Feasibility of ultrasound-guided high intensity focused ultrasound ablating uterine fibroids with hyperintense on T2-weighted MR imaging

Zhao, Wenpeng; Chen, Jin-Yun; Zhang, Lian; Li, Quan; Qin, Juan; Song, Peng; Li, Kequan; Wang, Zhibiao; Chen, Wenzhi

doi:10.1016/j.ejrad.2012.08.020

Cited by 94 publications

(75 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it can produce a larger zone of ablation in a shorter amount of time. In contrast, the focal regions of HIFU are 3 mm × 8 mm and must follow the treatment principle from point to plane to volume, and there is energy attenuation during transmission of the ultrasonic wave and a cooling effect due to blood flow during treatment [19,20]. This leads to a tissue temperature produced by HIFU that is significantly lower than that of MWA, and the ablation efficiency is decreased.…”

Section: Discussionmentioning

confidence: 97%

A retrospective comparison of microwave ablation and high intensity focused ultrasound for treating symptomatic uterine fibroids

Zhao¹,

Han²,

Zhang³

et al. 2015

European Journal of Radiology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

A retrospective comparison of microwave ablation and high intensity focused ultrasound for treating symptomatic uterine fibroids

Zhao¹,

Han²,

Zhang³

et al. 2015

European Journal of Radiology

Self Cite

View full text Add to dashboard Cite

“…MRI is often used to evaluate the treatment efficacy of HIFU for uterine fibroids. Many studies have shown that enhanced MRI could offer the most accurate results of the size of uterine fibroids and the non-perfused volume (NPV) [12][13][14]. Recently, some studies have shown that the fractional ablation of uterine fibroid, which was defined as the percentage rate of the NPV comparing with overall fibroid volume, calculated by MRI after HIFU treatment, was the most important factor influencing the long-term clinical results of HIFU ablation [15,16].…”

Section: Discussionmentioning

confidence: 98%

Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids

Song

Chen

et al. 2015

Ultrasonics

Self Cite

View full text Add to dashboard Cite

“…Funaki et al (4) demonstrated that the nonperfused volume ratio in type I is higher than that in the other types, and most of the fibroids that showed significant volume reduction on follow-up were hypointense (type I). Zhao et al (12) further found that hyperintensity on T2-weighted images of a fibroid indicates the presence of angiogenesis, richness of aqueous tissue, and cell components with less fibrous tissue, whereas hypointensity or isointensity on T2-weighted images of a fibroid indicates that angiogenesis is less common and the fibrous content is richer than that of fibroids with hyperintensity on T2-weighted images. Mikami et al (13) reported that the uterine fibroids in the failed treatment group demonstrated heterogeneous and high SI on T2-weighted images relative to that of the myometrium, whereas the uterine fibroids in the successful treatment group demonstrated low SI relative to that of the myometrium.…”

Section: T2-weighted Imagingmentioning

confidence: 99%

Review of influential clinical factors in reducing the risk of unsuccessful MRI-guided HIFU treatment outcome of uterine fibroids

Duc

Keserci

2018

Diagn Interv Radiol

View full text Add to dashboard Cite

U terine fibroids, composed of smooth muscle cells and fibrous connective tissue derived from the myometrium, are common benign gynecological tumors that have a significant negative effect on the quality of life of a patient. Symptoms of uterine fibroids vary depending on their size and location, but the main symptoms are pelvic pain, menorrhagia or dysmenorrhea, increased frequency of urination, and reproductive dysfunction, including impaired fertility, pregnancy complications and loss (1, 2).The choice of treatment and its rate of success are dependent on the morphology and tissue characteristics of the uterine fibroids. Hysterectomy remains the definitive treatment for uterine fibroids, but this treatment option is unsuitable for women who wish to preserve their fertility. In the last decade, patient demands have spurred the development of a noninvasive therapeutic modality for symptomatic uterine fibroids called magnetic resonance imaging-guided high-intensity focused ultrasound (MRI-guided HIFU) (3-11).The principle of HIFU treatment of uterine fibroids is that focused ultrasonic energy causes coagulative necrosis of the target. Since its first clinical use for treating symptomatic uterine fibroids, the use of HIFU has increased worldwide because of its excellent therapeutic efficacy in relieving fibroid-related symptoms, its ability to preserve the uterus, and its high level of safety (3-7). However, as shown in previous studies (8-11), MRI-guided HIFU ablation therapy cannot be used in all patients with symptomatic fibroids because of the tissue characteristics of the uterine fibroids such as the T1 and T2 MRI signal intensity (SI), and fibroid type defined by general uterine position, fibroid size, and fibroid number. In addition, technical limitations, including the presence of scar tissue, excessive abdominal subcutaneous fat, the distance between the skin and the fibroids, the distance between the sacral bone surface and the fibroids, and the bowel in the path of sonication, play a role in whether MRI-guided HIFU therapy is appropriate.In this article, we present a literature review of the influential clinical factors that might reduce the risk of an unsuccessful MRI-guided HIFU treatment outcome of uterine fibroids. Tissue characteristics of uterine fibroids T2-weighted imagingT2 SI is the primary MRI classification parameter for determining patient suitability for MRI-guided HIFU. A patient is classified as type I when the SI of the uterine fibroid is lower than that of skeletal muscle, type II when the SI is lower than that of the myometrium but higher than that of skeletal muscle, or type III when the SI is higher than that of the myometrium (Fig. 1) (4). As shown by previous studies (4-13), uterine fibroids with different SIs on ABSTRACTMagnetic resonance imaging-guided high-intensity focused ultrasound (MRI-guided HIFU) is an effective noninvasive treatment option for symptomatic uterine fibroids. However, tissue characteristics of uterine fibroids and technical limitations can limit the patie...

show abstract

Feasibility of ultrasound-guided high intensity focused ultrasound ablating uterine fibroids with hyperintense on T2-weighted MR imaging

Cited by 94 publications

References 19 publications

A retrospective comparison of microwave ablation and high intensity focused ultrasound for treating symptomatic uterine fibroids

A retrospective comparison of microwave ablation and high intensity focused ultrasound for treating symptomatic uterine fibroids

Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids

Review of influential clinical factors in reducing the risk of unsuccessful MRI-guided HIFU treatment outcome of uterine fibroids

Contact Info

Product

Resources

About