2008
DOI: 10.1007/s00417-008-0813-8
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Feasibility study of chitosan as intravitreous tamponade material

Abstract: Chitosan intravitreous tamponade has no significant effect on the histology of the eye, doesn't cause intraocular pressure to fluctuate, and slightly increases inflammatory factors (IL-6, IL-8, NO) in comparison to the normal levels, but with no significant difference from the effects caused by sodium hyaluronate, which indicated chitosan might not lead to a clinically significant inflammatory response. It suggests that chitosan could be used as intravitreous tamponade material.

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Cited by 24 publications
(12 citation statements)
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“…Chitosan exhibits well-known properties, such as biodegradability, nontoxicity, biocompatibility, mucoadhesiveness, and antibacterial activity (Tang et al, 2010). Due to these favorable properties, chitosan is an important material in ophthalmological research (Basaran & Yazan, 2012;Felt et al, 1999;Fuente et al, 2010;Yang, Wang, Gu, & Zhang, 2008).…”
Section: Introductionmentioning
confidence: 98%
“…Chitosan exhibits well-known properties, such as biodegradability, nontoxicity, biocompatibility, mucoadhesiveness, and antibacterial activity (Tang et al, 2010). Due to these favorable properties, chitosan is an important material in ophthalmological research (Basaran & Yazan, 2012;Felt et al, 1999;Fuente et al, 2010;Yang, Wang, Gu, & Zhang, 2008).…”
Section: Introductionmentioning
confidence: 98%
“…Chemically different compounds such as hyaluronic acid (Healon R ), perfluorinated organic liquids and various synthetic polymers have been tested in the laboratory (Denlinger et al 1980, 1980b, Koster et al 1986, 1986b A fairly recent idea is to explore substances used successfully in other surgical areas (Yang et al 2008). One potential compound is the acrylamide-derivative Bio-Alcamid ® (Polyalkylimide), a clear hydrogel used as subcutaneous filler in reconstructive plastic surgery (Lahiri et al 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Recent tamponade strategies therefore aim at hydrophilic, hydrogel-based systems (reviewed by Su et al 11 ). In addition to synthetic polymers, biopolymers such as hyaluronic acid, [12][13][14][15][16][17] collagen, 17,18 gellan, 16,19 chitosan, 20,21 and alginate 21 were investigated for the preparation of hydrophilic retinal tamponades. However, previous concepts were mainly limited by intransparency, deviating refractive indices, fast degradation, or insufficient biocompatibility, especially because of lack of substance purity or toxic cross-linking agents.…”
Section: Introductionmentioning
confidence: 99%