Feasibility of X-ray interstitial radiosurgery based on plasma focus device

Tartari, A.; Re, Andrea Da; Mezzetti, F.; Angeli, E.; Chiara, P. De

doi:10.1016/s0168-583x(03)01655-0

Cited by 29 publications

(16 citation statements)

References 5 publications

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“…The electron beam emitted from the plasma focus was already demonstrated for the application of printing 0.5 µm size feature by lithography technique [1]. More recently, Tartari et al proposed X-ray brachytherapy source based on the principle of interaction of a relativistic electron beam of plasma focus with high Z target [2]. Basically, the plasma focus is a transient plasmaproducing device that makes use of a self-generated magnetic field to pinch the plasma to a high dense and hot plasma column.…”

mentioning

confidence: 99%

Study on electron beam emission from a low energy plasma focus device

Neog

Mohanty

2007

Physics Letters A

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mentioning

confidence: 99%

Study on electron beam emission from a low energy plasma focus device

Neog

Mohanty

2007

Physics Letters A

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“…Therapeutic effect is reached due to a very high Linear Energy Transfer (LET) of the nuclear reaction products, which are generated at the interaction of thermal or epithermal neutrons with Boron atoms 10 Mean-free-paths (MFP) of lithium nuclei and alpha-particles within human tissues are equal to 6 and 9 μm respectively, what makes a release of their energy to be practically local in the vicinity of a zone of neutron's absorption.…”

Section: E) Thermal and Fast Neutrons And X-rays In Boron Neutron Capmentioning

confidence: 99%

“…Because electron beam (with electron's energy about 100 keV) generated in DPF can be transported along large distances (~ 1 meter) inside the anode's tube due to the back-current induced in the tube's wall it can be used for brachytherapy both by the ebeam itself and by hard X-rays generated by it on a proper target [10].…”

Section: F) Brachytherapymentioning

confidence: 99%

Current and Perspective Applications of Dense Plasma Focus Devices

Грибков¹

2008

AIP Conference Proceedings

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Abstract. Dense Plasma Focus (DPF) devices' applications, which are intended to support the main-stream large-scale nuclear fusion programs (NFP) from one side (both in fundamental problems of Dense Magnetized Plasma physics and in its engineering issues) as well as elaborated for an immediate use in a number of fields from the other one, are described. In the first direction such problems as self-generated magnetic fields, implosion stability of plasma shells having a high aspect ratio, etc. are important for the Inertial Confinement Fusion (ICF) programs (e.g. as NIF), whereas different problems of current disruption phenomenon, plasma turbulence, mechanisms of generation of fast particles and neutrons in magnetized plasmas are of great interest for the large devices of the Magnetic Plasma Confinement -MPC (e.g. as ITER). In a sphere of the engineering problems of NFP it is shown that in particular the radiation material sciences have DPF as a very efficient tool for radiation tests of prospect materials and for improvement of their characteristics. In the field of broad-band current applications some results obtained in the fields of radiation material sciences, radiobiology, nuclear medicine, express Neutron Activation Analysis (including a single-shot interrogation of hidden illegal objects), dynamic non-destructive quality control, X-Ray microlithography and micromachining, and micro-radiography are presented. As the examples of the potential future applications it is proposed to use DPF as a powerful high-flux neutron source to generate very powerful pulses of neutrons in the nanosecond (ns) range of its duration for innovative experiments in nuclear physics, for the goals of radiation treatment of malignant tumors, for neutron tests of materials of the first wall, blankets and NFP device's constructions (with fluences up to 1 dpa per a year term), and ns pulses of fast electrons, neutrons and hard X-Rays for brachytherapy.

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“…Among other effects, a strong collimated beam of electrons is produced along the symmetry axis of the device. [2,3] The electrons can be made to impinge on a target to produce an intense, low-energy X-ray beam. A possible application, consistent with the energy range of the X-rays, is the irradiation of tissue at shallow depth, as is required in Intra-Operative Radiation Therapy.…”

Section: Introductionmentioning

confidence: 99%

Analysis and characterization of the X‐ray beam produced by a PF device for radiotherapy applications

et al. 2015

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A plasma focus device, devoted to the study of a possible application to the radiotherapy treatment of malignant cells, has been recently put into operation. The low-energy (up to 200 keV) X-rays are produced by conversion of the electron beam generated by the device during the pinch phase. The X-ray spectrum has already been fully characterized, and an initial campaign of irradiation of specific cell cultures has been completed. At present, the links between the operational parameters of the actual device, the beam intensity, and the cell irradiation effects are being analyzed, trying to evaluate the advantage of the very high dose rate that can be delivered, of the order of several Gy in a few tens of nanoseconds. Preliminary results on radiobiological effectiveness are presented and discussed.

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Feasibility of X-ray interstitial radiosurgery based on plasma focus device

Cited by 29 publications

References 5 publications

Study on electron beam emission from a low energy plasma focus device

Study on electron beam emission from a low energy plasma focus device

Current and Perspective Applications of Dense Plasma Focus Devices

Analysis and characterization of the X‐ray beam produced by a PF device for radiotherapy applications

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