Features of free radical oxidation of lipids in cows with fat liver dystrophy

Abstract

The mechanisms of the pathogenesis of liver damages of various genesis include destabilization of hepatocyte membranes, depending on the initiation of lipid peroxidation. The article presents re-search to determine the characteristics of lipid peroxidation in cows with fatty liver dystrophy. It was found out that in highly productive Holstein cows with a diagnosis of fatty hepatosis, the pro-cesses of free radical lipid oxidation are activated with an increase in the concentration of all lipoperoxidation products (diene conjugates, ketodienes and malondialdehyde) in blood and milk. Moreover, in sick animals, the level of antioxidant defense indicators such as carotene, vitamin C and glutathione peroxidase decreases.

Research of the detoxification properties of the preparation phytoglinol on the heat stress model

“…The development of stress syndrome in laboratory animals was characterized by the accumulation of lipid peroxidation products in the bodyboth primary (diene conjugates -DC, ketodienes -KD) and secondary (malondialdehyde -MDA) and by a violation of the prooxidant-antioxidant balance, leading to damage of cell membranes and an increase in their permeability (table 4) [11].…”