Feasibility study of endoscopic x-ray luminescence computed tomography: Simulation demonstration and phantom application

Abstract

Even though endoscopic fluorescence diffuse optical tomography (eFDOT) exhibits significant potential, currently its application is limited due to the existence of strong autofluorescence and the imaging inaccuracy caused by a very short source-detector distance. Motivated by the emerging X-ray luminescence computed tomography (XLCT) technology, we presented an endoscopic XLCT (eXLCT) methodology. In the methodology, the aperture angle of the objective was incorporated into the forward model, providing a more accurate description of light propagation. Numerical simulation with a heterogeneous geometry and an imaging experiment with a physical phantom were illustrated to demonstrate the feasibility of the presented eXLCT methodology.

Hybrid radiosity-SP3 equation based bioluminescence tomography reconstruction for turbid medium with low- and non-scattering regions

“…The DiE is defined as the distance error between the reconstructed and actual sources, the IVTVR denotes the ratio of the intersected volume of reconstructed source with the actual one to the total reconstructed volume, and the QE is the density error between the reconstructed and the actual source. 17,18 In the simulations, a mouse model extracted from a digital mouse atlas 19 was employed, which was comprised of six main organs (shown in Fig. 2(a)) with the related optical properties listed in Table I.…”

Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging

“…The first demonstration of XLCT imaging was reported by Pratx et al using a selective excitation scanning scheme, much like first generation x-ray CT scanners [3,4] and then by many other groups [5][6][7]. Since then, due to many advantages of XLCT imaging, several research groups, including our own, have pursued the improvement of XLCT from different aspects [8][9][10][11][12].…”

Cone Beam X-Ray Luminescence Tomography Imaging Based on KA-FEM Method for Small Animals

“…The discovery that both X-ray and visible light can propagate through tissue and that the nanophosphors agents can trace specific molecular makes XLT a proper tool for in vivo biomedical imaging. Nowadays, XLT technology has also been extended from narrow beam X-ray [1] to cone beam X-ray excitation [2] and is even applied in endoscopic imaging [3]. Meanwhile, with advanced specific materials for X-ray excitation, it has also been applied in small animal in vivo imaging [4].…”

“…Badea et al invented a battleship sampling paradigm to mix sampling and reconstruction in narrow beam XLT system [8]. In addition, Chen et al designed a cone beam XLT imaging system [2] and Chen et al put forward a reconstruction method with single view data in cone beam XLT system [3]. Even though the imaging time in the reconstruction method with single view data is reported to be less than 30 s [3], reconstructed result with planar detectors and a single view is generally insufficient for accurate 3D reconstruction [9].…”

“…In addition, Chen et al designed a cone beam XLT imaging system [2] and Chen et al put forward a reconstruction method with single view data in cone beam XLT system [3]. Even though the imaging time in the reconstruction method with single view data is reported to be less than 30 s [3], reconstructed result with planar detectors and a single view is generally insufficient for accurate 3D reconstruction [9]. The inverse problem of reconstruction is an ill-posed problem and can be improved by taking images of the experiment subject from multiple views [10] and using multispectral data [11].…”