹,

Ekimova²

2017

OJBIPHY

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“…Обнаруженные сдвиги Т-хелперных клеток, а также повышение соотношения иммунорегуляторных субпопуляций (CD4+/CD8+) в крови согласуются с данными как отечественных, так и зарубежных работ из общей трансплантологии, отметивших подобную динамику этих показателей при пересадках солидных органов (почек и печени) [12,13].…”

Section: результаты и обсуждениеunclassified

Clinical significance of assessing the subpopulation composition of blood lymphocytes in patients with infectious corneal lesions in high-risk keratoplasty

Нероев

Балацкая

Chentsova

et al. 2020

Rossijskij oftalʹmologičeskij žurnal

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/л) выявлено достоверное повышение абсолютного количества дубль-позитивных Т-лимфоцитов (CD3+CD4+CD8+) по сравнению с контролем (0,009 ± 0,007 × 10 9 /л). Заключение. Выявленные изменения в клеточной составляющей иммунного статуса, общие для всех пациентов, характеризовались исключительно сдвигами Т-звена иммунитета. Индивидуальный анализ по характеру сдвигов Т-хелперов и CD4+/CD8+ в сторону повышения от нормы позволил качественно выделить III группу (с двумя и более КП). Полученные данные представляются важными для разработки критериев прогнозирования КП высокого риска и свидетельствуют о необходимости иммуносупрессии. Ключевые слова: инфекция; кератит; язвы роговицы; бельма роговицы; кератопластика высокого риска; субпопуляции лимфоцитов Конфликт интересов: отсутствует. Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах.

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“…Moreover, the CD25 is an early T-cell surface antigen, which coexists with TdT-antigen on young T cells in Pro-T2 / Rre-T1 stages of maturation [65]. The other regulatory T-cells presented by transitional stages of differentiation [66] depend quantitatively from a regenerative capacity of stem cells [67]. Some of them (double -negative CD3+CD4−CD8−) can be TdT-positive too [65], others have signs of incomplete maturity (CD62L) or signs of activated CD34+ hematopoietic progenitors (CXCR3, CD122) [24].…”

Section: Hematopoiesis and Tumor Tissuesmentioning

confidence: 99%

Immunity or morphogenesis in cancer development and treatment

Shoutko¹

2019

Integr Cancer Sci Therap

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Non-selective cytotoxic therapy of cancer is effective, acting harmfully for a host. Legal deep lymphocytopenia at conventional cytotoxic therapy, high risk of new malignancies after it, spreading of malignant cells through favorite lymph nodes, a restriction of immunocytes activity inside tumor at anti-angiogenic treatment does not feet the idea of host immune defense against spontaneous cancer. To understand these theoretical inconsistencies we discussed the development of a tumor and its microvessels, gradual exhaustion of hematopoietic stem cell number in blood and arising of cancer cachexia, ratio of infectious morbidity and cancer mortality in their interrelation, using an experimental, clinical data and population statistics. We concluded, that mentioned above and other principal discrepancies would become regularities, if the cells renewing in both malignant and normal tissues were taken as a result of the recently discovered morphogenesis activity of circulating mononuclear cells, originated from the bone marrow and presented by tissue's committed stem cells and some subsets of morpho-angiogenic lymphocytes.

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Features of Subpopulation Composition of Blood Lymphocytes in Recipients Within the First Month After Liver Transplantation

Cited by 3 publications

References 25 publications

The Effects of Tissue Regenerative Status on Hormesis in Dogs Irradiated during Their Lifespan

The Effects of Tissue Regenerative Status on Hormesis in Dogs Irradiated during Their Lifespan

Clinical significance of assessing the subpopulation composition of blood lymphocytes in patients with infectious corneal lesions in high-risk keratoplasty

Immunity or morphogenesis in cancer development and treatment

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