Cone Beam X-Ray Luminescence Tomography Imaging Based on KA-FEM Method for Small Animals

Abstract

Cone beam X-ray luminescence tomography can realize fast X-ray luminescence tomography imaging with relatively low scanning time compared with narrow beam X-ray luminescence tomography. However, cone beam X-ray luminescence tomography suffers from an ill-posed reconstruction problem. First, the feasibility of experiments with different penetration and multispectra in small animal has been tested using nanophosphor material. Then, the hybrid reconstruction algorithm with KA-FEM method has been applied in cone beam X-ray luminescence tomography for small animals to overcome the ill-posed reconstruction problem, whose advantage and property have been demonstrated in fluorescence tomography imaging. The in vivo mouse experiment proved the feasibility of the proposed method.

Review of in vivo optical molecular imaging and sensing from x-ray excitation

“…The use of a partial angle approach to imaging is almost required for this type of work and several groups illustrated how this could be achieved in phantoms [25][26][27][28][29] and in vivo. 30,31 The major limitation in this aspect of work has been the sensitivity to mainly nanoscintillators used. The interaction mechanisms explored have largely been via direct excitation of the particle by the x-ray beam, where the reliance upon the photoelectric effect necessitates the use of high atomic number, Z, materials, and largely crystalline structures to gain sufficient radioluminescence yield from the process (see Fig.…”

Review of Tissue Oxygenation Sensing During Radiotherapy Based Upon Cherenkov-Excited Luminescence Imaging

“…This approach was advanced to include modeling of the diffusive light transport, accounting for signal loss as a function of distance between the emission site and the light detection at the surface. The use of a partial angle technique to imaging is almost essential for this type of work and several groups illustrated how this could be achieved in phantoms [60][61][62][63][64] and in vivo [65,66]. The major limitation in this aspect of work has been the requirement to use nanoscintillators which are large particulates and so biologically and biochemically incompatible without some toxicity.…”