Features of Optical Coherence Tomography for the Diagnosis of Vogt–koyanagi–harada Disease

Liu, Xiyao; Xiao, Peng; Wang, Shuang; You, Qi Sheng; Li, Yibin; Xiao, Yuan Yuan; Jonas, Jost B.

doi:10.1097/iae.0000000000001076

Cited by 45 publications

(33 citation statements)

References 35 publications

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“…On the other hand, in VKH, these areas could represent inflammatory debris or macrophages engulfing shed outer segments. In fact, Xi et al reported that these areas were seen at a high frequency during evaluations 7 . In our current case, although the angiography showed the presence of choroidal hypoperfusion, there were no RPE defects found on OCT evaluations or any findings of inflammation during the slit lamp examination, such as the presence of both anterior chamber and anterior vitreous cells, flares, or vitreous opacifications.…”

Section: Discussioncontrasting

confidence: 44%

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Bilateral serous retinal detachment associated with subretinal fibrin-like material in a case of pregnancy-induced hypertension

Komoto

Maruyama

Hashida

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeTo describe a case of bilateral serous retinal detachment (SRD) associated with subretinal fibrin-like material (SRFM) in pregnancy-induced hypertension (PIH).ObservationsAngiography of a 31-year-old primigravida with PIH who developed acute bilateral SRD with SRFM after caesarean section showed choroidal hypoperfusion and dye leakage. Optical coherence tomography revealed irregularity of the ellipsoid zone and retinal pigment epithelium. The patient's visual acuity was hand motion in the both eyes at the initial examination. After 30 days, SRD and SRFM spontaneously disappeared. Moreover, the EZ returned and the visual acuity significantly improved to 20/25 in the right and 20/20 in the left eye.Conclusions and importanceAlthough there are reports on central serous chorioretinopathy or Vogt–Koyanagi–Harada disease, there have been no studies on SRFM complications in patients with PIH. In the current case, we speculated that SRFM was associated with acute intense choroidal ischemia and inflammation secondary to this ischemic condition. Distinguishing whether inflammation necessitating treatment is involved in SRFM may be difficult. Short observation intervals and frequent examinations are important to ensure that treatment timings are not missed.

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Section: Discussioncontrasting

confidence: 44%

“…SRFM has been observed with central serous chorioretinopathy (CSC) and posterior uveitis, such as in Vogt–Koyanagi–Harada disease (VKH) 7 . In CSC, it is possible that intense choroidal hyperpermeability and breaches in the RPE could allow a large molecule, such as fibrin, to enter from the sub-RPE into the subretinal spaces 8 .…”

Section: Discussionmentioning

confidence: 99%

Bilateral serous retinal detachment associated with subretinal fibrin-like material in a case of pregnancy-induced hypertension

Komoto

Maruyama

Hashida

et al. 2019

American Journal of Ophthalmology Case Reports

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“…The “T” sign (present in 41.2% of reported cases[ 8 ]) indicates fluid accumulation at the sub-Tenon’s space accompanied by enhancive scleral thickness. Recently, investigations of collective OCT findings revealed that the frequency of subretinal mass was exceedingly more common in acute VKH disease patients (80%) than in patients with posterior scleritis (15%); however, the incidence of RPE folds was higher in posterior scleritis patients (62%) than in acute VKH disease patients (55%)[ 8 ]. Our patient showed no signs of iritis in either eye and no signs of predominately neurological and auditory manifestations either.…”

Section: Discussionmentioning

confidence: 99%

Bilateral posterior scleritis presenting as acute primary angle closure: A case report

Chen

Duan

2021

WJCC

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BACKGROUND Scleritis is a rare disease and the incidence of bilateral posterior scleritis is even rarer. Unfortunately, misdiagnosis of the latter is common due to its insidious onset, atypical symptoms, and varied manifestations. We report here a case of bilateral posterior scleritis that presented with acute eye pain and intraocular hypertension, and was initially misdiagnosed as acute primary angle closure. Expanding the literature on such cases will not only increase physicians’ awareness but also help to improve accurate diagnosis. CASE SUMMARY A 53-year-old man was referred to our hospital to address a 4-d history of bilateral acute eye pain, headache, and loss of vision, after initial presentation to a local hospital 3 d prior. Our initial examination revealed bilateral cornea edema accompanied by a shallow anterior chamber and visual acuity reduction, with left-eye amblyopia (> 30 years). There was bilateral hypertension (by intraocular pressure: 28 mmHg in right, 34 mmHg in left) and normal fundi. Accordingly, acute primary angle closure was diagnosed. Miotics and ocular hypotensive drugs were prescribed, but the symptoms continued to worsen over the 3-d treatment course. Further imaging examinations ( i.e. , anterior segment photography and ultrasonography) indicated a diagnosis of bilateral posterior scleritis. Methylprednisolone, topical atropine, and steroid eye drops were prescribed along with intraocular pressure-lowering agents. Subsequent optical coherence tomography (OCT) showed gradual improvements in subretinal fluid under the sensory retina, thickened sclera, and ciliary body detachment. CONCLUSION Bilateral posterior scleritis can lead to secondary acute angle closure. Diagnosis requires ophthalmic accessory examinations ( i.e ., ultrasound biomicroscopy, B-scan, and OCT).

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“…OCT has been shown to be a useful tool to measure and monitor serous retinal detachments during the acute and chronic stages of VKH disease, with the ability to show shallow serous detachments not otherwise seen [60]. However, OCT is mainly better at showing extrachoroidal spillover retinal involvement and does not give information on subclinical smouldering choroidal disease.…”

Section: Optical Coherence Tomography (Oct) and Enhanced Depth Imaginmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease and Birdshot Retinochoroidopathy, Similarities and Differences: A Glimpse into the Clinicopathology of Stromal Choroiditis, a Perspective and a Review

Elahi

Herbort²

2019

Klin Monatsbl Augenheilkd

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The purpose of this work was to give a comprehensive and updated review on two primary stromal choroiditis entities, Vogt-Koyanagi-Harada disease (VKH) and birdshot retinochoroiditis (BRC). Their appraisal has become much more precise thanks to new investigational methods, such as indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT), which give substantially improved imaging access to the choroid. In this review, we focus on the crucial changes brought by this progress in the understanding, diagnosis, and management of these disorders. Application of these methods makes it possible to reach an early diagnosis, therefore allowing early treatment, which has led to a profound improvement in outcomes when compared to previous management.

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Features of Optical Coherence Tomography for the Diagnosis of Vogt–koyanagi–harada Disease

Abstract: OCT-related morphological signs have a relatively high predictive value for the diagnosis of acute VKH.

Cited by 45 publications

References 35 publications

Bilateral serous retinal detachment associated with subretinal fibrin-like material in a case of pregnancy-induced hypertension

Bilateral serous retinal detachment associated with subretinal fibrin-like material in a case of pregnancy-induced hypertension

Bilateral posterior scleritis presenting as acute primary angle closure: A case report

Vogt-Koyanagi-Harada Disease and Birdshot Retinochoroidopathy, Similarities and Differences: A Glimpse into the Clinicopathology of Stromal Choroiditis, a Perspective and a Review

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